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1.发明申请公开(公告)号：US20100029942A1
公开(公告)日：2010-02-04
申请号：US12459224
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号： C07D401/14
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译： 本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。
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公开(公告)号：US20100004450A1
公开(公告)日：2010-01-07
申请号：US12459229
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
IPC分类号： C07D401/12 , C07D211/22 , C07D211/26
CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26
摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
摘要翻译： 本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法，以及H4调节剂合成中的中间体。
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公开(公告)号：US06593493B1
公开(公告)日：2003-07-15
申请号：US09662211
申请日：2000-09-14
申请人： Robert J. Ardecky , Marcus F. Boehm , Amy L. Faulkner , Lawrence G. Hamann , Todd K. Jones , Christopher M. Mapes , Pierre-Yves Michellys , John S. Tyhonas , Anthony W. Thompson , Jyun-Hung Chen
发明人： Robert J. Ardecky , Marcus F. Boehm , Amy L. Faulkner , Lawrence G. Hamann , Todd K. Jones , Christopher M. Mapes , Pierre-Yves Michellys , John S. Tyhonas , Anthony W. Thompson , Jyun-Hung Chen
IPC分类号： C07C5500
CPC分类号： C07D333/24 , C07C59/64 , C07C59/72 , C07D213/55 , C07D307/54
摘要： The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also provides synthetic methods for preparing these compounds as well as pharmaceutical compositions incorporating these novel compounds and methods for the therapeutic use of such compounds and pharmaceutical compositions.
摘要翻译： 本发明提供了一类新的RXR调节剂化合物，其相对于先前研究的RXR调节剂的谱图显示出改善的药理学特征，包括与目前要求保护的调节剂共享共同结构特征的RXR调节剂。 本发明还提供了制备这些化合物的合成方法以及掺入这些新化合物的药物组合物和用于治疗性使用这些化合物和药物组合物的方法。
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公开(公告)号：US08921550B2
公开(公告)日：2014-12-30
申请号：US13427798
申请日：2012-03-22
IPC分类号： C07D401/14 , C07D403/04
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
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公开(公告)号：US08309720B2
公开(公告)日：2012-11-13
申请号：US12459229
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
IPC分类号： C07D211/06 , C07D211/30
CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26
摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
摘要翻译： 本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法，以及H4调节剂合成中的中间体。
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6.发明申请公开(公告)号：US20120178932A1
公开(公告)日：2012-07-12
申请号：US13427767
申请日：2012-03-22
申请人： Sergio CESCO-CANCIAN , Jeffrey S. GRIMM , Neelakandha S. MANI , Christopher M. MAPES , David C. PALMER , Daniel J. PIPPEL , Tong XIAO , Diego BROGGINI , Susanne LOCHNER
发明人： Sergio CESCO-CANCIAN , Jeffrey S. GRIMM , Neelakandha S. MANI , Christopher M. MAPES , David C. PALMER , Daniel J. PIPPEL , Tong XIAO , Diego BROGGINI , Susanne LOCHNER
IPC分类号： C07D401/14
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译： 本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。
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7.发明授权Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor 有权苯并咪唑-2-基嘧啶和吡嗪作为组胺H 4受体的调节剂公开(公告)号：US07507737B2
公开(公告)日：2009-03-24
申请号：US11731074
申请日：2007-03-30
申请人： James P. Edwards , David E. Kindrachuk , Christopher M. Mapes , Daniel J. Pippel , Jennifer D. Venable
发明人： James P. Edwards , David E. Kindrachuk , Christopher M. Mapes , Daniel J. Pippel , Jennifer D. Venable
IPC分类号： C07D401/14 , A61K31/4184
CPC分类号： C07D401/14 , A61K31/4184 , C07D403/14
摘要： Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 苯并咪唑-2-基嘧啶和吡嗪，用于治疗由H 4受体活性介导的疾病状态，病症和病况的药物组合物和方法，包括变态反应，哮喘，自身免疫疾病和瘙痒症。
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8.发明申请BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR 有权作为组胺H4受体的调节剂的苯并咪唑基-2-YL吡啶和吡咯烷公开(公告)号：US20100256373A1
公开(公告)日：2010-10-07
申请号：US12816995
申请日：2010-06-16
申请人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
发明人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/4184 , C07D403/14
摘要： Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 苯并咪唑-2-基嘧啶和吡嗪，用于H 4受体活性调节和用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，包括变态反应，哮喘，自身免疫性疾病和瘙痒症。
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9.发明申请Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor 审中-公开苯并咪唑-2-基嘧啶和吡嗪作为组胺H 4受体的调节剂公开(公告)号：US20090137608A1
公开(公告)日：2009-05-28
申请号：US12321208
申请日：2009-01-15
申请人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
发明人： James P. EDWARDS , David E. KINDRACHUK , Christopher M. MAPES , Daniel J. PIPPEL , Jennifer D. VENABLE
IPC分类号： A61K31/506 , A61K31/497
CPC分类号： C07D401/14 , A61K31/4184 , C07D403/14
摘要： Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 苯并咪唑-2-基嘧啶和吡嗪，用于H 4受体活性调节和用于治疗H4受体活性介导的疾病状态，病症和病症的药物组合物和方法，包括变态反应，哮喘，自身免疫性疾病和瘙痒症。
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公开(公告)号：US07348359B2
公开(公告)日：2008-03-25
申请号：US10471330
申请日：2002-03-14
申请人： Kevin M. Gardinier , Douglas L. Gernert , Timothy A. Grese , David A. Neel , Christopher M. Mapes , Pierre-Yves Michellys , Marcus F. Boehm
发明人： Kevin M. Gardinier , Douglas L. Gernert , Timothy A. Grese , David A. Neel , Christopher M. Mapes , Pierre-Yves Michellys , Marcus F. Boehm
IPC分类号： A61K31/43 , C07D307/80 , C07D307/81
CPC分类号： C07D261/20 , C07D209/12 , C07D215/14 , C07D217/16 , C07D231/56 , C07D307/80 , C07D307/85 , C07D333/56 , C07D333/60 , C07D333/70 , C07D471/04 , C07D495/04
摘要： The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof.
摘要翻译： 本发明涉及由结构式（I）表示的化合物及其药学上可接受的盐，溶剂合物和水合物：（I）。 本发明还涉及由结构式（I）表示的药物组合物，使用方法和制备化合物的方法及其药学上可接受的盐，溶剂合物和水合物。
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