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1.发明授权Immobilized tumor necrosis factor-α muteins for enhancing immune response in mammals 有权固定化的肿瘤坏死因子-α突变蛋白，用于增强哺乳动物的免疫反应公开(公告)号：US08501918B2
公开(公告)日：2013-08-06
申请号：US12378078
申请日：2009-02-11
Applicant: Mark Douglas Howell
Inventor： Mark Douglas Howell
IPC: C07K14/525 , C07K17/02 , C07K17/12 , C07K17/14 , A61K35/14
CPC classification number: A61M1/3621 , A61K38/00 , A61M1/3615 , A61M1/38 , C07K14/525
Abstract: The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) such as TNFα muteins capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNFα mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor.
Abstract translation: 本发明提供了一种用于增强哺乳动物的免疫应答以促进消除慢性病理学的方法。 该方法包括从哺乳动物的循环中除去免疫系统抑制剂如可溶性TNF受体，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除通过使哺乳动物的生物流体与一种或多种结合配偶体（例如TNFα突变蛋白质）接触，从而与生物流体结合并从而消耗靶向的免疫系统抑制剂来实现。 在本发明中特别有用的是一种吸收性基质，其由与能够特异性结合靶向免疫系统抑制剂如可溶性TNF受体的结合配偶体（例如TNFα突变蛋白）共价连接的惰性生物相容底物组成。
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公开(公告)号：US07370904B2
公开(公告)日：2008-05-13
申请号：US11384290
申请日：2006-03-21
Applicant: Robert A. Wood, Jr. , Douglas Howell
Inventor： Robert A. Wood, Jr. , Douglas Howell
IPC: B60P7/04
CPC classification number: B60J7/085
Abstract: A cover assembly for a vehicle carried open top container wherein a cover is connected at one end to a vertically adjustable tower and an opposite end to a cross member connected to a pair of pivot arms that are mounted at their lower ends to be pivoted by at least one hydraulic actuator that is mounted to the vehicle intermediate opposite ends of the container and adjacent the bottom thereof. An effective length of each pivot arm may be adjusted and locked in adjusted position.
Abstract translation: 一种用于车辆的盖组件承载着敞开的顶部容器，其中一个盖子在一端连接到垂直可调节的塔架，并且与连接到一对枢轴臂的横向构件的相对端连接，所述横向构件安装在其下端以枢转 至少一个液压致动器，其安装到车辆的中间位于容器的相对端并且邻近其底部。 每个枢转臂的有效长度可以调节并锁定在调节位置。
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公开(公告)号：US06379708B1
公开(公告)日：2002-04-30
申请号：US09444144
申请日：1999-11-20
Applicant: Mark Douglas Howell , Cheryl Lynn Selinsky , Leland Charles Leber
Inventor： Mark Douglas Howell , Cheryl Lynn Selinsky , Leland Charles Leber
IPC: A61K3514
CPC classification number: C07K16/2878 , A61K35/14 , A61K2039/505 , A61M1/3486 , Y10T442/2525
Abstract: The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as an antibody, capable of specifically binding to the targeted immune system inhibitor.
Abstract translation: 本发明提供了一种用于增强哺乳动物的免疫应答以促进消除慢性病理学的方法。 该方法包括从哺乳动物的循环中除去免疫系统抑制剂，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除通过使哺乳动物的生物流体与能够与生物流体结合并从而消除靶向免疫系统抑制剂的一种或多种结合配偶体来实现。 在本发明中特别有用的是由与能够特异性结合靶向免疫系统抑制剂的结合配偶体（例如抗体）共价连接的惰性生物相容底物组成的吸收性基质。
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公开(公告)号：US20110201986A1
公开(公告)日：2011-08-18
申请号：US12915922
申请日：2010-10-29
Applicant: Mark Douglas Howell , Cheryl Lynn Selinsky , Leland Charles Leber
Inventor： Mark Douglas Howell , Cheryl Lynn Selinsky , Leland Charles Leber
IPC: A61M1/34
CPC classification number: C07K16/2878 , A61K35/14 , A61K2039/505 , A61M1/3486 , Y10T442/2525
Abstract: The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as an antibody, capable of specifically binding to the targeted immune system inhibitor.
