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公开(公告)号：US20050107364A1
公开(公告)日：2005-05-19
申请号：US10925072
申请日：2004-08-24
申请人： Douglas Hutchinson , John Bellettini , David Betebenner , Richard Bishop , Thomas Borchardt , Todd Bosse , Russell Cink , Charles Flentge , Bradley Gates , Brian Green , Mira Hinman , Peggy Huang , Larry Klein , Allan Krueger , Daniel Larson , M. Leanna , Dachun Liu , Darold Madigan , Keith McDaniel , John Randolph , Todd Rockway , Teresa Rosenberg , Kent Stewart , Vincent Stoll , Rolf Wagner , Ming Yeung
发明人： Douglas Hutchinson , John Bellettini , David Betebenner , Richard Bishop , Thomas Borchardt , Todd Bosse , Russell Cink , Charles Flentge , Bradley Gates , Brian Green , Mira Hinman , Peggy Huang , Larry Klein , Allan Krueger , Daniel Larson , M. Leanna , Dachun Liu , Darold Madigan , Keith McDaniel , John Randolph , Todd Rockway , Teresa Rosenberg , Kent Stewart , Vincent Stoll , Rolf Wagner , Ming Yeung
IPC分类号： A61K31/549 , C07D285/26
CPC分类号： C07D207/08 , C07C323/22 , C07C323/56 , C07C323/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D263/14 , C07D285/24 , C07D417/06 , C07D417/08 , C07D417/12 , C07D513/04 , C07F9/6547
摘要： Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译： 具有下式的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶，制备该化合物的方法和该方法中使用的合成中间体的组合物和方法。
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公开(公告)号：US20070197558A1
公开(公告)日：2007-08-23
申请号：US11613825
申请日：2006-12-20
申请人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号： A61K31/519 , C07D498/02 , C07D487/02
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译： 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：US20050075331A1
公开(公告)日：2005-04-07
申请号：US10679881
申请日：2003-10-06
申请人： John Pratt , David Betebenner , Pamela Donner , Brian Green , Dale Kempf , Keith McDaniel , Clarence Maring , Vincent Stoll , Rong Zhang
发明人： John Pratt , David Betebenner , Pamela Donner , Brian Green , Dale Kempf , Keith McDaniel , Clarence Maring , Vincent Stoll , Rong Zhang
IPC分类号： C07D213/69 , C07D215/22 , C07D401/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07D519/00 , C07D285/26 , A61K31/549 , C07D285/22
CPC分类号： C07D213/69 , C07D215/22 , C07D401/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
摘要翻译： 本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供了抑制丙型肝炎病毒（HCV）聚合酶，抑制HCV病毒复制的方法以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。
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公开(公告)号：US20080139811A1
公开(公告)日：2008-06-12
申请号：US11679227
申请日：2007-02-27
申请人： Hing Sham , Daniel Norbeck , Xiaoqi Chen , David Betebenner , Dale Kempf , Thomas Herrin , Gondi Kumar , Stephen Condon , Arthur Cooper , Daniel Dickman , Steven Hannick , Lawrence Kolaczkowski , Patricia Oliver , Daniel Plata , Peter Stengel , Eric Stoner , Jieh-Heh Tien , Jih-Hua Liu , Ketan Patel
发明人： Hing Sham , Daniel Norbeck , Xiaoqi Chen , David Betebenner , Dale Kempf , Thomas Herrin , Gondi Kumar , Stephen Condon , Arthur Cooper , Daniel Dickman , Steven Hannick , Lawrence Kolaczkowski , Patricia Oliver , Daniel Plata , Peter Stengel , Eric Stoner , Jieh-Heh Tien , Jih-Hua Liu , Ketan Patel
IPC分类号： C07D239/10 , C07D233/32
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译： 公开了下式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号：US20070232645A1
公开(公告)日：2007-10-04
申请号：US11613836
申请日：2006-12-20
申请人： Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
发明人： Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
IPC分类号： A61K31/4375 , C07D471/02 , C12N7/06
CPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号：US20070232627A1
公开(公告)日：2007-10-04
申请号：US11613810
申请日：2006-12-20
申请人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号： A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC分类号： C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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