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公开(公告)号：US09365602B2
公开(公告)日：2016-06-14
申请号：US13925981
申请日：2013-06-25
IPC分类号： C07H15/14 , A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
摘要翻译： 公开了基于硫代烷基 - 四氢吡喃的化合物，包含它们的药物组合物及其用于治疗疾病和病症如糖尿病和肥胖症的方法。
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2.发明授权公开(公告)号：US08450332B2
公开(公告)日：2013-05-28
申请号：US13486122
申请日：2012-06-01
申请人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
发明人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
IPC分类号： A01N43/60 , A61K31/519
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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3.发明申请公开(公告)号：US20120329818A1
公开(公告)日：2012-12-27
申请号：US13486122
申请日：2012-06-01
申请人： Hugh Alfred BURGOON , Nicole Cathleen GOODWIN , Bryce Alden HARRISON , Jason Patrick HEALY , Ying LIU , Ross MABON , Brett MARINELLI , David Brent RAWLINS , Dennis Stewart RICE , Norris Andrew WHITLOCK
发明人： Hugh Alfred BURGOON , Nicole Cathleen GOODWIN , Bryce Alden HARRISON , Jason Patrick HEALY , Ying LIU , Ross MABON , Brett MARINELLI , David Brent RAWLINS , Dennis Stewart RICE , Norris Andrew WHITLOCK
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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4.发明授权Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use 有权基于哌啶基的钠葡萄糖共转运蛋白2的抑制剂及其使用方法公开(公告)号：US07846945B2
公开(公告)日：2010-12-07
申请号：US12041860
申请日：2008-03-04
IPC分类号： A61K31/451 , A61K31/4523 , C07D401/02 , C07D405/02 , C07D407/02 , C07D409/02 , C07D411/02 , C07D413/02 , C07D417/02 , C07D419/02 , C07D421/02 , C07D211/42 , C07D211/46
CPC分类号： C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12
摘要： Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
摘要翻译： 公开了包含它们的化合物和药物组合物，其可用于治疗诸如糖尿病和肥胖症的疾病和病症。
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5.发明授权公开(公告)号：US08193202B2
公开(公告)日：2012-06-05
申请号：US12426661
申请日：2009-04-20
申请人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
发明人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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公开(公告)号：US20100311673A1
公开(公告)日：2010-12-09
申请号：US12858666
申请日：2010-08-18
IPC分类号： A61K31/7028 , C07H15/04 , C07D309/10 , C07C251/16 , C07D211/46 , C07D335/02 , A61K31/351 , A61K31/138 , A61K31/451 , A61K31/382 , A61P3/10 , A61P9/12 , A61P3/00 , A61P3/04 , A61P9/00 , A61P9/10 , A61P5/50 , G01N33/50
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
摘要翻译： 公开了基于硫代烷基 - 四氢吡喃的化合物，包含它们的药物组合物及其用于治疗疾病和病症如糖尿病和肥胖症的方法。
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公开(公告)号：US08476413B2
公开(公告)日：2013-07-02
申请号：US12858666
申请日：2010-08-18
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
摘要翻译： 公开了基于硫代烷基 - 四氢吡喃的化合物，包含它们的药物组合物及其用于治疗疾病和病症如糖尿病和肥胖症的方法。
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8.发明申请5-(1H-PYRAZOL-5-YL)THIAZOLE-BASED COMPOUNDS FOR THE TREATMENT OF DISEASES AND DISORDERS OF THE EYE 审中-公开用于治疗眼睛疾病和疾病的5-（1H-吡唑-5-基）噻唑基化合物公开(公告)号：US20130059896A1
公开(公告)日：2013-03-07
申请号：US13574024
申请日：2011-01-21
IPC分类号： C07D417/04 , A61P27/06 , A61P27/02 , A61K31/427 , C07D417/14
CPC分类号： A61K31/427
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula (I)
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 特定的化合物具有式（I）
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9.发明授权公开(公告)号：US07781577B2
公开(公告)日：2010-08-24
申请号：US11862690
申请日：2007-09-27
申请人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Nicole C Goodwin
发明人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Nicole C Goodwin
IPC分类号： A61K31/7008 , A61K31/7034 , A61K31/7042 , C07H5/06 , C07H5/10 , C07H7/04 , C07H7/06
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
摘要翻译： 公开了包含它们的化合物和药物组合物，其可用于治疗诸如糖尿病和肥胖症的疾病和病症。
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10.发明申请公开(公告)号：US20090264450A1
公开(公告)日：2009-10-22
申请号：US12426661
申请日：2009-04-20
申请人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
发明人： Hugh Alfred Burgoon , Nicole Cathleen Goodwin , Bryce Alden Harrison , Jason Patrick Healy , Ying Liu , Ross Mabon , Brett Marinelli , David Brent Rawlins , Dennis Stewart Rice , Norris Andrew Whitlock
IPC分类号： A61K31/519 , C07D487/04 , A61P27/02
CPC分类号： C07D487/04
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula:
摘要翻译： 公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。 具体化合物具有下式：
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