公开(公告)号：US20150080377A1

公开(公告)日：2015-03-19

申请号：US14016081

申请日：2013-08-31

Applicant: Daljit Singh Dhanoa

Inventor： Daljit Singh Dhanoa

IPC: C07D498/04 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/12 ,  A61K31/4709 ,  C07D495/04 ,  C07D471/04

CPC classification number: C07D498/04 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  C07D401/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention relates to deuterium-enriched pyridinonecarboxamides and their derivatives of the formula 1, and pharmaceutically acceptable salts thereof, are partial or full agonists of serotonin (5-Hydroxytryptamine or 5-HT) receptor subtype 4 (5-HT4), and are useful compounds for the prevention and treatment of Alzheimer's disease, cognitive and memory dysfunction, mild cognition impairment, memory decline, cognitive impairment associated with schizophrenia, cognitive impairment associated with age-related dementia or Alzheimer's disease, cognitive impairment associated with post-coronary bypass surgery, attention deficit hyperactivity disorder, Obsessive compulsive disorder, depression, speech improvement in autistic children, sleep apnea in Alzheimer's patients, Age-related macular degeneration (AMD), irritable bowel syndrome, gastroesophageal reflux disease, Crohn's disease, emesis, nausea, vomiting, prokinesia, non-ulcer dyspepcia, anxiety, depression, pain, migraine, urinary incontinence, arterial fibrillation, arrhythmia, ischemic stroke, gastric emptying disorders, gastritis, gastrointestinal disorders, feeding disorders, obesity, anorexia, constipation, respiratory depression, and erectile dysfunction.

Abstract translation: 本发明涉及富含氘的吡啶甲酰胺及其衍生物及其药学上可接受的盐，是5-羟色胺（5-羟色胺或5-HT）受体亚型4（5-HT4）的部分或全部激动剂，分别为 用于预防和治疗阿尔茨海默病，认知和记忆功能障碍，轻度认知障碍，记忆衰退，与精神分裂症相关的认知障碍，与年龄相关的痴呆或阿尔茨海默病相关的认知障碍，与冠状动脉搭桥手术相关的认知障碍的有用化合物 老年性黄斑变性（AMD），肠易激综合征，胃食管反流病，克罗恩病，呕吐，恶心，呕吐等症状的自闭症儿童注意力缺陷多动障碍，强迫症，抑郁症，言语改善，睡眠呼吸暂停， 运动迟缓，非溃疡性呼吸困难，焦虑，抑郁，疼痛，偏头痛，尿尿 尿失禁，动脉纤维性颤动，心律失常，缺血性中风，胃排空障碍，胃炎，胃肠道疾病，进食障碍，肥胖症，厌食症，便秘，呼吸抑制和勃起功能障碍。

公开(公告)号：US20140221395A1

公开(公告)日：2014-08-07

申请号：US13954803

申请日：2013-07-30

Applicant: Daljit Singh Dhanoa

Inventor： Daljit Singh Dhanoa

IPC: C07D295/155 ,  A61K45/06 ,  A61K31/495

CPC classification number: C07D295/155 ,  A61K31/495 ,  A61K45/06 ,  C07D295/135

Abstract: The present invention is concerned with deuterium-enriched sulfonamides of formula 1, their pharmaceutically acceptable salts and methods of use thereof for the treatment of anxiety disorders including, General Anxiety Disorder (GAD), Panic Disorder (PD), Post-Traumatic Stress Disorder (PTSD), Social Phobia (SP), Health Anxiety (Hypochondriasis), depression, major depressive disorders, unipolar depression, bipolar I depression disorder, bipolar II depression disorder, treatment-resistant depression, single episodic and recurrent major depressive disorders, depression in the medically ill, attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), Obsessive-Compulsive Disorder (OCD), Obsessive-Compulsive Personality Disorder (OCPD), Autism Spectrum Disorder (ASD), schizophrenia, psychosis, epilepsy, seizures, hot flashes due to menopause, age-related macular degeneration (AMD), premature ejaculation, male erectile dysfunction, sexual dysfunction, obesity, eating disorders, bulimia nervosa, anorexia nervosa, angina, migraine, pain, nociception, sleep disorders, insomnia, fibromyalgia, alcohol withdrawal, autism, Rett's syndrome, cyclothymic disorder, neural injury, neurodegenerative diseases, Parkinson's disease, Parkinson's disease psychosis, Huntington disease, Alzheimer's disease, frontotemporal dementia, cognitive impairment associated with age-related dementia, Alzheimer's disease, schizophrenia, psychosis, depression, pain or discomfort associated with surgery and pain or discomfort associated with medical illness.

