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1.发明授权公开(公告)号：US08852601B2
公开(公告)日：2014-10-07
申请号：US10501697
申请日：2003-01-22
申请人： Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Amilcar Arenal Cruz , Rafael Marcos Pimentel Pérez , Antonio Morales Rojas , Eulogio Pimentel Vázquez , Alexander Espinosa Vázquez , Carmen Aday Garcia Molina , Edenaida Cabrera González , Mirta Vinjoy Campa , Sergio Toledo Pérez , Olimpia Carrillo Famés , Claudina Zaldivar Muñoz
发明人： Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Amilcar Arenal Cruz , Rafael Marcos Pimentel Pérez , Antonio Morales Rojas , Eulogio Pimentel Vázquez , Alexander Espinosa Vázquez , Carmen Aday Garcia Molina , Edenaida Cabrera González , Mirta Vinjoy Campa , Sergio Toledo Pérez , Olimpia Carrillo Famés , Claudina Zaldivar Muñoz
CPC分类号： C07K7/06 , A23K20/147 , A23K20/168 , A23K20/184 , A23K50/80 , A61K38/08 , A61K38/25
摘要： The invention is related with the chemical synthesis for increase the growth rate in marketable fish and crustaceanThe aim of this invention is supply GHRP-6 to induce directly or indirectly the release of growthing hormone or like, to produce the increase of circulating growthing hormone level in the blood of the fishes. The peptide is stable, soluble and biologically active.The peptide is able to stimulate growth, improve the larvae quality, and increase the defense against pathogen agents, the dry weight, the protein concentration and the RNA in muscle of fish and crustaceans.
摘要翻译： 本发明涉及用于增加可销售鱼类和甲壳类动物生长速率的化学合成本发明的目的是提供GHRP-6直接或间接诱导生长激素等的释放，以产生循环生长激素水平的增加 在鱼的血中。 该肽是稳定的，可溶的和生物活性的。 该肽能够刺激生长，提高幼虫质量，增加对鱼和甲壳类动物肌肉的病原体，干重，蛋白质浓度和RNA的防御。
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2.发明授权公开(公告)号：US08367620B2
公开(公告)日：2013-02-05
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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3.发明授权Pharmaceutical combination for the treatment of tissue damage owing to an arterial irrigation defect 有权用于治疗由于动脉灌注缺损引起的组织损伤的药物组合公开(公告)号：US07361638B2
公开(公告)日：2008-04-22
申请号：US10220750
申请日：2001-12-17
申请人： Jorge Berlanga Acosta , Gerardo Enrique Guillen Nieto , Diana Garcia Del Barco Herrera , Julio Raul Fernandez Masso , Mario Pablo Estrada Garcia , Isabel Guillen Perez , Jose Suarez Alba , Rebeca Martinez Rodriguez
发明人： Jorge Berlanga Acosta , Gerardo Enrique Guillen Nieto , Diana Garcia Del Barco Herrera , Julio Raul Fernandez Masso , Mario Pablo Estrada Garcia , Isabel Guillen Perez , Jose Suarez Alba , Rebeca Martinez Rodriguez
IPC分类号： A61K38/08 , A61K38/18 , C07K14/485 , C07K14/495
CPC分类号： A61K38/1841 , A61K38/08 , A61K38/1808 , A61K38/25 , A61K38/27 , A61K2300/00
摘要： This invention relates to a medicine for humans, and particularly to a pharmaceutical combination comprising Epidermal Growth Factor (EGF) and Growth Hormone secretagogue hexapeptide (GHRP) for use in preventing tissue damage due to blood flow suppression by enhancing tissue repair following ischemic damage. The aforementioned combination may be applied as a single pharmaceutical composition. Alternatively, an individual may also receive both EGF and GHRP in a separate manner but within a single therapeutic regime to enhance cellular survival when organs are subjected to blood flow deprivation for a critical period of time. This combination attenuates reactive oxygen species (ROS) formation and its associated cytotoxicity. It is also useful in promoting cellular survival when tissue or organs are exposed to prolonged ischemic periods. The combination is useful as a prophylactic agent in those subjects prone to multiple organ failure (MOF) such as burn victims, multiple trauma patients, hypoxic neonates, acute respiratory distress syndrome patients, and necrotizing enterocolitis patients.
摘要翻译： 本发明涉及用于人的药物，特别涉及包含表皮生长因子（EGF）和生长激素促分泌素六肽（GHRP）的药物组合，用于通过增强缺血性损伤后的组织修复来预防由于血流抑制引起的组织损伤。 上述组合可以作为单一药物组合物使用。 或者，个体也可以以单独的方式接受EGF和GHRP，但是在单一治疗方案内，以便当器官在关键时间段内遭受血流剥夺时增强细胞存活。 这种组合减弱活性氧（ROS）形成及其相关的细胞毒性。 当组织或器官暴露于长时间缺血期时，它也可促进细胞存活。 该组合在易受多器官功能衰竭（MOF）的受试者，如烧伤受试者，多发性创伤患者，缺氧新生儿，急性呼吸窘迫综合征患者和坏死性小肠结肠炎患者中的预防剂是有用的。
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4.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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