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公开(公告)号：US08685458B2
公开(公告)日：2014-04-01
申请号：US13254802
申请日：2010-03-03
申请人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel T. Smithey
发明人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel T. Smithey
IPC分类号： A61P11/00 , A61K9/14 , A61K31/721 , B82Y5/00
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0048 , A61K9/0075 , A61K9/0095 , A61K9/10 , A61K9/1652 , A61K9/19 , A61K9/5161 , A61K31/57
摘要： Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
摘要翻译： 提供包含活性剂和葡聚糖聚合物衍生物的药物组合物。 组合物包含0.01至99重量％的活性剂和1至99.99重量％的葡聚糖聚合物衍生物。 葡聚糖聚合物衍生物选自葡聚糖乙酸酯，葡聚糖丙酸酯，葡聚糖琥珀酸酯，乙酸葡聚糖丙酸酯，醋酸葡聚糖琥珀酸酯，琥珀酸葡聚糖葡聚糖，琥珀酸葡聚糖乙酸酯及其混合物。
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公开(公告)号：US20130165371A1
公开(公告)日：2013-06-27
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
IPC分类号： B01D1/20
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
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公开(公告)号：US20130153157A1
公开(公告)日：2013-06-20
申请号：US13820483
申请日：2011-09-01
IPC分类号： B01D1/20
CPC分类号： B01D1/20 , A61K9/16 , A61K9/1682 , A61K31/137 , A61K38/22 , A61K38/28 , B01D1/18 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.
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4.发明申请HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE WITH ENHANCED ACETATE AND SUCCINATE SUBSTITUTION 有权具有增强的乙酸酯和替代物的羟丙基甲基纤维素乙酸酯公开(公告)号：US20130102691A1
公开(公告)日：2013-04-25
申请号：US13702331
申请日：2011-06-13
申请人： Warren K. Miller , David K. Lyon , Dwayne T. Friesen , William B. Caldwell , David T. Vodak , Daniel E. Dobry
发明人： Warren K. Miller , David K. Lyon , Dwayne T. Friesen , William B. Caldwell , David T. Vodak , Daniel E. Dobry
IPC分类号： A61K47/38
CPC分类号： A61K47/38 , A61K9/146 , A61K31/415 , A61K31/496 , C08B13/00 , C08L1/32
摘要： Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.
摘要翻译： 公开了具有羟丙氧基，甲氧基，乙酰基和琥珀酰基具有独特取代度的羟丙基甲基纤维素乙酸琥珀酸酯（HPMCAS）的聚合物。 当用于制备包含低溶解度活性剂和这种聚合物的组合物时，聚合物提供增加的水性浓度和/或改善活性剂的物理稳定性。
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公开(公告)号：US09084944B2
公开(公告)日：2015-07-21
申请号：US13820483
申请日：2011-09-01
CPC分类号： B01D1/20 , A61K9/16 , A61K9/1682 , A61K31/137 , A61K38/22 , A61K38/28 , B01D1/18 , B01J2/04
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.
摘要翻译： 喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。 喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。 第一端部和第二端部之间的长度与干燥室内部的相对的内表面之间的最大宽度的比率可以为至少5比1。
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公开(公告)号：US20120003282A1
公开(公告)日：2012-01-05
申请号：US13254802
申请日：2010-03-03
申请人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel t. Smithey
发明人： Warren K. Miller , David T. Vodak , Daniel E. Dobry , David K. Lyon , Dwayne T. Friesen , Michael M. Morgen , Corey J. Bloom , Daniel t. Smithey
IPC分类号： A61K9/14 , A61K31/216 , A61K31/428 , A61P7/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61K31/56 , A61P29/00 , B82Y5/00
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0048 , A61K9/0075 , A61K9/0095 , A61K9/10 , A61K9/1652 , A61K9/19 , A61K9/5161 , A61K31/57
摘要： Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
摘要翻译： 提供包含活性剂和葡聚糖聚合物衍生物的药物组合物。 组合物包含0.01至99重量％的活性剂和1至99.99重量％的葡聚糖聚合物衍生物。 葡聚糖聚合物衍生物选自葡聚糖乙酸酯，葡聚糖丙酸酯，葡聚糖琥珀酸酯，乙酸葡聚糖丙酸酯，醋酸葡聚糖琥珀酸酯，琥珀酸葡聚糖葡聚糖，琥珀酸葡聚糖乙酸酯及其混合物。
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公开(公告)号：US09084976B2
公开(公告)日：2015-07-21
申请号：US13820494
申请日：2011-09-01
申请人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
发明人： Daniel E. Dobry , James M. Mullin , Douglas L. Millard , Dwayne T. Friesen , David D. Newbold , John M. Baumann , Devon B. Dubose
摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
摘要翻译： 喷雾干燥设备包括干燥室，其具有第一端，第二端和在第一和第二端之间延伸的至少一个侧壁，以限定具有中心轴线的干燥室的内部。 喷嘴可以位于干燥室的第一端处，并且被配置成雾化液体并且以相对于中心轴线的最大喷射图形角度将雾化的液体喷射到干燥室的内部。 可以提供加热装置以在引入干燥室之前加热液体。
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8.发明授权Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution 有权羟丙基甲基纤维素醋酸琥珀酸酯与乙酸和琥珀酸酯增加取代公开(公告)号：US09040033B2
公开(公告)日：2015-05-26
申请号：US13702331
申请日：2011-06-13
申请人： Warren K. Miller , David K. Lyon , Dwayne T. Friesen , William B. Caldwell , David T. Vodak , Daniel E. Dobry
发明人： Warren K. Miller , David K. Lyon , Dwayne T. Friesen , William B. Caldwell , David T. Vodak , Daniel E. Dobry
IPC分类号： A61K47/48 , A61K9/14 , A61K31/415 , A61K31/496 , C08B13/00 , C08L1/32 , A61K47/38
CPC分类号： A61K47/38 , A61K9/146 , A61K31/415 , A61K31/496 , C08B13/00 , C08L1/32
摘要： Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.
摘要翻译： 公开了具有羟丙氧基，甲氧基，乙酰基和琥珀酰基具有独特取代度的羟丙基甲基纤维素乙酸琥珀酸酯（HPMCAS）的聚合物。 当用于制备包含低溶解度活性剂和这种聚合物的组合物时，聚合物提供增加的水性浓度和/或改善活性剂的物理稳定性。
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