Abstract translation: 本发明涉及式1的氘富集磺酰胺，其药学上可接受的盐及其用于治疗焦虑症的方法，包括一般性焦虑障碍（GAD），恐慌症（PD），创伤后应激障碍 PTSD），社会恐惧症（SP），健康焦虑（Hypochondriasis），抑郁症，重度抑郁障碍，单极抑郁症，双相I抑郁障碍，双相II抑郁症，耐药性抑郁症，单次发作和复发性抑郁障碍，抑郁症 注意力缺陷多动障碍（ADHD），注意力缺陷障碍（ADD），强迫症（OCD），强迫症人格障碍（OCPD），自闭症谱系障碍（ASD），精神分裂症，精神病，癫痫，癫痫发作， 由于更年期，年龄相关性黄斑变性（AMD），早泄，男性勃起功能障碍，性功能障碍，肥胖，进食 失调，神经性贪食症，神经性厌食症，心绞痛，偏头痛，疼痛，伤害感受，睡眠障碍，失眠，纤维肌痛，酒精戒断，自闭症，Rett综合征，环状胸腺障碍，神经损伤，神经变性疾病，帕金森病，帕金森氏病精神病，亨廷顿病， 阿尔茨海默氏病，额颞叶痴呆，与年龄相关的痴呆相关的认知障碍，阿尔茨海默病，精神分裂症，精神病，抑郁症，与手术相关的疼痛或不适以及与医学疾病相关的疼痛或不适。

公开(公告)号：US20120039332A1

公开(公告)日：2012-02-16

申请号：US12855324

申请日：2010-08-12

Applicant: Steve Jackowski ,  Seth Keith ,  Daljit Singh ,  Ralph Wondra

Inventor： Steve Jackowski ,  Seth Keith ,  Daljit Singh ,  Ralph Wondra

IPC: H04L12/56

CPC classification number: H04L47/2441 ,  H04L41/0213 ,  H04L41/046 ,  H04L43/0829 ,  H04L43/0864 ,  H04L67/2819 ,  H04L69/22 ,  H04L69/32

Abstract: The present invention is directed towards systems and methods for providing multi-level classification of a network packet. In some embodiments, network performance may be enhanced and optimized by providing QoS and acceleration engines with packet- or data-specific information. In addition to source and destination IP addresses and port numbers, packet- or data-specific information can include direction of traffic (client to host or server; server or host to client; or both), Virtual LAN (VLAN) ID, source or destination application or associated application, service class, ICA priority, type of service, differentiated service code point (DSCP), or other information. Some or all of this information may be used to classify the network packet at a plurality of layers of a network stack, allowing for deep inspection of the packet and multiple levels of granularity of classification.

Abstract translation: 本发明涉及用于提供网络分组的多级分类的系统和方法。 在一些实施例中，可以通过向QoS和加速引擎提供分组或数据特定信息来增强和优化网络性能。 除了源和目标IP地址和端口号之外，数据包或数据特定信息可以包括流量方向（客户端到主机或服务器;服务器或主机到客户端;或两者），虚拟LAN（VLAN）ID，源或 目标应用程序或相关应用程序，服务类别，ICA优先级，服务类型，差异化服务代码点（DSCP）或其他信息。 这些信息中的一些或全部可以用于在网络堆栈的多个层对网络分组进行分类，允许对分组的深度检查和分级的多个级别的级别。

