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1.发明授权Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition 有权用于控制组织中的纤维化和其它病理沉积物的方法，包括施用GHRP-6组合物公开(公告)号：US08722626B2
公开(公告)日：2014-05-13
申请号：US13150526
申请日：2011-06-01
申请人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
发明人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.
摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。
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2.发明授权公开(公告)号：US08367620B2
公开(公告)日：2013-02-05
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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3.发明授权Treatment of multiple sclerosis by administration of interferon alpha and C-phycocyanin 失效通过施用干扰素α和C-藻蓝蛋白治疗多发性硬化症公开(公告)号：US08110182B2
公开(公告)日：2012-02-07
申请号：US12091776
申请日：2006-10-30
申请人： Giselle Penton Rol , Majel Cervantes Llanos , Eduardo Penton Arias , Diana Garcia del Barco Herrera , Carmen Maria Valenzuela Silva , Pedro Antonio Lopez Saura , Gerardo Enrique Guillen Nieto
发明人： Giselle Penton Rol , Majel Cervantes Llanos , Eduardo Penton Arias , Diana Garcia del Barco Herrera , Carmen Maria Valenzuela Silva , Pedro Antonio Lopez Saura , Gerardo Enrique Guillen Nieto
CPC分类号： A61K31/40 , A61K38/212 , A61K2300/00
摘要： The present invention consists of the combination of Interferon alpha and C-Phycocyanin (IFN-α/C-Phyco) for obtaining a pharmaceutical preparation for autoimmune disease, allergy and cancer treatments. The anti-inflammatory, immunomodulator, antioxidant, anti-viral, anti-proliferative and anti-tumoral effects, associated to the regulatory T cell inducer effect demonstrated in this invention is the rationale for the use of the IFN-α/C-Phyco combination in these diseases.
摘要翻译： 本发明由干扰素α和C-藻蓝蛋白（IFN-α/ C-Phyco）的组合组成，用于获得用于自身免疫疾病，过敏和癌症治疗的药物制剂。 与本发明中证明的调节性T细胞诱导物效应相关的抗炎，免疫调节剂，抗氧化剂，抗病毒，抗增殖和抗肿瘤作用是使用IFN-α/ C-Phyco组合的理由 在这些疾病中。
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4.发明申请Combination of EGF/GHRP-6 for Neurogeneration of Central Nervous System Following Autoimmune Damage 审中-公开EGF / GHRP-6用于自身免疫损伤后中枢神经系统神经生成的组合公开(公告)号：US20100093616A1
公开(公告)日：2010-04-15
申请号：US11885330
申请日：2006-02-24
申请人： Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , Jorge Amador Berlanga Acosta , Freya de los Milagros Freyre Almeida , Danay Cibrian Vera , Eduardo Pentón Arias
发明人： Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , Jorge Amador Berlanga Acosta , Freya de los Milagros Freyre Almeida , Danay Cibrian Vera , Eduardo Pentón Arias
IPC分类号： A61K38/18
CPC分类号： A61K38/08 , A61K38/1808 , A61K38/25 , A61K2300/00
摘要： The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.
摘要翻译： 本发明旨在刺激由于自身免疫损伤引起的中枢神经系统的神经再生。 特别地，包含治疗有效浓度的表皮生长因子和生长激素释放肽-6的药物组合被施用于患有多发性硬化症和视神经脊髓炎症状的受试者，并且校正由中枢神经中的自身反应性细胞引起的脱髓鞘 系统。
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5.发明授权Pharmaceutical combination for the treatment of tissue damage owing to an arterial irrigation defect 有权用于治疗由于动脉灌注缺损引起的组织损伤的药物组合公开(公告)号：US07361638B2
公开(公告)日：2008-04-22
申请号：US10220750
申请日：2001-12-17
申请人： Jorge Berlanga Acosta , Gerardo Enrique Guillen Nieto , Diana Garcia Del Barco Herrera , Julio Raul Fernandez Masso , Mario Pablo Estrada Garcia , Isabel Guillen Perez , Jose Suarez Alba , Rebeca Martinez Rodriguez
发明人： Jorge Berlanga Acosta , Gerardo Enrique Guillen Nieto , Diana Garcia Del Barco Herrera , Julio Raul Fernandez Masso , Mario Pablo Estrada Garcia , Isabel Guillen Perez , Jose Suarez Alba , Rebeca Martinez Rodriguez
IPC分类号： A61K38/08 , A61K38/18 , C07K14/485 , C07K14/495
CPC分类号： A61K38/1841 , A61K38/08 , A61K38/1808 , A61K38/25 , A61K38/27 , A61K2300/00
摘要： This invention relates to a medicine for humans, and particularly to a pharmaceutical combination comprising Epidermal Growth Factor (EGF) and Growth Hormone secretagogue hexapeptide (GHRP) for use in preventing tissue damage due to blood flow suppression by enhancing tissue repair following ischemic damage. The aforementioned combination may be applied as a single pharmaceutical composition. Alternatively, an individual may also receive both EGF and GHRP in a separate manner but within a single therapeutic regime to enhance cellular survival when organs are subjected to blood flow deprivation for a critical period of time. This combination attenuates reactive oxygen species (ROS) formation and its associated cytotoxicity. It is also useful in promoting cellular survival when tissue or organs are exposed to prolonged ischemic periods. The combination is useful as a prophylactic agent in those subjects prone to multiple organ failure (MOF) such as burn victims, multiple trauma patients, hypoxic neonates, acute respiratory distress syndrome patients, and necrotizing enterocolitis patients.