Abstract translation: 本发明提供了一种用于增强哺乳动物的免疫应答以促进消除慢性病理学的方法。 该方法包括从哺乳动物的循环中除去免疫系统抑制剂，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除通过使哺乳动物的生物流体与能够与生物流体结合并从而消除靶向免疫系统抑制剂的一种或多种结合配偶体来实现。 在本发明中特别有用的是由与能够特异性结合靶向免疫系统抑制剂的结合配偶体（例如抗体）共价连接的惰性生物相容底物组成的吸收性基质。
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公开(公告)号：US20070222253A1
公开(公告)日：2007-09-27
申请号：US11384290
申请日：2006-03-21
Applicant: Robert Wood , Douglas Howell
Inventor： Robert Wood , Douglas Howell
IPC: B60J11/02
CPC classification number: B60J7/085
Abstract: A cover assembly for a vehicle carried open top container wherein a cover is connected at one end to a vertically adjustable tower and an opposite end to a cross member connected to a pair of pivot arms that are mounted at their lower ends to be pivoted by at least one hydraulic actuator that is mounted to the vehicle intermediate opposite ends of the container and adjacent the bottom thereof. An effective length of each pivot arm may be adjusted and locked in adjusted position.
Abstract translation: 一种用于车辆的盖组件承载着敞开的顶部容器，其中一个盖子在一端连接到垂直可调节的塔架，并且与连接到一对枢轴臂的横向构件的相对端连接，所述横向构件安装在其下端以枢转 至少一个液压致动器，其安装到车辆的中间位于容器的相对端并且邻近其底部。 每个枢转臂的有效长度可以调节并锁定在调节位置。
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Patent Agency Ranking
公开(公告)号：US20090227750A1
公开(公告)日：2009-09-10
申请号：US12378078
申请日：2009-02-11
Applicant: Mark Douglas Howell
Inventor： Mark Douglas Howell
IPC: C08H1/00 , C07K14/525
CPC classification number: A61M1/3621 , A61K38/00 , A61M1/3615 , A61M1/38 , C07K14/525
Abstract: The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) such as TNFα muteins capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNFα mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor.
Abstract translation: 本发明提供了一种用于增强哺乳动物的免疫应答以促进消除慢性病理学的方法。 该方法包括从哺乳动物的循环中除去免疫系统抑制剂如可溶性TNF受体，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除通过使哺乳动物的生物流体与一种或多种结合配偶体（例如TNFα突变蛋白质）接触，从而与生物流体结合并从而消耗靶向的免疫系统抑制剂来实现。 在本发明中特别有用的是一种吸收性基质，其由与能够特异性结合靶向免疫系统抑制剂如可溶性TNF受体的结合配偶体（例如TNFα突变蛋白）共价连接的惰性生物相容底物组成。
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公开(公告)号：US20050273150A1
公开(公告)日：2005-12-08
申请号：US11095208
申请日：2005-03-31
Applicant: Douglas Howell , William Gibbons , Matthew Carter , Victor Clark
Inventor： Douglas Howell , William Gibbons , Matthew Carter , Victor Clark
CPC classification number: A61F2/958 , A61F2/95 , A61F2/954 , A61F2/966 , A61F2/97 , A61F2002/041 , A61F2002/067 , A61F2250/0071
Abstract: A stent delivery system for positioning a first and second stent the first and second branch lumens of a bifurcation. The stent delivery system includes stent introducers and a sheath or catheter having a frangible wall. A method of delivering stents to anatomies such as bifurcated ducts or vessels.
