公开(公告)号：US20140213647A1

公开(公告)日：2014-07-31

申请号：US14118347

申请日：2012-05-16

申请人： Won suk Sun ,  Hyo Jin Jeon ,  Dongsun Min ,  Woongsik Kim ,  Taeksu Kim ,  Do-Seung Kum ,  Keun-Ho Ryu ,  Hae-In Rhee ,  Yang Hae Park ,  Hyun-Joo Son ,  Eun-ju Park ,  Bong-yong Lee ,  Hojin Namgung ,  Minseok Park ,  Minseok Kang

发明人： Won suk Sun ,  Hyo Jin Jeon ,  Dongsun Min ,  Woongsik Kim ,  Taeksu Kim ,  Do-Seung Kum ,  Keun-Ho Ryu ,  Hae-In Rhee ,  Yang Hae Park ,  Hyun-Joo Son ,  Eun-ju Park ,  Bong-yong Lee ,  Hojin Namgung ,  Minseok Park ,  Minseok Kang

IPC分类号： C07C69/145

CPC分类号： C07C69/145 ,  A61K31/047 ,  A61K31/08 ,  A61K31/085 ,  A61K31/22

摘要： The present invention provides a compound of formula (I) or a prodrug thereof useful for treating or preventing irritable bowel syndrome, and a composition comprising the compound as an active ingredient. Also, the present invention provides a method for treating or preventing irritable bowel syndrome, which comprises administrating a therapeutically or prophylactically effective amount of the compound or the composition to a subject in need of treating or preventing irritable bowel syndrome.

摘要翻译： 本发明提供了可用于治疗或预防肠易激综合征的式（I）化合物或其前药，以及包含该化合物作为活性成分的组合物。 此外，本发明提供了治疗或预防肠易激综合征的方法，其包括向需要治疗或预防肠易激综合征的受试者施用治疗或预防有效量的化合物或组合物。

公开(公告)号：US08652537B2

公开(公告)日：2014-02-18

申请号：US13400784

申请日：2012-02-21

申请人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

发明人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

IPC分类号： A61K36/00

CPC分类号： A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

摘要翻译： 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

公开(公告)号：US20120148693A1

公开(公告)日：2012-06-14

申请号：US13400784

申请日：2012-02-21

申请人： Chang-Kyun HAN ,  Wie-Jong KWAK ,  Ki Won JOUNG ,  Hun Seung YOO ,  Do Seung KUM ,  Yong-Baik CHO ,  Keun Ho RYU ,  Hae In RHEE ,  Taek Su KIM ,  In Ho JUNG ,  So Yoon LEE ,  Jung Bum YI ,  Joo Hyon KIM ,  Key An UM

发明人： Chang-Kyun HAN ,  Wie-Jong KWAK ,  Ki Won JOUNG ,  Hun Seung YOO ,  Do Seung KUM ,  Yong-Baik CHO ,  Keun Ho RYU ,  Hae In RHEE ,  Taek Su KIM ,  In Ho JUNG ,  So Yoon LEE ,  Jung Bum YI ,  Joo Hyon KIM ,  Key An UM

IPC分类号： A61K36/716 ,  A61P19/02 ,  A61P19/04

CPC分类号： A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

摘要翻译： 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。

公开(公告)号：US20120128807A1

公开(公告)日：2012-05-24

申请号：US13321776

申请日：2010-05-20

申请人： Won Suck Sun ,  Taek-Su Kim ,  Woong Sik Kim ,  Do-Seung Kum ,  Keun-Ho Ryu ,  Hae-In Rhee ,  Hyo Jin Jeon ,  Dong Sun Min ,  Yang Hae Park ,  Hyun-Joo Son ,  Eun-Ju Park ,  Bong-Yong Lee ,  Hojin Namgung ,  Minseok Park ,  Euichaul Oh

发明人： Won Suck Sun ,  Taek-Su Kim ,  Woong Sik Kim ,  Do-Seung Kum ,  Keun-Ho Ryu ,  Hae-In Rhee ,  Hyo Jin Jeon ,  Dong Sun Min ,  Yang Hae Park ,  Hyun-Joo Son ,  Eun-Ju Park ,  Bong-Yong Lee ,  Hojin Namgung ,  Minseok Park ,  Euichaul Oh

IPC分类号： A61K36/284 ,  A61P1/00

CPC分类号： A61K36/284 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/3204 ,  A23V2250/21

摘要： The present invention relates to a composition or a method for treating or preventing irritable bowel syndrome. The present invention uses Atractylodes japonica rhizome extract, preferably the ethanol water solution extract of Atractylodes japonica rhizome, more preferably the 35-65 v/v % ethanol water solution extract of Atractylodes japonica rhizome for treating or preventing irritable bowel syndrome. Atractylodes japonica rhizome extract shows a surprising effect in suppressing visceral hypersensitivity or improving defecation abnormality caused by stress or bowel irritability.

摘要翻译： 本发明涉及治疗或预防肠易激综合征的组合物或方法。 本发明使用白术根茎提取物，优选白术的乙醇水溶液提取物，更优选用于治疗或预防肠易激综合征的白术的35-65v / v％乙醇水溶液提取物。 白术提取物在抑制内脏超敏反应或改善由应激或肠易激惹引起的排便异常方面表现出惊人的效果。

公开(公告)号：US07442714B2

公开(公告)日：2008-10-28

申请号：US10583438

申请日：2004-12-15

申请人： Jae-Sun Kim ,  Jin Young Choi ,  Je Ho Ryu ,  Nam Kyu Lee ,  Jeong-soo Jang ,  Woo Jae Jang ,  Key An Um ,  Do Seung Kum

发明人： Jae-Sun Kim ,  Jin Young Choi ,  Je Ho Ryu ,  Nam Kyu Lee ,  Jeong-soo Jang ,  Woo Jae Jang ,  Key An Um ,  Do Seung Kum

IPC分类号： A61K31/44 ,  C07D213/80

CPC分类号： C07D211/90

摘要： The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.

摘要翻译： 本发明涉及一种氨氯地平龙胆酸的酸性盐及其制备方法。 更具体地说，本发明涉及通过使氨氯地平和龙胆酸反应制备的下式1的氨氯地平结晶酸盐，其可用于治疗心血管疾病，并且具有毒性低，稳定性优异的药物 血液中的功效和持久的浓度。