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37 条记录 (耗时 0.023 秒)

    ANTHELMINTIC AGENTS AND THEIR USE
    3.
    发明申请
    ANTHELMINTIC AGENTS AND THEIR USE 有权
    ANTHELMINIC代理及其使用

    公开(公告)号：US20120094981A1

    公开(公告)日：2012-04-19

    申请号：US13378377

    申请日：2010-06-16

    申请人： Christophe Pierre Alain Chassaing ,  Thorsten Meyer

    发明人： Christophe Pierre Alain Chassaing ,  Thorsten Meyer

    IPC分类号： A61K31/551 ,  A61K31/496 ,  A61P33/10 ,  C07D401/12 ,  A61K31/4545 ,  C07D401/04 ,  C07D417/04

    CPC分类号： C07D213/74 ,  C07D213/84 ,  C07D285/125 ,  C07D401/04 ,  C07D401/12

    摘要： This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds of this invention, pharmaceutical compositions and kits comprising the compounds of this invention, uses of the compounds of this invention to make medicaments, and treatments comprising the administration of the compounds of this invention to animals in need of the treatments.

    摘要翻译： 本发明涉及式（I）化合物及其盐，因此通常可用作驱肠剂或作为制备驱肠剂的方法中的中间体。 本发明还涉及制备本发明化合物的方法，包含本发明化合物的药物组合物和试剂盒，本发明化合物的用途制备药物，以及包括将本发明化合物施用于动物的治疗 需要治疗。

    Novel Benzimidazole(Thio)Carbamates with Antiparasitic Activity and the Synthesis Thereof
    4.
    发明申请
    Novel Benzimidazole(Thio)Carbamates with Antiparasitic Activity and the Synthesis Thereof 有权
    具有抗寄生虫活性的新型苯并咪唑（Thio）氨基甲酸酯及其合成

    公开(公告)号：US20090131369A1

    公开(公告)日：2009-05-21

    申请号：US11997057

    申请日：2006-07-18

    申请人： Christophe Pierre Alain Chassaing

    发明人： Christophe Pierre Alain Chassaing

    IPC分类号： A61K31/675 ,  C07F9/06

    CPC分类号： C07F9/65068

    摘要： This invention relates to benzimidazole carbamates and (thio)carbamates corresponding to Formula I: Here, X1 and X2 are independently O or S, wherein at least one of X1 and X2 is O; Y1 and Y2 are independently O or S, wherein at least one of Y1 and Y2 is O; R1 is alkyl having from 1-4 carbon atoms; R2, R3, and R4 are independently hydrogen or a cation; R5 and R6 are independently hydrogen, halogen, alkyl (having from 1-8 carbon atoms), —OR7, —SR8, —CO—R9, —OSO2—Ar, or —S(O)R10; R7 is alkyl having from 1-8 carbon atoms; R8 is alkyl (having from 1-8 carbon atoms) or aryl; R9 is alkyl (having from 1-8 carbon atoms), cycloalkyl (having from 3-6 carbon atoms), or aryl; Ar is aryl; and R10 is alkyl (having from 1-8 carbon atoms) or aryl. The compounds generally are soluble and stable in water, and have antiparasitic (particularly anthelmintic) activity in vivo that is comparable to known water-insoluble benzimidazole carbamates (e.g., albendazole and fenbendazole).

    摘要翻译： 本发明涉及对应于式I的苯并咪唑氨基甲酸酯和（硫代）氨基甲酸酯：这里，X 1和X 2独立地为O或S，其中X 1和X 2中的至少一个为O; Y1和Y2独立地为O或S，其中Y1和Y2中的至少一个为O; R1是具有1-4个碳原子的烷基; R2，R3和R4独立地为氢或阳离子; R5和R6独立地是氢，卤素，具有1-8个碳原子的烷基，-OR7，-SR8，-CO-R9，-OSO2-Ar或-S（O）R10; R7是具有1-8个碳原子的烷基; R8是烷基（具有1-8个碳原子）或芳基; R9是烷基（具有1-8个碳原子），环烷基（具有3-6个碳原子）或芳基; Ar为芳基; 和R 10是烷基（具有1-8个碳原子）或芳基。 化合物通常在水中是可溶的和稳定的，并且在体内具有与已知的水不溶性苯并咪唑氨基甲酸酯（例如阿苯达唑和芬苯达唑）相当的抗寄生虫（特别是驱肠虫）活性。

    Fluid dispenser
    5.
    发明授权
    Fluid dispenser 有权
    流体分配器

    公开(公告)号：US07007831B2

    公开(公告)日：2006-03-07

    申请号：US10809905

    申请日：2004-03-26

    申请人： Hervé Pennaneac'h ,  Christophe Pierre

    发明人： Hervé Pennaneac'h ,  Christophe Pierre

    IPC分类号： B05B11/16

    CPC分类号： A45D34/02 ,  A45D34/04 ,  A45D40/0087 ,  A45D2200/057 ,  B05B11/048 ,  B65D75/58 ,  B65D83/00 ,  B65D2221/00

    摘要： A fluid dispenser comprising: a fluid reservoir (12) defining at least one actuating wall (21) suitable for being displaced; a dispensing orifice (41); and spring means (7) suitable for loading the actuating wall into a state in which the volume of the reservoir is at its maximum; said fluid dispenser being characterized in that the spring means (7) co-operate with cocking means (11) suitable for bringing the spring means to a state loading the actuating wall from an initial state in which the spring means do not load the actuating wall.

