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公开(公告)号：US20240342453A1
公开(公告)日：2024-10-17
申请号：US18518280
申请日：2023-11-22
发明人： Parminder Singh , Robert Wade Worsham , Joseph C. Trautman , Danir Bayramov , Danny Lee Bowers , Andrew Richard Klemm , Steven Richard Klemm , Guohua Chen
CPC分类号： A61M37/0015 , A61K9/0021 , A61K38/29 , A61K38/385 , A61M5/3298 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , A61M2202/0007 , A61M2202/07 , A61M2202/30 , A61M2207/00
摘要： In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
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公开(公告)号：US20230277829A1
公开(公告)日：2023-09-07
申请号：US18318603
申请日：2023-05-16
发明人： Joseph C. Trautman , Douglas Joseph Scott Bourne , Anthony Le , Robert Wade Worsham , Parminder Singh
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023
摘要： An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
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公开(公告)号：US20230134250A1
公开(公告)日：2023-05-04
申请号：US18146973
申请日：2022-12-27
发明人： Danir Bayramov , Guohua Chen , Zhongli Ding , Esi Ghartey-Tagoe , Parminder Singh , Doug Bourne
摘要： Microstructure arrays and methods for using and manufacturing the arrays are described.
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公开(公告)号：US11666740B2
公开(公告)日：2023-06-06
申请号：US17185746
申请日：2021-02-25
发明人： Joseph C. Trautman , Douglas Joseph Scott Bourne , Anthony Le , Robert Wade Worsham , Parminder Singh
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023
摘要： An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
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公开(公告)号：US20240066277A1
公开(公告)日：2024-02-29
申请号：US18505007
申请日：2023-11-08
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0053
摘要： Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity.
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公开(公告)号：US11565097B2
公开(公告)日：2023-01-31
申请号：US16513613
申请日：2019-07-16
发明人： Danir Bayramov , Guohua Chen , Zhongli Ding , Esi Ghartey-Tagoe , Parminder Singh , Doug Bourne
摘要： Microstructure arrays and methods for using and manufacturing the arrays are described.
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