公开(公告)号：US06434936B1

公开(公告)日：2002-08-20

申请号：US09841603

申请日：2001-04-25

Applicant: Daljit Singh

Inventor： Daljit Singh

IPC: F02G100

CPC classification number: F02M53/04 ,  F01N5/04 ,  F02B3/06 ,  F02B33/34 ,  F02B35/02 ,  F02B39/10 ,  F02B63/04 ,  F02M61/16 ,  F02M61/166 ,  Y02T10/146 ,  Y02T10/16

Abstract: An exhaust driven turbofan to operates a generator, for generating electrical energy, which is stored in a battery until needed. An air blower is powered by energy from the battery, to generate pressurized air. The pressurized air passes into the piston chamber when the gas pedal is depressed, independent of the rotation of the crank shaft. An exhaust blower powered by the battery, sucks air from the piston chamber during the exhaust stroke, ensuring complete removal of the exhaust gasses. Valve overlap timing is no longer needed, eliminating the dwell time between intake and exhaust gasses. A non-ferrous wheel having ferrous portions is anchored in spaced relation about the outer periphery of the non-ferrous wheel, to assist the rotation of the crank shaft. At least one electromagnet is selectively energized to aid rotation of the non ferrous wheel. A diesel injector nozzle is positioned across the head of the combustion chamber for direct injection of diesel fuel as the piston power stroke approaches maximum extension. The diesel injector nozzle includes a sodium filled outer body to delay heating the fuel at the nozzle. Rotating bearings are disposed at every rotational part of the diesel engine.

Abstract translation: 一种排气驱动的涡轮风扇，用于操作发电机，用于产生电能，其被存储在电池中直到需要。 鼓风机由来自电池的能量供电，以产生加压空气。 当踏板被压下时，加压空气进入活塞室，与曲轴的旋转无关。 由电池供电的排气鼓风机在排气冲程期间从活塞室吸入空气，确保完全排出废气。 不再需要阀重叠时间，消除进气和排气之间的停留时间。 具有铁质部分的有色轮被围绕着有色金属轮的外周以相互隔开的关系固定，以帮助曲柄轴的转动。 至少一个电磁铁被选择性地通电以帮助非铁轮的旋转。 柴油喷射器喷嘴位于燃烧室的头部，用于当活塞功率冲程接近最大延伸时直接喷射柴油。 柴油喷射器喷嘴包括钠填充的外部体，以延迟在喷嘴处加热燃料。 旋转轴承设置在柴油发动机的每个旋转部分。

公开(公告)号：US4565957A

公开(公告)日：1986-01-21

申请号：US509625

申请日：1983-06-30

Applicant: James R. Gary ,  Everett R. Geis ,  Todd L. King ,  Daljit Singh

Inventor： James R. Gary ,  Everett R. Geis ,  Todd L. King ,  Daljit Singh

IPC: H02P1/46 ,  H02P1/50 ,  H02P5/40

CPC classification number: H02P1/50

Abstract: Highly reliable and consistent starting is achieved by first initializing the rotor position, namely establishing the rotor in a known starting position. This is accomplished by gating on two pairs of SCRs in sequence and supplying current pulses through the gated SCRs to the stator of the motor to rotate the rotor to a first position and then to a second position, the rotor coming to a complete stop in each of those positions. The rotor aligns itself with the magnetic field created by the stator in each position and any ambiguity in the rotor position is eliminated. Thereafter, the inverter is operated asynchronously in a second mode with predetermined pairs of the inverter SCRs being sequentially gated into conduction at an increasing frequency to current pulse energize the motor to effect step-by-step rotation of the rotor at a faster and faster rate, the motor current being reduced to zero at the termination of each energizing pulse to force commutate the conducting pair of SCRs. After the motor has reached a preset speed, operation in a third mode occurs and the inverter is synchronized with the motor, gating of the SCRs being controlled by the motor voltage in order that the rotor position will be synchronized to the revolving magnetic field created by the stator. During this third operating mode the motor speed continues to increase and the SCRs are forced commutated, as a result of which the rotor follows the stator magnetic field very closely and synchronization will be perfected. When the motor subsequently reaches a given speed sufficiently high to permit motor commutation exclusively, the starting system switches to a fourth and normal running mode wherein the gating of the inverter SCRs continues to be synchronized with the motor and controlled by the motor voltage, but the SCRs will now be commutated only by the motor voltage. Operation in the third mode provides a buffer and ensures a very smooth, reliable, consistent and a relatively short transition from asynchronous, forced-commutation operation to synchronous, motor-commutated operation.