Abstract translation: 一种用于将第一和第二支架定位成分叉的第一和第二分支腔的支架输送系统。 支架输送系统包括支架引入器和具有易碎壁的护套或导管。 将支架输送到诸如分叉管或血管的解剖结构的方法。
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公开(公告)号：US20080275376A1
公开(公告)日：2008-11-06
申请号：US12219100
申请日：2008-07-16
Applicant: Mark Douglas Howell , Cheryl Lynn Selinsky , Leland Charles Leber
Inventor： Mark Douglas Howell , Cheryl Lynn Selinsky , Leland Charles Leber
IPC: A61M37/00
CPC classification number: C07K16/2878 , A61K35/14 , A61K2039/505 , A61M1/3486 , Y10T442/2525
Abstract: The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as an antibody, capable of specifically binding to the targeted immune system inhibitor.
Abstract translation: 本发明提供了一种用于增强哺乳动物的免疫应答以促进消除慢性病理学的方法。 该方法包括从哺乳动物的循环中除去免疫系统抑制剂，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除通过使哺乳动物的生物流体与能够与生物流体结合并从而消除靶向免疫系统抑制剂的一种或多种结合配偶体来实现。 在本发明中特别有用的是由与能够特异性结合靶向免疫系统抑制剂的结合配偶体（例如抗体）共价连接的惰性生物相容底物组成的吸收性基质。
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公开(公告)号：US20080075690A1
公开(公告)日：2008-03-27
申请号：US11525519
申请日：2006-09-22
Applicant: Mark Douglas Howell
Inventor： Mark Douglas Howell
IPC: A61K38/19 , C07K14/525
CPC classification number: C07K14/525 , A61K38/00
Abstract: Provided is a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partners such as TNFα muteins capable of binding to and, thus, depleting the targeted immune system inhibitors from the biological fluids. Particularly useful is an adsorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNFα mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor.
Abstract translation: 提供了一种用于增强哺乳动物中的免疫应答以促进消除慢性病理学的方法。 该方法包括从哺乳动物的循环中除去免疫系统抑制剂如可溶性TNF受体，从而能够对病原体产生更强烈的免疫应答。 免疫系统抑制剂的去除通过使哺乳动物的生物流体与一种或多种结合配偶体例如TNFα突变蛋白质接触，从而与生物流体结合并从而消耗靶向的免疫系统抑制剂来实现。 特别有用的是由与能够特异性结合靶向免疫系统抑制剂例如可溶性TNF受体的结合配偶体诸如TNFα突变蛋白共价连接的惰性生物相容性底物组成的吸附剂基质。
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公开(公告)号：US20050084831A1
公开(公告)日：2005-04-21
申请号：US10687136
申请日：2003-10-17
Applicant: Robert Ison , Christopher Conlon , Douglas Howell , David Allen , Mark Reeve-Fowkes , Laurence Norman , Stephen Taylor
Inventor： Robert Ison , Christopher Conlon , Douglas Howell , David Allen , Mark Reeve-Fowkes , Laurence Norman , Stephen Taylor
Abstract: A training system uses a mechanical mock-up with electrically conductive probe points connected to electronically readable memories, and a simulated diagnostic tool to interface with a system or machine simulation for the purpose of operation, maintenance or procedure training. When a probe of a simulated diagnostic tool comes into contact with a probe point of the mechanical mock-up, the electronically readable memory supplies a unique identifier code that is communicated by the simulated diagnostic tool to the simulation to indicate the contact of the probe with the corresponding probe point. Complex wiring connections between the mechanical mock-up and a computer that runs the simulation are eliminated and construction of the training system is significantly simplified.
Abstract translation: 训练系统使用机械模型，连接到电子可读存储器的导电探针点，以及用于操作，维护或程序训练目的与系统或机器模拟接口的模拟诊断工具。 当模拟诊断工具的探针与机械模型的探针点接触时，电子可读存储器提供由仿真诊断工具传达到仿真的唯一标识符代码，以指示探针与 相应的探针点。 机械模型与运行模拟的计算机之间的复杂接线连接被消除，并且训练系统的构建被大大简化。
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