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公开(公告)号：US08748596B2
公开(公告)日：2014-06-10
申请号：US13257224
申请日：2010-03-17
申请人： Diego Broggini , Vit Lellek , Susanne Lochner , Neelakandha S. Mani , Adrian Maurer , Daniel J. Pippel , Lana K. Young
发明人： Diego Broggini , Vit Lellek , Susanne Lochner , Neelakandha S. Mani , Adrian Maurer , Daniel J. Pippel , Lana K. Young
IPC分类号： C07D401/02 , C07D401/14
CPC分类号： C07D213/82 , C07B2200/13 , C07D405/12
摘要： The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
摘要翻译： 本发明涉及用于制备组胺H3受体调节剂在治疗例如认知障碍，睡眠障碍和/或精神疾病中的新方法。
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2.发明申请BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR 有权作为组胺H4受体的调节剂的苯并咪唑基-2-YL吡啶和吡咯烷公开(公告)号：US20100256373A1
公开(公告)日：2010-10-07
申请号：US12816995
申请日：2010-06-16
申请人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
发明人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/4184 , C07D403/14
摘要： Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 苯并咪唑-2-基嘧啶和吡嗪，用于H 4受体活性调节和用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，包括变态反应，哮喘，自身免疫性疾病和瘙痒症。
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3.发明申请公开(公告)号：US20090291903A1
公开(公告)日：2009-11-26
申请号：US12468632
申请日：2009-05-19
申请人： Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人： Nicholas I. Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号： A61K38/05 , C07D403/06 , A61K31/551
CPC分类号： C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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4.发明申请Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor 审中-公开苯并咪唑-2-基嘧啶和吡嗪作为组胺H 4受体的调节剂公开(公告)号：US20090137608A1
公开(公告)日：2009-05-28
申请号：US12321208
申请日：2009-01-15
申请人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
发明人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
IPC分类号： A61K31/506 , A61K31/497
CPC分类号： C07D401/14 , A61K31/4184 , C07D403/14
摘要： Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 苯并咪唑-2-基嘧啶和吡嗪，用于H 4受体活性调节和用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，包括变态反应，哮喘，自身免疫性疾病和瘙痒症。
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![Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators](/abs-image/US/2014/02/18/US08653263B2/abs.jpg.150x150.jpg)
5.发明授权Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators 有权二取代八氢吡咯并[3,4-c]吡咯作为食欲素受体调节剂公开(公告)号：US08653263B2
公开(公告)日：2014-02-18
申请号：US13503231
申请日：2010-10-21
申请人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
发明人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
IPC分类号： C07D417/00 , C07D239/02 , C07D241/36 , C07D215/38 , A61K31/4965 , A61K31/515 , A61K31/44 , A61K31/425
CPC分类号： C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
摘要翻译： 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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公开(公告)号：US20120259130A1
公开(公告)日：2012-10-11
申请号：US13526995
申请日：2012-06-19
申请人： Luigi Anzalone , Daniel J. Pippel , Neelakandha S. Mani , Penina Feibush , IIias K. Dorziotis , Stefan Horns , Frank J. Villani, JR.
发明人： Luigi Anzalone , Daniel J. Pippel , Neelakandha S. Mani , Penina Feibush , IIias K. Dorziotis , Stefan Horns , Frank J. Villani, JR.
IPC分类号： C07F9/6553
CPC分类号： C07F9/655354 , C07F9/301 , C07F9/3808 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/6541 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/657181
摘要： The present invention is directed to an improved process for synthesizing phosphonic and phosphinic acid chymase inhibitor compounds.
摘要翻译： 本发明涉及一种用于合成膦酸和次膦酸糜酶抑制剂化合物的改进方法。
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7.发明授权公开(公告)号：US08236792B2
公开(公告)日：2012-08-07
申请号：US12468632
申请日：2009-05-19
申请人： Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
发明人： Nicholas I Carruthers , Michael A. Letavic , Kiev S. Ly , Neelakandha S. Mani , Daniel J. Pippel , Chandravadan R. Shah , Akinola Soyode-Johnson , Emily M. Stocking , Lana Young
IPC分类号： A61K31/55 , A61K31/497 , A61K31/445 , A61K31/40 , C07D243/08 , C07D403/00 , C07D401/00 , C07D205/00
CPC分类号： C07D403/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吡咯烷酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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8.发明申请公开(公告)号：US20100029942A1
公开(公告)日：2010-02-04
申请号：US12459224
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号： C07D401/14
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译： 本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。
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公开(公告)号：US20100004450A1
公开(公告)日：2010-01-07
申请号：US12459229
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
IPC分类号： C07D401/12 , C07D211/22 , C07D211/26
CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26
摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
摘要翻译： 本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法，以及H4调节剂合成中的中间体。
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![DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS](/abs-image/US/2012/08/16/US20120208812A1/abs.jpg.150x150.jpg)
10.发明申请DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS 有权作为OREXIN受体调节剂的分析的甲氧基吡咯并[3,4-c]吡咯公开(公告)号：US20120208812A1
公开(公告)日：2012-08-16
申请号：US13503231
申请日：2010-10-21
申请人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
发明人： Wenying Chai , Michael A. Letavic , Kiev S. Ly , Daniel J. Pippel , Dale A. Rudolph , Kathleen C. Sappey , Brad M. Savall , Chandravadan R. Shah , Brock T. Shireman , Akinola Soyode-Johnson , Emily M. Stocking , Devin M. Swanson
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/517 , A61K31/506 , A61K31/444 , A61K31/428 , A61K31/423 , C07D487/04 , A61P25/20 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/22 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P15/00 , A61P19/02 , A61P9/00 , A61P1/04 , A61P1/00 , A61P1/12 , A61K31/53
CPC分类号： C07D487/04 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
摘要翻译： 描述了二取代八氢吡咯并[3,4-c]吡咯化合物，其可用作食欲素受体调节剂。 这样的化合物可用于治疗由食欲素活性（例如失眠）介导的疾病状态，病症和病症的药物组合物和方法。
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