公开(公告)号：US11634428B2

公开(公告)日：2023-04-25

申请号：US17215468

申请日：2021-03-29

Applicant: Daljit Singh Dhanoa

Inventor： Daljit Singh Dhanoa

IPC: C07D495/04 ,  C07D233/64 ,  A61K45/06 ,  C07D317/60 ,  A61K31/4706

Abstract: The present invention is concerned with novel deuterated Angiotensin-Converting Enzyme-2 (ACE-2) inhibitors of general structural formula I, their optically active enantiomers and diastereoisomers, and pharmaceutical salts and compositions thereof, as well as combination therapies which include compounds of the present invention, These compounds have high potency and selectivity for Angiotensin-Converting Enzyme-2 (ACE-2) inhibition, and are useful in the treatment of infectious respiratory diseases including the pandemic disease Covid-19, Severe Acute Respiratory Syndrome (SARS-CoV-2), Severe Acute Respiratory Syndrome (SARS-CoV), and other diseases caused by coronaviruses.

公开(公告)号：US20220306646A1

公开(公告)日：2022-09-29

申请号：US17215468

申请日：2021-03-29

Applicant: Daljit Singh Dhanoa

Inventor： Daljit Singh Dhanoa

IPC: C07D495/04 ,  C07D233/64 ,  A61K31/4706 ,  A61K45/06 ,  C07D317/60

Abstract: The present invention is concerned with novel deuterated Angiotensin-Converting Enzyme-2 (ACE-2) inhibitors of general structural formula I, their optically active enantiomers and diastereoisomers, and pharmaceutical salts and compositions thereof, as well as combination therapies which include compounds of the present invention, These compounds have high potency and selectivity for Angiotensin-Converting Enzyme-2 (ACE-2) inhibition, and are useful in the treatment of infectious respiratory diseases including the pandemic disease Covid-19, Severe Acute Respiratory Syndrome (SARS-CoV-2), Severe Acute Respiratory Syndrome (SARS-CoV), and other diseases caused by coronaviruses.

公开(公告)号：US09453027B2

公开(公告)日：2016-09-27

申请号：US14016081

申请日：2013-08-31

Applicant: Daljit Singh Dhanoa

Inventor： Daljit Singh Dhanoa

IPC: A61K31/4545 ,  C07D498/04 ,  C07D495/04 ,  C07D471/04 ,  C07D401/12 ,  A61K31/4709 ,  A61K45/06 ,  C07D513/04

CPC classification number: C07D498/04 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  C07D401/12 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention relates to deuterium-enriched pyridinonecarboxamides and their derivatives of the formula 1, and pharmaceutically acceptable salts thereof, are partial or full agonists of serotonin (5-Hydroxytryptamine or 5-HT) receptor subtype 4 (5-HT4), and are useful compounds for the prevention and treatment of Alzheimer's disease, cognitive and memory dysfunction, mild cognition impairment, memory decline, cognitive impairment associated with schizophrenia, cognitive impairment associated with age-related dementia or Alzheimer's disease, cognitive impairment associated with post-coronary bypass surgery, attention deficit hyperactivity disorder, Obsessive compulsive disorder, depression, speech improvement in autistic children, sleep apnea in Alzheimer's patients, Age-related macular degeneration (AMD), irritable bowel syndrome, gastroesophageal reflux disease, Crohn's disease, emesis, nausea, vomiting, prokinesia, non-ulcer dyspepcia, anxiety, depression, pain, migraine, urinary incontinence, arterial fibrillation, arrhythmia, ischemic stroke, gastric emptying disorders, gastritis, gastrointestinal disorders, feeding disorders, obesity, anorexia, constipation, respiratory depression, and erectile dysfunction.