摘要翻译： 本发明涉及用于人的药物，特别涉及包含表皮生长因子（EGF）和生长激素促分泌素六肽（GHRP）的药物组合，用于通过增强缺血性损伤后的组织修复来预防由于血流抑制引起的组织损伤。 上述组合可以作为单一药物组合物使用。 或者，个体也可以以单独的方式接受EGF和GHRP，但是在单一治疗方案内，以便当器官在关键时间段内遭受血流剥夺时增强细胞存活。 这种组合减弱活性氧（ROS）形成及其相关的细胞毒性。 当组织或器官暴露于长时间缺血期时，它也可促进细胞存活。 该组合在易受多器官功能衰竭（MOF）的受试者，如烧伤受试者，多发性创伤患者，缺氧新生儿，急性呼吸窘迫综合征患者和坏死性小肠结肠炎患者中的预防剂是有用的。
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6.发明申请Pharmaceutical Composition Containing GHRP-6 To Prevent And Eliminate Fibrosis And Other Pathological Deposits In Tissues 有权含有GHRP-6的药物组合物用于预防和消除组织中的纤维化和其他病理沉积公开(公告)号：US20110230415A1
公开(公告)日：2011-09-22
申请号：US13150526
申请日：2011-06-01
申请人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
发明人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillén Nieto , José Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.
摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。
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7.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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8.发明申请Interferon AlPha And C-Phycocyanin For The Treatment Of Autoimmune Diseases, Allergy And Cancer 失效干扰素AlPha和C-藻蓝蛋白治疗自身免疫性疾病，过敏和癌症公开(公告)号：US20090280087A1
公开(公告)日：2009-11-12
申请号：US12091776
申请日：2006-10-30
申请人： Giselle Penton Rol , Majel Cervantes Llanos , Eduardo Penton Arias , Diana Garcia del Barco Herrera , Carmen Maria Valenzuela Silva , Pedro Antonio Lopez Saura , Gerardo Enrique Guillen Nieto
发明人： Giselle Penton Rol , Majel Cervantes Llanos , Eduardo Penton Arias , Diana Garcia del Barco Herrera , Carmen Maria Valenzuela Silva , Pedro Antonio Lopez Saura , Gerardo Enrique Guillen Nieto
CPC分类号： A61K31/40 , A61K38/212 , A61K2300/00
摘要： The present invention consists of the combination of Interferon alpha and C-Phycocyanin (IFN-α/C-Phyco) for obtaining a pharmaceutical preparation for autoimmune disease, allergy and cancer treatments. The anti-inflammatory, immunomodulator, antioxidant, anti-viral, anti-proliferative and anti-tumoral effects, associated to the regulatory T cell inducer effect demonstrated in this invention is the rationale for the use of the IFN-α/C-Phyco combination in these diseases.
摘要翻译： 本发明由干扰素α和C-藻蓝蛋白（IFN-α/ C-Phyco）的组合组成，用于获得用于自身免疫疾病，过敏和癌症治疗的药物制剂。 与本发明中证明的调节性T细胞诱导物效应相关的抗炎，免疫调节剂，抗氧化剂，抗病毒，抗增殖和抗肿瘤作用是使用IFN-α/ C-Phyco组合的理由 在这些疾病中。
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9.发明申请PHARMACEUTICAL COMPOSITION CONTAINING GHRP-6 TO PREVENT AND ELIMINATE FIBROSIS AND OTHER PATHOLOGICAL DEPOSITS IN TISSUES 审中-公开包含GHRP-6的药物组合物可预防和消除组织中的纤维化和其他病理沉积物公开(公告)号：US20090221512A1
公开(公告)日：2009-09-03
申请号：US12281018
申请日：2007-02-23
申请人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillen Nieto , Jose Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
发明人： Jorge Berlanga Acosta , Danay Cibrian Vera , Diana Garcia Del Barco Herrera , Gerardo Enrique Guillen Nieto , Jose Suarez Alba , Ernesto Lopez Mola , Manuel Selman-Housein Sosa , Mariela Vazquez Castillo
IPC分类号： A61K38/08
摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.
摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。
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10.发明授权Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy 有权使用表皮生长因子进行糖尿病神经病变外周神经的形态功能恢复公开(公告)号：US08642552B2
公开(公告)日：2014-02-04
申请号：US12443837
申请日：2007-10-01
申请人： Jose Ignacio Fernandez Montequin , Luis Saturnino Herrera Martinez , Jorge Amador Berlanga Acosta , Diana Garcia Del Barco Herrera , Danay Cibrian Vera , Gerardo Enrique Guillen Nieto , Raimundo Ubieta Gomez , Sonia Gonzalez Blanco , Vivian Maria Saez Martinez
发明人： Jose Ignacio Fernandez Montequin , Luis Saturnino Herrera Martinez , Jorge Amador Berlanga Acosta , Diana Garcia Del Barco Herrera , Danay Cibrian Vera , Gerardo Enrique Guillen Nieto , Raimundo Ubieta Gomez , Sonia Gonzalez Blanco , Vivian Maria Saez Martinez
IPC分类号： A61P25/02 , A61K38/18 , C07K14/485
CPC分类号： A61K38/1808 , A61K9/16 , C07K14/485 , Y10S930/12
摘要： The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
摘要翻译： 本发明涉及人类药物和表皮生长因子（EGF）用于制备药物组合物的用途，所述药物组合物通过渗透到神经节和/或树干的周围而在疼痛的感觉运动神经病变中用于外周神经的形态功能恢复 以及缺血性神经炎的表现。 本发明还包括含有EGF的组合物，其可以与麻醉剂或止痛剂一起配制或包封在微球体中，以及其用于在疼痛敏感性运动型糖尿病性神经病变中的周围神经的形态功能恢复和缺血性神经炎的表现的用途。
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