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公开(公告)号：US08320993B2
公开(公告)日：2012-11-27
申请号：US09805652
申请日：2001-03-13
IPC分类号： A61B5/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
摘要翻译： 这些是皮下腔标记装置和方法。 更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相，回声或其它非侵入性成像技术确定腔的中心，取向和周边。 而且，该装置包含生物可吸收或非生物可吸收标记物。 该装置可以与增强标记物或身体的不透射线，乳房摄影或回声特征的各种物质组合，从而允许通过任何非侵入性成像技术来观察。 这进一步地使用生物可吸收材料和与该材料结合的生物可吸收或非生物可吸收标记来标记皮下腔的方法。 该方法还可以组合与所述设备一起描述的任何特征。
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公开(公告)号：US08306602B2
公开(公告)日：2012-11-06
申请号：US11241500
申请日：2005-09-30
IPC分类号： A61B19/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are site marking devices for marking a selected site within tissue of a patient. More particularly, the devices include an elongated body of gel and a metallic band disposed at least partially surrounding the body of gel. The body of gel is recognizably artificial when the marker is subject to ultrasound or x-ray imaging. Therefore, it is readily distinguishable from biological features within the tissue site.
摘要翻译： 这些是用于标记患者组织内选定部位的位置标记装置。 更具体地，装置包括细长的凝胶体和至少部分地围绕凝胶体的金属带。 当标记物进行超声或X射线成像时，凝胶体是可识别的人造体。 因此，它很容易与组织部位内的生物特征区别开来。
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公开(公告)号：US5163911A
公开(公告)日：1992-11-17
申请号：US863525
申请日：1992-04-03
申请人： D. Laksen Sirimanne , Sandra L. Cutter , Zohrab S. Kemkemian , Peter D. Heijer , Paul M. Teirstein
发明人： D. Laksen Sirimanne , Sandra L. Cutter , Zohrab S. Kemkemian , Peter D. Heijer , Paul M. Teirstein
IPC分类号： A61M25/01
CPC分类号： A61M25/01
摘要： A catheter system includes a guide wire, a working catheter and a torque device for removably coupling the working catheter to the guide wire while enabling rotation of the guide wire to the working catheter. Advancement of the guide wire in a vascular system is enabled by rotating the guide wire while the working catheter is coupled thereto. A procedure for use of the catheter system includes the simultaneous insertion of the guide wire and working catheter into a vascular system and independent rotation of the guide wire for steering the guide wire, with working catheter coupled thereto, through the vascular system.
摘要翻译： 导管系统包括引导线，工作导管和扭矩装置，用于将工作导管可移动地连接到导丝，同时能够将导丝旋转到工作导管。 通过在工作导管与其连接的同时旋转导丝，能够使导丝在血管系统中的前进。 使用导管系统的过程包括将引导线和工作导管同时插入血管系统中，并且通过血管系统与导线连接的工作导管将引导线独立旋转，用于转向导丝。
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公开(公告)号：US09669113B1
公开(公告)日：2017-06-06
申请号：US09869282
申请日：1999-12-23
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00004 , A61B2017/00539 , A61B2017/00898 , A61B2090/3912 , A61B2090/3925 , A61B2090/3962 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/0409 , A61K49/222
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
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公开(公告)号：US09492570B2
公开(公告)日：2016-11-15
申请号：US12777710
申请日：2010-05-11
申请人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
发明人： D. Laksen Sirimanne , Natalie V. Fawzi , Douglas S. Sutton , Gail S. Lebovic , Stanley R. Conston , Peter M. Wilson , Anne B. Morrissey , Mary Elizabeth Bush
CPC分类号： A61K49/006 , A61B90/39 , A61B2017/00539 , A61B2090/3925 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995
摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.
摘要翻译： 公开了腔和前哨淋巴结标记装置，标记递送装置和方法。 更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。 公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。 组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。 该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。 还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置， 对患者的至少创伤和毒性。 组合物和方法可用于标记活检腔，以及标记前哨淋巴结。 标记方法还可以将所描述的特征与标记装置和递送装置组合。
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公开(公告)号：US06356782B1
公开(公告)日：2002-03-12
申请号：US09285329
申请日：1999-04-02
IPC分类号： A61B600
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
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公开(公告)号：US6136014A
公开(公告)日：2000-10-24
申请号：US145487
申请日：1998-09-01
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/28 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0266 , A61B17/29 , A61B17/32002 , A61B17/320068 , A61B17/32056 , A61B17/34 , A61B2017/00685 , A61B2017/00867 , A61B2017/32004 , A61B90/39
摘要： This is a device for percutaneous tissue sampling or excision. In particular, it uses a rotating cutter which produces a helically cut, discrete tissue mass that is removable through a comparatively much smaller access member. The tissue mass is easily reconstructed to its original form and orientation once taken from the body for further study.
