公开(公告)号：US20150353565A1

公开(公告)日：2015-12-10

申请号：US14762929

申请日：2014-01-17

申请人： Hao WU ,  Ronald M. KIM ,  Jian LIU ,  Shilan LIU ,  Chundao YANG ,  Shuling ZHENG ,  MERCK SHARP & DOHME CORP.

发明人： RONALD M. KIM ,  JIAN LIU ,  HAO WU ,  SHILAN LIU ,  CHUNDAO YANG ,  SHULING ZHENG

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/4985

CPC分类号： A61K45/06 ,  A61K31/4985 ,  A61K31/519 ,  C07D473/34 ,  C07D487/04 ,  C07D519/00

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

摘要翻译： 本发明提供了根据式I的Bruton的酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐。 式I或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

公开(公告)号：US20180141962A1

公开(公告)日：2018-05-24

申请号：US15564349

申请日：2016-04-04

申请人： JIAN LIU ,  JOSEPH KOZLOWSKI ,  RONALD KIM ,  XIAOLEI GAO ,  SOBHANA BABU BOGA ,  YOUNONG YU ,  HAO WU ,  SHILAN LIU ,  CHUNDAO YANG ,  MERCK SHARP & DOHME CORP.

发明人： JIAN LIU ,  JOSEPH KOZLOWSKI ,  RONALD KIM ,  XIAOLEI GAO ,  SOBHANA BABU BOGA ,  YOUNONG YU ,  HAO WU ,  SHILAN LIU ,  CHUNDAO YANG

IPC分类号： C07D519/00 ,  A61P19/02

CPC分类号： C07D519/00 ,  A61P19/02

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In Cparticular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated dis orders.

公开(公告)号：US20210403451A1

公开(公告)日：2021-12-30

申请号：US17288707

申请日：2019-10-28

申请人： Wenyuan QIAN ,  Chundao YANG ,  Zhengwei LI ,  Jian LI ,  Shuhui CHEN

发明人： Wenyuan QIAN ,  Chundao YANG ,  Zhengwei LI ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D401/14 ,  A61P35/00

摘要： A pyrimidopyrazolone derivative as a Wee1 inhibitor and use thereof in preparation of a medicament for treating Wee1-related diseases are described. In particular, the present invention relates to a compound of formula (I), an isomer or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20140206681A1

公开(公告)日：2014-07-24

申请号：US14160587

申请日：2014-01-22

申请人： RONALD M. KIM ,  Jian Liu ,  Xiaolei Gao ,  Sobhana Babu Boga ,  Deodialsingh Guiadeen ,  Joseph A. Kozlowski ,  Wensheng Yu ,  Rajan Anand ,  Younong Yu ,  Oleg B. Selyutin ,  Ying-Duo Gao ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Hongjian Wang

发明人： RONALD M. KIM ,  Jian Liu ,  Xiaolei Gao ,  Sobhana Babu Boga ,  Deodialsingh Guiadeen ,  Joseph A. Kozlowski ,  Wensheng Yu ,  Rajan Anand ,  Younong Yu ,  Oleg B. Selyutin ,  Ying-Duo Gao ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Hongjian Wang

IPC分类号： C07D471/04 ,  A61K31/4985 ,  A61K31/506 ,  C07D487/04 ,  A61K31/5383 ,  A61K31/519 ,  A61K31/5365 ,  A61K45/06 ,  C07D498/04 ,  C07D455/02

CPC分类号： C07D491/048 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61K45/06 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00 ,  Y02A50/411 ,  Y02A50/463

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

摘要翻译： 本发明提供了根据式I的Bruton's酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

公开(公告)号：US10208047B2

公开(公告)日：2019-02-19

申请号：US15538910

申请日：2015-12-17

申请人： Jian Liu ,  Joseph A. Kozlowski ,  Brian M. Andresen ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

发明人： Jian Liu ,  Joseph A. Kozlowski ,  Brian M. Andresen ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20170362242A1