公开(公告)号：US08990380B2

公开(公告)日：2015-03-24

申请号：US12855327

申请日：2010-08-12

Applicant: Steve Jackowski ,  Seth Keith ,  Daljit Singh ,  Yao Li

Inventor： Steve Jackowski ,  Seth Keith ,  Daljit Singh ,  Yao Li

IPC: G06F15/173 ,  H04L12/859 ,  H04L12/851 ,  H04L12/26

CPC classification number: H04L67/025 ,  H04L43/028 ,  H04L43/04 ,  H04L47/2433 ,  H04L47/2441 ,  H04L47/2475 ,  H04L47/2483 ,  H04L67/2819 ,  H04L67/322 ,  H04L67/42

Abstract: The present invention is directed towards systems and methods for providing discovery of applications for classification of a network packet for performing QoS and acceleration techniques. Remote display protocol traffic associated with a new application not previously included in a list of predetermined applications may be parsed for application information, and the new application may be added to the application list. The remote display protocol traffic may then be classified according to the new application, and network performance may be enhanced and optimized by providing QoS and acceleration engines with packet- or data-specific information corresponding to the newly identified application.

Abstract translation: 本发明涉及用于提供用于分类用于执行QoS和加速技术的网络分组的应用的发现的系统和方法。 与先前未包含在预定应用程序列表中的新应用相关联的远程显示协议流量可以被解析用于应用信息，并且可以将新应用添加到应用列表中。 然后可以根据新的应用对远程显示协议流量进行分类，并且可以通过向QoS和加速引擎提供与新识别的应用相对应的分组或数据特定信息来增强和优化网络性能。

公开(公告)号：US08792491B2

公开(公告)日：2014-07-29

申请号：US12855324

申请日：2010-08-12

Applicant: Steve Jackowski ,  Seth Keith ,  Daljit Singh ,  Ralph Wondra

Inventor： Steve Jackowski ,  Seth Keith ,  Daljit Singh ,  Ralph Wondra

IPC: H04L12/56

CPC classification number: H04L47/2441 ,  H04L41/0213 ,  H04L41/046 ,  H04L43/0829 ,  H04L43/0864 ,  H04L67/2819 ,  H04L69/22 ,  H04L69/32

Abstract: The present invention is directed towards systems and methods for providing multi-level classification of a network packet. In some embodiments, network performance may be enhanced and optimized by providing QoS and acceleration engines with packet- or data-specific information. In addition to source and destination IP addresses and port numbers, packet- or data-specific information can include direction of traffic (client to host or server; server or host to client; or both), Virtual LAN (VLAN) ID, source or destination application or associated application, service class, ICA priority, type of service, differentiated service code point (DSCP), or other information. Some or all of this information may be used to classify the network packet at a plurality of layers of a network stack, allowing for deep inspection of the packet and multiple levels of granularity of classification.

Abstract translation: 本发明涉及用于提供网络分组的多级分类的系统和方法。 在一些实施例中，可以通过向QoS和加速引擎提供分组或数据特定信息来增强和优化网络性能。 除了源和目标IP地址和端口号之外，数据包或数据特定信息可以包括流量方向（客户端到主机或服务器;服务器或主机到客户端;或两者），虚拟LAN（VLAN）ID，源或 目标应用程序或相关应用程序，服务类别，ICA优先级，服务类型，差异化服务代码点（DSCP）或其他信息。 这些信息中的一些或全部可以用于在网络堆栈的多个层对网络分组进行分类，允许对分组的深度检查和分级的多个级别的级别。