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公开(公告)号：US20110269673A1
公开(公告)日：2011-11-03
申请号：US13170975
申请日：2011-06-28
申请人： Deborah O'Neil
发明人： Deborah O'Neil
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0817 , C07K14/4723 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n (I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
摘要翻译： 本发明涉及包含根据式I（（X）l（Y）m）n（I）的氨基酸的肽，其中l，m和n为0至10的整数; X和Y可以相同或不同，是选自疏水性氨基酸和/或阳离子氨基酸的氨基酸，以及用于治疗微生物感染的方法。
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公开(公告)号：US20100047186A1
公开(公告)日：2010-02-25
申请号：US12525519
申请日：2008-01-28
申请人： Deborah O'Neil
发明人： Deborah O'Neil
摘要： The invention relates to peptides, and peptide variants thereof, in which substantially all of the amino acids in the amino sequence of said peptide are the same, for use as antibacterial agents.
摘要翻译： 本发明涉及肽及其肽变体，其中所述肽的氨基序列中的基本上所有氨基酸相同，用作抗菌剂。
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公开(公告)号：US20070244044A1
公开(公告)日：2007-10-18
申请号：US11573770
申请日：2005-08-18
申请人： Deborah O'Neil
发明人： Deborah O'Neil
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0817 , C07K14/4723 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention relates to a peptide comprising amino acids according to Formula (I): ((X)l(Y)m)n wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, for use as a medicaments.
摘要翻译： 本发明涉及包含根据式（I）的氨基酸的肽：（（X）1（Y）m）n N n其中 l，m和n为0〜10的整数; X和Y可以相同或不同，是选自疏水性氨基酸和/或阳离子氨基酸的氨基酸，用作药物。
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4.发明授权公开(公告)号：US08470769B2
公开(公告)日：2013-06-25
申请号：US13308479
申请日：2011-11-30
申请人： Deborah O'Neil
发明人： Deborah O'Neil
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0817 , C07K14/4723 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n (I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
摘要翻译： 本发明涉及包含根据式I（（X）l（Y）m）n（I）的氨基酸的肽，其中l，m和n为0至10的整数; X和Y可以相同或不同，是选自疏水性氨基酸和/或阳离子氨基酸的氨基酸，以及用于治疗微生物感染的方法。
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公开(公告)号：US20130109049A1
公开(公告)日：2013-05-02
申请号：US13517230
申请日：2010-12-20
申请人： Deborah O'Neil , Derry Mercer , Colin Stewart
发明人： Deborah O'Neil , Derry Mercer , Colin Stewart
CPC分类号： C12Q1/18 , C12Q1/24 , G01N33/5088
摘要： The present invention provides a method of infecting a nail fragment with a fungus, to form an infected nail fragment comprising at least 1×102 fungal colony forming units (cfu) per cm2 of the infected surface(s). There is also provided a method of assessing the efficacy of potential therapeutic compounds in the treatment or prevention of a fungal nail infection. The fungal nail infection may be a dermatophyte, a non-dermatophyte mould or a pathogen.
摘要翻译： 本发明提供了用真菌感染指甲片的方法，以形成感染的指甲片，其包含每cm 2感染表面至少1×102个真菌集落形成单位（cfu）。 还提供了一种评估潜在治疗化合物在治疗或预防真菌指甲感染中的功效的方法。 真菌指甲感染可以是皮肤癣菌，非皮肤癣菌霉菌或病原体。
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公开(公告)号：US20130102524A1
公开(公告)日：2013-04-25
申请号：US13638436
申请日：2011-03-30
申请人： Deborah O'Neil , Derry Mercer , Cedric Charrier
发明人： Deborah O'Neil , Derry Mercer , Cedric Charrier
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K31/145 , A61K38/08 , A61K38/10 , A61K45/06 , Y02A50/469 , Y02A50/473 , Y02A50/475 , A61K2300/00
摘要： The present invention relates to peptides and their use in the treatment of microbial infections, in particular bacterial infections. In particular, the invention relates to peptides wherein at least 75% of the amino acids of the peptide are arginine and phenylalanine amino acids, at least 50% of the amino acids being arginine amino acids and at least 15% of the amino acids being phenylalanine amino acids.
摘要翻译： 本发明涉及肽及其在治疗微生物感染，特别是细菌感染中的用途。 特别地，本发明涉及肽，其中至少75％的肽的氨基酸是精氨酸和苯丙氨酸氨基酸，至少50％的氨基酸是精氨酸氨基酸，并且至少15％的氨基酸是苯丙氨酸 氨基酸。
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公开(公告)号：US20120328671A1
公开(公告)日：2012-12-27
申请号：US13486778
申请日：2012-06-01
申请人： Deborah O'Neil , Cedric Charrier
发明人： Deborah O'Neil , Cedric Charrier
IPC分类号： A61K31/7036 , A61P31/04 , A61P31/00 , A61K9/00 , A61K38/12 , A61K31/496
CPC分类号： A61K31/7036 , A61K31/145 , A61K31/496 , A61K38/12 , A61K2300/00
摘要： The invention relates to products comprising an antibiotic agent and a second agent being a dispersant or an anti-adhesive agent, in particular a mucolytic dispersant or a mucolytic anti-adhesive agent, which are useful in relation to the prevention and treatment of bacterial infections.
摘要翻译： 本发明涉及包含抗生素剂和作为分散剂或抗粘剂的第二药剂，特别是粘液溶解分散剂或粘液溶解性抗粘剂的产品，其可用于预防和治疗细菌感染。
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公开(公告)号：US20120071398A1
公开(公告)日：2012-03-22
申请号：US13308479
申请日：2011-11-30
申请人： Deborah O'Neil
发明人： Deborah O'Neil
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0817 , C07K14/4723 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n (I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
摘要翻译： 本发明涉及包含根据式I（（X）l（Y）m）n（I）的氨基酸的肽，其中l，m和n为0至10的整数; X和Y可以相同或不同，是选自疏水性氨基酸和/或阳离子氨基酸的氨基酸，以及用于治疗微生物感染的方法。
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公开(公告)号：US08088888B2
公开(公告)日：2012-01-03
申请号：US12893663
申请日：2010-09-29
申请人： Deborah O'Neil
发明人： Deborah O'Neil
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0817 , C07K14/4723 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n (I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
摘要翻译： 本发明涉及包含根据式I（（X）l（Y）m）n（I）的氨基酸的肽，其中l，m和n为0至10的整数; X和Y可以相同或不同，是选自疏水性氨基酸和/或阳离子氨基酸的氨基酸，以及用于治疗微生物感染的方法。
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公开(公告)号：US20110021415A1
公开(公告)日：2011-01-27
申请号：US12893663
申请日：2010-09-29
申请人： DEBORAH O'NEIL
发明人： DEBORAH O'NEIL
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0817 , C07K14/4723 , Y02A50/401 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n (I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
摘要翻译： 本发明涉及包含根据式I（（X）l（Y）m）n（I）的氨基酸的肽，其中l，m和n为0至10的整数; X和Y可以相同或不同，是选自疏水性氨基酸和/或阳离子氨基酸的氨基酸，以及用于治疗微生物感染的方法。
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