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    PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN
    8.
    发明申请
    PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN 审中-公开
    生产RIFAXIMIN多形态的方法

    公开(公告)号：US20120214989A1

    公开(公告)日：2012-08-23

    申请号：US13463714

    申请日：2012-05-03

    申请人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    发明人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    IPC分类号： C07D498/22

    CPC分类号： C07D498/22

    摘要： Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.

    摘要翻译： 结晶多形态的利福昔明（INN）抗生素名为利福昔明α和利福昔明，并且结晶形式名为利福昔明γ，可用于生产含有利福昔明用于口服和局部使用的药物制剂，并通过结晶进行 将生的利福昔明热溶解在乙醇中，并通过在确定的温度下加入水并在一定的时间内引起产物的结晶，然后在受控条件下进行干燥，直到达到沉淀的含水量 最终产品是本发明的目的。

    Polymorphic forms α, β and γ of rifaximin
    9.
    发明授权
    Polymorphic forms α, β and γ of rifaximin 有权
    多形态α，＆bgr; 和利福昔明的γ

    公开(公告)号：US08158781B2

    公开(公告)日：2012-04-17

    申请号：US13041332

    申请日：2011-03-04

    申请人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    发明人： Giuseppe Claudio Viscomi ,  Manuela Campana ,  Dario Braga ,  Donatella Confortini ,  Vincenzo Cannata ,  Paolo Righi ,  Goffredo Rosini

    IPC分类号： C07D498/22

    CPC分类号： C07D498/22 ,  C07B2200/13 ,  C07D491/22

    摘要： Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.

    摘要翻译： 结晶多形态的利福昔明（INN）抗生素名为利福昔明α和利福昔明，并且结晶形式名为利福昔明γ，可用于生产含有利福昔明用于口服和局部使用的药物制剂，并通过结晶进行 将生的利福昔明热溶解在乙醇中，并通过在确定的温度下加入水并在一定的时间内引起产物的结晶，然后在受控条件下进行干燥，直到达到沉淀的含水量 最终产品是本发明的目的。