公开(公告)日：2017-12-21

申请号：US15538902

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  ABDUL-BASIT ALHASSAN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  WENSHENG YU ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  ABDUL-BASIT ALHASSAN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  WENSHENG YU ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  A61P37/02 ,  C07D519/00

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

公开(公告)号：US20170342076A1

公开(公告)日：2017-11-30

申请号：US15538910

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  BRIAN M. ANDRESEN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  BRIAN M. ANDRESEN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20150353570A1

公开(公告)日：2015-12-10

申请号：US14762954

申请日：2014-01-22

申请人： Hao WU ,  Ronald M. KIM ,  Jian LIU ,  Xiaolei GAO ,  Sobhana Babu BOGA ,  Deodialsingh GUIADEEN ,  Joseph KOZLOWSKI ,  Wensheng YU ,  Rajan ANAND ,  Younong YU ,  Oleg B. Selyutin ,  Ying-Duo GAO ,  Shilan LIU ,  Chundao YANG ,  Hongjian WANG ,  MERCK SHARP & DOHME CORP.

发明人： RONALD M. KIM ,  JIAN LIU ,  XIAOLEI GAO ,  SOBHANA BABU BOGA ,  DEODIALSINGH GUIADEEN ,  JOSEPH A. KOZLOWSKI ,  WENSHENG WU ,  RAJAN ANAND ,  YOUNONG YU ,  OLEG B. SELYUTIN ,  YING-DUO GAO ,  HAO WU ,  SHILAN LIU ,  CHUNDAO YANG ,  HONGJIAN WANG

IPC分类号： C07D491/048 ,  C07D471/04 ,  A61K45/06 ,  A61K31/5383 ,  C07D455/02 ,  A61K31/5365 ,  A61K31/497 ,  C07D498/04

CPC分类号： C07D491/048 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61K45/06 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00 ,  Y02A50/411 ,  Y02A50/463

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

摘要翻译： 本发明提供了根据式I的Bruton's酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

公开(公告)号：US20140221333A1

公开(公告)日：2014-08-07

申请号：US14233478

申请日：2012-07-19

申请人： Adrianus Petrus Antonius De Man ,  Jan-Gerard Sterrenburg ,  Han C.A. Raaijmakers ,  Allard Kaptein ,  Arthura A. Oubrie ,  Johannes Bernardus Maria Rewinkel ,  Christiaan Gerardus Johannes Maria Jans ,  Jacobus C.H.M. Wijkamans ,  Tjeerd A. Barf ,  Alan B. Cooper ,  Ronald M. Kim ,  Sobhana Babu Boga ,  Hugh Y. Zhu ,  Xiaolei Gao ,  Xin Yao ,  Rajan Anand ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Abdul-Basit Alhassan ,  James Wang ,  Younong Yu ,  Jian Liu ,  Henry M. Vaccaro

发明人： Adrianus Petrus Antonius De Man ,  Jan-Gerard Sterrenburg ,  Han C.A. Raaijmakers ,  Allard Kaptein ,  Arthura A. Oubrie ,  Johannes Bernardus Maria Rewinkel ,  Christiaan Gerardus Johannes Maria Jans ,  Jacobus C.H.M. Wijkamans ,  Tjeerd A. Barf ,  Alan B. Cooper ,  Ronald M. Kim ,  Sobhana Babu Boga ,  Hugh Y. Zhu ,  Xiaolei Gao ,  Xin Yao ,  Rajan Anand ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Abdul-Basit Alhassan ,  James Wang ,  Younong Yu ,  Jian Liu ,  Henry M. Vaccaro

IPC分类号： C07D487/04 ,  C07D513/04 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/53 ,  A61K31/4985 ,  A61K31/541

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00

摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

摘要翻译： 提供根据式（I）的6-5元稠合吡啶环化合物或其药学上可接受的盐，包含这些化合物的药物组合物及其在治疗中的用途。 特别地，提供了使用元稠合的吡啶环化合物来治疗布鲁丁的酪氨酸激酶（Btk）介导的病症。