摘要翻译： 这是用于经皮组织取样或切除的装置。 特别地，它使用旋转切割器，其产生可通过相对较小的进入构件移除的螺旋切割的离散组织块。 组织块容易重构成其原始形式和取向，一次取自身体进一步研究。
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公开(公告)号：US6036698A
公开(公告)日：2000-03-14
申请号：US184766
申请日：1998-11-02
申请人： Natalie V. Fawzi , D. Laksen Sirimanne , George D. Hermann , Douglas S. Sutton , Thomas A. Howell
发明人： Natalie V. Fawzi , D. Laksen Sirimanne , George D. Hermann , Douglas S. Sutton , Thomas A. Howell
CPC分类号： A61B10/0266 , A61B17/3209 , A61B2017/00287 , A61B2017/32004 , A61B2017/32006 , A61B2017/3454 , A61B2017/346 , A61B2090/3908 , A61B90/40
摘要： This is a device for percutaneous tissue sampling or excision. In particular, it uses an expandable ring cutter which produces an accurately located, discrete tissue mass that is removable through a comparatively much smaller access member. The tissue mass is easily reconstructed to its original form and orientation once taken from the body for further study.
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公开(公告)号：US08600481B2
公开(公告)日：2013-12-03
申请号：US13604158
申请日：2012-09-05
IPC分类号： A61B5/00
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.
摘要翻译： 这些是皮下腔标记装置和方法。 更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相，回声或其它非侵入性成像技术确定腔的中心，取向和周边。 而且，该装置包含生物可吸收或非生物可吸收标记物。 该装置可以与增强标记物或身体的不透射线，乳房摄影或回声特征的各种物质组合，从而允许通过任何非侵入性成像技术来观察。 这进一步地使用生物可吸收材料和与该材料结合的生物可吸收或非生物可吸收标记来标记皮下腔的方法。 该方法还可以组合与所述设备一起描述的任何特征。
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10.发明申请DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINEL LYMPH NODES 审中-公开安全定位和标记CAVITY和SENTINEL LYMPH NODES的装置和方法公开(公告)号：US20130066195A1
公开(公告)日：2013-03-14
申请号：US13604111
申请日：2012-09-05
申请人： D. Laksen SIRIMANNE , Natalie V. FAWZI , Douglas S. SUTTON , Gail S. LEBOVIC , Stanley R. CONSTON , Peter M. WISLON , Anne B. MORRISSEY , Mary Elizabeth BUSH
发明人： D. Laksen SIRIMANNE , Natalie V. FAWZI , Douglas S. SUTTON , Gail S. LEBOVIC , Stanley R. CONSTON , Peter M. WISLON , Anne B. MORRISSEY , Mary Elizabeth BUSH
CPC分类号： A61B8/481 , A61B90/39 , A61B2090/3908 , A61B2090/3987 , A61K49/006 , A61K49/222
摘要： A subcutaneous cavity marking device percutaneously implantable in breast tissue during a biopsy procedure. The marking device including at least two implantable bodies, one made from a first material and another made from a second material wherein the first and second materials are different materials and the at least two implantable bodies are adapted to be inserted into a subcutaneous cavity created by removal of tissue. The at least two implantable bodies are detectable via non-invasive techniques as tissue cavity markers and at least one of the at least two detectable bodies is an electronic chip connected to the other of the at least two implantable bodies.
摘要翻译： 皮下腔标记装置可在活组织检查过程中经皮植入乳腺组织。 所述标记装置包括至少两个可植入体，一个由第一材料制成，另一个由第二材料制成，其中所述第一和第二材料是不同的材料，并且所述至少两个可植入体适于插入由 去除组织。 所述至少两个可植入体可通过非侵入性技术检测为组织腔标记，并且所述至少两个可检测体中的至少一个是连接至所述至少两个可植入体中的另一个的电子芯片。
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