-
公开(公告)号：US20240166753A1
公开(公告)日：2024-05-23
申请号：US18482629
申请日：2023-10-06
发明人： Gregory P. Chang , Ann F. Cheung , William Haney , Asya Grinberg
CPC分类号： C07K16/2851 , A61P35/00 , C07K16/2803 , C07K16/283 , C07K16/2878 , C07K16/2887 , C07K16/32 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/524 , C07K2317/569 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/94
摘要： Multi-specific binding proteins that bind a tumor associated antigen, the NKG2D receptor, and CD16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
公开(公告)号：US11884732B2
公开(公告)日：2024-01-30
申请号：US16486569
申请日：2018-02-20
CPC分类号： C07K16/2851 , A61P35/00 , C07K16/283 , C07K16/32 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/53 , C07K2317/565 , C07K2317/569 , C07K2317/732 , C07K2317/94
摘要： Multi-specific binding proteins that bind HER2, the NKG2D receptor, and CD 16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
3.发明公开公开(公告)号：US20230303702A1
公开(公告)日：2023-09-28
申请号：US18150040
申请日：2023-01-04
发明人： Gregory P. Chang , Ann F. Cheung , Asya Grinberg , Eva Gutierrez , William Haney , Bradley M. Lunde , Nicolai Wagtmann , Bianka Prinz
IPC分类号： C07K16/28 , A61P35/00 , A61K31/675 , A61K47/64 , C07K14/55 , A61K31/7084 , A61K31/337 , A61P35/02 , A61K39/395 , A61K47/69 , C07K16/32 , A61K39/00
CPC分类号： C07K16/2851 , A61K31/337 , A61K31/675 , A61K31/7084 , A61K39/3955 , A61K39/39558 , A61K47/643 , A61K47/6929 , A61P35/00 , A61P35/02 , C07K14/55 , C07K16/32 , C07K16/283 , C07K16/2803 , C07K16/2818 , C07K16/2878 , A61K2039/505 , C07K2317/31 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2317/524 , C07K2317/565 , C07K2317/569 , C07K2317/732 , C07K2317/734
摘要： Combination therapy of a cancer with a multi-specific binding protein that bind a tumor associated antigen, the NKG2D receptor, and CD16, in combination with a second anti-cancer agent are described. Also described are pharmaceutical compositions of the multi-specific binding protein, and therapeutic methods useful for the treatment of cancer in combination with a second anti-cancer agent.
-
公开(公告)号：US20220025037A1
公开(公告)日：2022-01-27
申请号：US17045015
申请日：2019-04-03
发明人： Hemanta Baruah , Ann F. Cheung , Daniel Fallon , Asya Grinberg , William Haney , Steven O'Neil
摘要： Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting DLL3 (Delta-like 3) on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.
-
公开(公告)号：US20210130496A1
公开(公告)日：2021-05-06
申请号：US16488395
申请日：2018-02-27
发明人： Gregory P. Chang , Ann F. Cheung , Eva Gutierrez , William Haney , Bradley M. Lunde , Bianka Prinz
摘要： Multi-specific binding proteins that bind the NKG2D receptor, CD 16, and a tumor-associated antigen selected from carbonic anhydrase 9 (CAIX), anoctamin-1 (ANO1), mesothelin, TROP2, CEA and claudin-18.2 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
公开(公告)号：US20200216544A1
公开(公告)日：2020-07-09
申请号：US16638559
申请日：2018-08-16
发明人： Gregory P. Chang , Ann F. Cheung , Jinyan Du , Asya Grinberg , William Haney , Dhruv Kam Sethi , Nicolai Wagtmann , Bradley M. Lunde , Bianka Prinz
摘要： Multi-specific binding proteins that bind NKG2D receptor, CD16, and a tumor-associated antigen selected from EGFR, HLA-E, CCR4, and PD-L1 are described, as well pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
公开(公告)号：US20200024353A1
公开(公告)日：2020-01-23
申请号：US16483788
申请日：2018-02-10
IPC分类号： C07K16/28 , C07K14/705 , C07K16/30
摘要： Multi-specific binding proteins that bind PSMA, the NKG2D receptor, and CD 16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
公开(公告)号：US20240228625A1
公开(公告)日：2024-07-11
申请号：US18541475
申请日：2023-12-15
CPC分类号： C07K16/2851 , A61P35/00 , C07K16/283 , C07K16/32 , C07K2317/31 , C07K2317/33 , C07K2317/524 , C07K2317/53 , C07K2317/565 , C07K2317/569 , C07K2317/732 , C07K2317/94
摘要： Multi-specific binding proteins that bind HER2, the NKG2D receptor, and CD16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
公开(公告)号：US20240018266A1
公开(公告)日：2024-01-18
申请号：US18304652
申请日：2023-04-21
CPC分类号： C07K16/40 , C07K16/28 , C07K16/32 , C07K16/2896 , C07K16/283 , C07K2319/00 , C07K2317/76 , C07K2317/31 , C07K2317/52 , C07K2317/565 , C07K2317/732 , A61P35/02
摘要： Multi-specific binding proteins that bind CD123, the NKG2D receptor, and CD16 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
公开(公告)号：US20230391877A1
公开(公告)日：2023-12-07
申请号：US18107292
申请日：2023-02-08
CPC分类号： C07K16/2851 , A61P35/00 , C07K16/18 , C07K16/28 , C07K16/283 , C07K16/30 , C07K16/40 , C07K16/46 , C07K2317/31 , C07K2317/524 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/94 , C07K2317/53
摘要： Multi-specific binding proteins that bind the NKG2D receptor, CD16, and a tumor-associated antigen selected from carbonic anhydrase 9 (CAIX), anoctamin-1 (ANO1), mesothelin, TROP2, CEA and claudin-18.2 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.
-
-
-
-
-
-
-
-
-
搜索结果
49 条记录 (耗时 0.021 秒)
