公开(公告)号：US07374766B1

公开(公告)日：2008-05-20

申请号：US09857402

申请日：1999-12-01

申请人： Julio César Aguilar Rubido ,  Daniel O. Palenzuela Gardón ,  Verena L. Muzio González ,  Gerardo E. Guillén Nieto ,  Eduardo Pentón Arias ,  Dagmara Pichardo Díaz ,  Enrique Iglesias Perez

发明人： Julio César Aguilar Rubido ,  Daniel O. Palenzuela Gardón ,  Verena L. Muzio González ,  Gerardo E. Guillén Nieto ,  Eduardo Pentón Arias ,  Dagmara Pichardo Díaz ,  Enrique Iglesias Perez

IPC分类号： A61K39/29 ,  A61K39/00 ,  A61K39/12

CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55583 ,  A61K2039/57 ,  A61K2039/70 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2730/10134

摘要： The present invention is related to the branch of medicine, particularly to the new formulations of vaccine antigens.The technical objective pursued with the present invention is, precisely, the development of formulations that are able to enhance the immune response to mucosally administered antigens, minimising the number of compounds in the formulation and generating strong mucosal and systemic responses through a synergic interaction between the antigens in the formulation.These formulations enable: a) to broaden the spectrum of the anti-hepatitis B immune response, containing as main compounds HBsAg and HBcAg, b) to enhance the response against HBsAg with a viral nucleocapsid c) to generate combined vaccines through the mucosal route with HBsAg as a central antigen. Stabilizers and preservatives can be introduced.The formulations of this invention can be applied in the pharmaceutical industry as human or veterinary vaccine formulations.

摘要翻译： 本发明涉及药物分支，特别是涉及疫苗抗原的新制剂。 本发明所追求的技术目标正是开发能够增强对粘膜施用抗原的免疫应答的制剂，使制剂中化合物的数量最小化，并通过协同相互作用产生强烈的粘膜和系统反应 制剂中的抗原。 这些配方能够：a）扩大抗乙型肝炎免疫反应的谱，含有主要化合物HBsAg和HBcAg，b）通过病毒核衣壳c）增强对HBsAg的反应c）通过粘膜途径产生组合疫苗， HBsAg作为中枢抗原。 可以引入稳定剂和防腐剂。 本发明的制剂可以作为人或兽用疫苗制剂应用于制药工业。

公开(公告)号：US20100093616A1

公开(公告)日：2010-04-15

申请号：US11885330

申请日：2006-02-24

申请人： Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  Jorge Amador Berlanga Acosta ,  Freya de los Milagros Freyre Almeida ,  Danay Cibrian Vera ,  Eduardo Pentón Arias

发明人： Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  Jorge Amador Berlanga Acosta ,  Freya de los Milagros Freyre Almeida ,  Danay Cibrian Vera ,  Eduardo Pentón Arias

IPC分类号： A61K38/18

CPC分类号： A61K38/08 ,  A61K38/1808 ,  A61K38/25 ,  A61K2300/00

摘要： The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.

摘要翻译： 本发明旨在刺激由于自身免疫损伤引起的中枢神经系统的神经再生。 特别地，包含治疗有效浓度的表皮生长因子和生长激素释放肽-6的药物组合被施用于患有多发性硬化症和视神经脊髓炎症状的受试者，并且校正由中枢神经中的自身反应性细胞引起的脱髓鞘 系统。