知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

56 条记录 (耗时 0.029 秒)

    CUSTOMIZED USER INTERFACE FOR SUBORDINATE USERS
    2.
    发明申请
    CUSTOMIZED USER INTERFACE FOR SUBORDINATE USERS 有权
    自定义用户界面用于次要用户

    公开(公告)号：US20130097537A1

    公开(公告)日：2013-04-18

    申请号：US13613825

    申请日：2012-09-13

    申请人： Jeffrey David Kimball ,  John Thurston Wassom, JR. ,  Christina Ann Rank Dolan

    发明人： Jeffrey David Kimball ,  John Thurston Wassom, JR. ,  Christina Ann Rank Dolan

    IPC分类号： G06F3/0481

    CPC分类号： G06F3/048 ,  G06F3/0481 ,  G06F3/0484 ,  G06F17/30867 ,  G06F17/30899 ,  Y10S707/99939 ,  Y10S707/99943

    摘要： A user interface including one or more references to content is customized. Several user profiles are provided from which a user may be associated. Each user profile includes user profile information. The user profile associated with a user to whom a user interface will be provided is accessed. A user interface is configured for the user, based at least in part upon the user profile accessed as being associated with the user. Access to content is enabled based on user manipulation of the configured user interface.

    摘要翻译： 包括对内容的一个或多个引用的用户界面被定制。 提供了几个用户简档，用户可以从其中关联。 每个用户简档包括用户简档信息。 访问与要提供用户界面的用户相关联的用户简档。 至少部分地基于被访问为与用户相关联的用户简档来为用户配置用户界面。 基于用户操作配置的用户界面启用对内容的访问。

    CUSTOMIZING USER INTERFACES
    3.
    发明申请
    CUSTOMIZING USER INTERFACES 有权
    自定义用户界面

    公开(公告)号：US20130097536A1

    公开(公告)日：2013-04-18

    申请号：US13613763

    申请日：2012-09-13

    申请人： Jeffrey David Kimball ,  John Thurston Wassom, JR. ,  Christina Ann Rank Dolan

    发明人： Jeffrey David Kimball ,  John Thurston Wassom, JR. ,  Christina Ann Rank Dolan

    IPC分类号： G06F3/048

    CPC分类号： G06F3/048 ,  G06F3/0481 ,  G06F3/0484 ,  G06F17/30867 ,  G06F17/30899 ,  Y10S707/99939 ,  Y10S707/99943

    摘要： A user interface including one or more references to content is customized. Several user profiles are provided from which a user may be associated. Each user profile includes user profile information. The user profile associated with a user to whom a user interface will be provided is accessed. A user interface is configured for the user, based at least in part upon the user profile accessed as being associated with the user. Access to content is enabled based on user manipulation of the configured user interface.

    摘要翻译： 包括对内容的一个或多个引用的用户界面被定制。 提供了几个用户简档，用户可以从其中关联。 每个用户简档包括用户简档信息。 访问与要提供用户界面的用户相关联的用户简档。 至少部分地基于被访问为与用户相关联的用户简档，为用户配置用户界面。 基于用户操作配置的用户界面启用对内容的访问。

    Process for preparing arylacetylaminothiazoles
    6.
    发明授权
    Process for preparing arylacetylaminothiazoles 有权
    制备芳基乙酰氨基噻唑的方法

    公开(公告)号：US06613911B2

    公开(公告)日：2003-09-02

    申请号：US10067723

    申请日：2002-02-05

    申请人： Bang-Chi Chen ,  Kyoung S. Kim ,  S. David Kimball ,  Raj N. Misra ,  Joseph E. Sundeen ,  Rulin Zhao

    发明人： Bang-Chi Chen ,  Kyoung S. Kim ,  S. David Kimball ,  Raj N. Misra ,  Joseph E. Sundeen ,  Rulin Zhao

    IPC分类号： C07D41712

    CPC分类号： C07D417/12 ,  A61K31/427 ,  A61K31/454 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D417/14

    摘要： The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula I: or a pharmnaceutically acceptable salt thereof, wherein: R1, R2, R4, R5, R6, R8, R9, R12 and R13 are each independently hydrogen, alkyl, aryl or heteroaryl; R3, R7, R10 and R11 are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy; and X is CH or N, which are novel, potent inhibitors of cyclin dependent kinases (cdks). The present invention also concerns a new process for the preparation of formylarylacetates and formylarylacetic acids.

    摘要翻译： 本发明涉及制备式I的5-（2-恶唑基烷硫基）-2-芳基乙酰氨基噻唑化合物的新的，有效的方法：或其药物上可接受的盐，其中：R1，R2，R4，R5，R6，R8， R9，R12和R13各自独立地为氢，烷基，芳基或杂芳基; R3，R7，R10和R11各自独立地为氢，烷基，芳基，杂芳基，卤素，羟基或烷氧基; 而X是CH或N，它们是细胞周期蛋白依赖性激酶（cdks）的新型有效抑制剂。 本发明还涉及制备甲酰芳基乙酸酯和甲酰芳基乙酸的新方法。

    Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors
    7.
    发明授权
    Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors 有权
    吡唑并[3,4-b]吡啶作为细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号：US6107305A

    公开(公告)日：2000-08-22

    申请号：US209575

    申请日：1998-12-11

    申请人： Raj N. Misra ,  S. David Kimball ,  David B. Rawlins ,  Kevin R. Webster ,  Isia Bursuker

    发明人： Raj N. Misra ,  S. David Kimball ,  David B. Rawlins ,  Kevin R. Webster ,  Isia Bursuker

    IPC分类号： A61K31/437 ,  A61P1/00 ,  A61P19/02 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P31/10 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D471/04 ,  A61K31/435

    CPC分类号： C07D471/04 ,  A61K31/437

    摘要： Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein:X is O, S(O).sub.m ;Y is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl;R.sub.1 is hydrogen or lower alkyl;R.sub.2 is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, --O-alkyl, --O-aryl, --NR.sub.4 R.sub.5 ;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, --O-alkyl, --O-aryl;R.sub.5 is hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, cycloalkyl, alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, --O-alkyl, --O-aryl; andm is 0, 1 or 2.The compounds of formula I are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, cardiovascular diseases, viral diseases and fungal diseases.

    摘要翻译： 用作细胞周期依赖性激酶抑制剂的式及其可药用盐的化合物，其中：X为O，S（O）m; Y是烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，环烷基烷基，杂环烷基，杂环烷基烷基; R1是氢或低级烷基; R2是烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，环烷基烷基，杂环烷基，杂环烷基烷基，-O-烷基，-O-芳基，-NR4R5; R3是氢或低级烷基; R4是氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，环烷基烷基，杂环烷基，杂环烷基烷基，-O-烷基，-O-芳基。 R5是氢，烷基，芳基，烷基芳基，杂芳基，烷基杂芳基，环烷基，烷基环烷基，杂环烷基，烷基杂环烷基，-O-烷基，-O-芳基; 并且m为0,1或2.式I化合物为蛋白激酶抑制剂，可用于治疗和预防增殖性疾病，例如癌症，炎症和关节炎。 它们也可用于治疗神经变性疾病如阿尔茨海默病，心血管疾病，病毒性疾病和真菌性疾病。