公开(公告)号：US07585881B2

公开(公告)日：2009-09-08

申请号：US11053752

申请日：2005-02-09

Applicant: Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tau Xin ,  Jalaj Arora

Inventor： Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tau Xin ,  Jalaj Arora

IPC: A61K31/4439 ,  C07D401/14 ,  C07D413/04

CPC classification number: C07D487/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

Abstract translation: 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。

公开(公告)号：US20080045571A1

公开(公告)日：2008-02-21

申请号：US11840953

申请日：2007-08-18

Applicant: Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

Inventor： Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

IPC: A61K31/4439 ,  A61K31/4196 ,  A61K31/4245 ,  A61P19/06 ,  A61P25/18 ,  A61P25/30 ,  A61P29/00 ,  A61P9/00 ,  C07D413/14 ,  C12N5/00 ,  C07D271/06 ,  A61P35/00 ,  A61P27/02 ,  A61P25/28 ,  A61P25/08 ,  A61P19/02 ,  A61K31/443

CPC classification number: C07D487/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

Abstract translation: 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。

公开(公告)号：US20070179188A1

公开(公告)日：2007-08-02

申请号：US10588702

申请日：2005-02-15

Applicant: Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald Mcleod ,  Alexander Minidis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

Inventor： Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald Mcleod ,  Alexander Minidis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

IPC: A61K31/4439 ,  A61K31/4245 ,  C07D413/14 ,  C07D413/02

CPC classification number: C07D487/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

Abstract translation: 本发明涉及新的式（I）化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。

公开(公告)号：US20060122397A1

公开(公告)日：2006-06-08

申请号：US11274611

申请日：2005-11-14

Applicant: Jalaj Arora ,  Louise Edwards ,  Methvin Isaac ,  Donald McLeod ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Helena Gyback ,  Martin Johansson ,  Annika Kers ,  John Malmberg ,  Alexander Minidis ,  Karin Oscarsson ,  Mangus Waldman ,  Ulrika Yngve ,  Christoffer Osterwall

Inventor： Jalaj Arora ,  Louise Edwards ,  Methvin Isaac ,  Donald McLeod ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Helena Gyback ,  Martin Johansson ,  Annika Kers ,  John Malmberg ,  Alexander Minidis ,  Karin Oscarsson ,  Mangus Waldman ,  Ulrika Yngve ,  Christoffer Osterwall

IPC: A61K31/4439 ,  A61K31/4245 ,  C07D417/14 ,  C07D413/14 ,  C07D409/14

CPC classification number: C07D413/14 ,  C07D413/12 ,  C07D417/14

Abstract: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

Abstract translation: 本发明涉及新的式I化合物，其制备方法和其中制备的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。

公开(公告)号：US5616638A

公开(公告)日：1997-04-01

申请号：US406605

申请日：1995-03-20

Applicant: Michael Hallden-Abberton ,  Donald McLeod, Jr. ,  James S. Ritscher ,  Scot M. Turner

Inventor： Michael Hallden-Abberton ,  Donald McLeod, Jr. ,  James S. Ritscher ,  Scot M. Turner

IPC: B29C47/02 ,  B29C47/06 ,  B29C47/26 ,  B29K27/12 ,  B29K105/24 ,  B29L9/00 ,  B29L23/00 ,  F21V8/00 ,  G02B6/138 ,  B29D11/00

CPC classification number: B29C47/0023 ,  B29C47/065 ,  B29C47/26 ,  B29K2027/12 ,  B29K2033/04 ,  B29K2083/00

Abstract: Flexible composites, such as those useful as light pipes, may be effectively cured by reactions upon copolymerized alkoxysilane functionality. Improvements in the optical properties of the uncured and cured systems are found when the alkoxysilane monomer is stabilized during preparation, storage, and copolymerization with low levels of non-aromatic stable free radicals or stable free-radical precursors, such as nitroxides.

Abstract translation: 可以通过共聚的烷氧基硅烷官能团上的反应来有效地固化柔性复合材料，例如用作轻质管的那些。 当烷氧基硅烷单体在制备，储存和与低水平的非芳族稳定自由基或稳定的自由基前体如硝基氧的共聚过程中稳定时，发现未固化和固化体系的光学性质的改善。

公开(公告)号：US4860584A

公开(公告)日：1989-08-29

申请号：US213239

申请日：1988-06-29

Applicant: William C. Mercer ,  Peter K. Coughlin ,  Donald McLeod, Jr. ,  Edith M. Flanigen

Inventor： William C. Mercer ,  Peter K. Coughlin ,  Donald McLeod, Jr. ,  Edith M. Flanigen

