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    Modulators of the abc transporter family and methods for their use
    3.
    发明申请
    Modulators of the abc transporter family and methods for their use 审中-公开
    abc转运体家族的调节剂及其使用方法

    公开(公告)号：US20070105766A1

    公开(公告)日：2007-05-10

    申请号：US10575577

    申请日：2004-10-14

    申请人： Bruce Staton ,  George O'Toole ,  Agnieszka Swiatecka-Urban ,  Daniel MacEachran ,  Sophie Marquis

    发明人： Bruce Staton ,  George O'Toole ,  Agnieszka Swiatecka-Urban ,  Daniel MacEachran ,  Sophie Marquis

    IPC分类号： A61K38/16

    CPC分类号： A61K38/164 ,  A61K45/06 ,  C07K14/21

    摘要： An isolated factor derived from the bacterium Pseudomonas aeruginosa that reduces expression of ABC transmembrane proteins and active fragments and mimetics thereof are provided. Also provided is a method for inhibiting expression of ABC transmembrane proteins in cells by administering to the cells the isolated factor or active fragment or a mimetic thereof. Such methods are useful in the enhancing delivery of small molecule therapeutic agents to the CNS and in treating cancers, particularly multidrug resistant cancers, and secretory diarrhea. In addition, compositions, methods for identifying compositions and methods for use of compositions which inhibit suppression of ABC transmembrane protein expression by this factor are provided. Such compositions and methods are useful in treatment of cystic fibrosis.

    摘要翻译： 提供了从细菌铜绿假单胞菌衍生的分离因子，其减少ABC跨膜蛋白及其活性片段及其模拟物的表达。 还提供了通过向细胞施用分离的因子或活性片段或其模拟物来抑制细胞中ABC跨膜蛋白的表达的方法。 这些方法可用于增强小分子治疗剂向CNS的输送和治疗癌症，特别是多药耐药性癌症和分泌性腹泻。 另外，提供了组合物，用于鉴定组合物的方法和使用抑制ABC跨膜蛋白表达抑制因子的组合物的方法。 这些组合物和方法可用于治疗囊性纤维化。