IPC: G01N27/12 ,  G01N27/22

CPC classification number: G01N27/225 ,  G01N27/121

Abstract: A moisture sensing element is disclosed which comprises an electrically continuous article comprising a multi-compositional, multi-phase composite composition comprising as phases thereof (i) an electrically conducting or semiconducting substrate, (ii) an inorganic oxide composition layer in proximity to at least a portion of the surface of the electrically conducting or semiconducting substrate and (iii) an inorganic crystalline molecular sleeve composition layer upon at least a portion of the surface of the inorganic oxide composition layer, wherein the different phases of the composite composition are substantially contiguous and exhibit at least one of a distinct compositional heterogeneity and a distinct structural heterogeneity of one phase to the other; and at least one electrode affixed to the article in current carrying relationship so that the current carried by the electrode passes through at least a portion of the inorganic crystalline molecular sieve composition layer.

Abstract translation: 公开了一种湿度感测元件，其包括电连续制品，其包含多组分多相复合材料组合物，其包含其相位（i）导电或半导体衬底，（ii）至少接近于无机氧化物组合物层 所述导电或半导体衬底的表面的一部分和（iii）无机氧化物组合物层的表面的至少一部分上的无机结晶分子套管组合物层，其中所述复合组合物的不同相基本上是连续的， 表现出一个阶段与另一个阶段的不同组成异质性和不同结构异质性中的至少一个; 以及至少一个电极以电流携带关系固定在制品上，使得由电极承载的电流通过至少一部分无机结晶分子筛组合物层。

公开(公告)号：US20080312246A1

公开(公告)日：2008-12-18

申请号：US11997444

申请日：2006-08-04

Applicant: Louise Edwards ,  Abdelmalik Slassi ,  Methvin Isaac ,  Donald Mcleod ,  Tao Xin

Inventor： Louise Edwards ,  Abdelmalik Slassi ,  Methvin Isaac ,  Donald Mcleod ,  Tao Xin

IPC: A61K31/496 ,  A61P25/00 ,  A61P1/00 ,  C07D413/14 ,  A61K31/497

CPC classification number: C07D413/12 ,  C07D261/08 ,  C07D401/12 ,  C07D403/12

Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐或溶剂合物：其中Ar1，Ar2，Hy，L，R1，m和n如说明书中所定义。 本发明还包括药物组合物及其用途，制备该化合物的方法，以及用于治疗mGluR5介导的病症的方法。

公开(公告)号：US20080015234A1

公开(公告)日：2008-01-17

申请号：US11840952

申请日：2007-08-18

Applicant: Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

Inventor： Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

IPC: A61K31/4439 ,  A61K31/4196 ,  A61K31/4245 ,  A61P19/06 ,  A61P25/18 ,  A61P25/30 ,  A61P29/00 ,  A61P9/00 ,  C07D413/14 ,  C12N5/00 ,  C07D271/06 ,  A61P35/00 ,  A61P27/02 ,  A61P25/28 ,  A61P25/08 ,  A61P19/02 ,  A61K31/443

CPC classification number: C07D487/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

公开(公告)号：US20070255061A1

公开(公告)日：2007-11-01

申请号：US10582051

申请日：2004-12-13

Applicant: David Wensbo ,  Louise Edwards ,  Methvin Isaac ,  Donald McLeod ,  Abdelmalik Slassi ,  Tao Xin ,  Thomas Stormann

Inventor： David Wensbo ,  Louise Edwards ,  Methvin Isaac ,  Donald McLeod ,  Abdelmalik Slassi ,  Tao Xin ,  Thomas Stormann

IPC: A61K31/4439 ,  A61K31/41 ,  A61P1/00 ,  A61P25/00 ,  A61P25/18 ,  C07D257/04 ,  C07D401/04 ,  C12N5/06 ,  C12N5/08

CPC classification number: C07D213/84 ,  C07D401/04

Abstract: The present invention relates to new compounds of formula I, wherein Z, Q, X1, X2, R1 and R2, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

Abstract translation: 本发明涉及新的式I化合物，其中Z，Q，X 1，X 2，R 1和R 2如式I中所定义，或其盐，溶剂合物或溶剂化盐，其制备方法，含有所述 化合物和所述化合物在治疗中的用途。

公开(公告)号：US20050272779A1

公开(公告)日：2005-12-08

申请号：US11053752

申请日：2005-02-09

Applicant: Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

Inventor： Louise Edwards ,  Methvin Isaac ,  Martin Johansson ,  Annika Kers ,  Johan Malmberg ,  Donald McLeod ,  Alexander Mindis ,  Karin Staaf ,  Abdelmalik Slassi ,  Tomislav Stefanac ,  Thomas Stormann ,  David Wensbo ,  Tao Xin ,  Jalaj Arora

IPC: A61K31/4245 ,  A61K31/4439 ,  C07D413/14

CPC classification number: C07D487/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.

Abstract translation: 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。