    摘要翻译： 一种流体分配器，包括：限定适于被移位的至少一个致动壁（21）的流体储存器（12） 分配孔（41）; 以及适于将所述致动壁装载到所述储存器的体积处于其最大值的状态的弹簧装置（7） 所述流体分配器的特征在于，弹簧装置（7）与适于使弹簧装置处于从起动状态加载驱动壁的状态的起动装置（11）配合，在初始状态下，弹簧装置不装载致动壁 。

    Changing an operating performance point
    8.
    发明授权
    Changing an operating performance point 有权
    改变操作性能点

    公开(公告)号：US08885694B2

    公开(公告)日：2014-11-11

    申请号：US12878640

    申请日：2010-09-09

    申请人： Christophe Pierre Vatinel ,  Jerome Henri Loisel

    发明人： Christophe Pierre Vatinel ,  Jerome Henri Loisel

    IPC分类号： H04B3/46 ,  H04B17/00 ,  H04Q1/20 ,  G06F1/32

    CPC分类号： G06F1/3203 ,  G06F1/324 ,  G06F1/3296 ,  Y02D10/126 ,  Y02D10/172

    摘要： A method of changing an operating performance point of an integrated circuit including detecting a need to change the operating performance point of the integrated circuit to a new operating performance point. The method also includes changing a voltage of the integrated circuit to correspond with the new operating performance point, changing a maximal receiver clock frequency value to correspond with the new operating performance point, exporting the maximal receiver clock frequency value to a distant integrated circuit, and receiving an acknowledgement of the changed maximal receiver clock frequency value from the distant integrated circuit.

    摘要翻译： 一种改变集成电路的操作性能点的方法，包括检测需要将集成电路的操作性能点改变为新的操作性能点。 该方法还包括改变集成电路的电压以对应于新的操作性能点，改变最大接收机时钟频率值以对应于新的操作性能点，将最大接收机时钟频率值输出到远程集成电路，以及 接收来自遥控集成电路的改变的最大接收机时钟频率值的确认。

    NOVEL SPIROINDOLINE COMPOUNDS
    9.
    发明申请
    NOVEL SPIROINDOLINE COMPOUNDS 有权
    新型螺旋体化合物

    公开(公告)号：US20140163056A1

    公开(公告)日：2014-06-12

    申请号：US14236946

    申请日：2012-08-03

    申请人： Christophe Pierre Alain Chassaing ,  Sandra Koch ,  Jürgen LUTZ

    发明人： Christophe Pierre Alain Chassaing ,  Sandra Koch ,  Jürgen LUTZ

    IPC分类号： C07D471/10

    CPC分类号： C07D471/10

    摘要： This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

    摘要翻译： 本发明涉及通常可用作药物的式（I）的新型螺二氢吲哚化合物，更具体地说是作为动物的药物。 药物可优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。 本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。 本发明还涉及所述化合物的制备。 此外，本发明涉及包含该化合物的药物组合物和试剂盒。

    STOPPER MEMBER AND A DISPENSER INCLUDING SUCH A MEMBER
    10.
    发明申请
    STOPPER MEMBER AND A DISPENSER INCLUDING SUCH A MEMBER 有权
    STOPPER会员和包括这样一个会员的分配者

    公开(公告)号：US20130015213A1

    公开(公告)日：2013-01-17

    申请号：US13547915

    申请日：2012-07-12

    申请人： Fabrice PERIGNON ,  Christophe PIERRE

    发明人： Fabrice PERIGNON ,  Christophe PIERRE

    IPC分类号： B65D47/00

    CPC分类号： B65D75/5883 ,  B65D2221/00 ,  Y10S383/906

    摘要： A stopper for being sealed between two sheets of a reservoir, including a body defining a front face, rear face, internal edge, and external edge. The body forms a dispenser orifice that passes through from the rear face to the front face, the front and rear faces defining front and rear heat-sealing zones for the sheets. The front face defines a fluid collection zone at the orifice and the rear face defines a fluid delivery channel that extends from the dispenser orifice to the internal edge of the body. A closure lid is provided, the lid connected to the base body via a hinge. The body defines tapering side edges where the front and rear heat-sealing zones are contiguous, and the front and rear faces are convex, to define a maximum thickness where the dispenser orifice, the delivery channel, and a fraction of the collection zone are formed.

    摘要翻译： 用于密封在两片储存器之间的止动件，包括限定前表面，后表面，内边缘和外边缘的主体。 主体形成从后表面到前表面通过的分配器孔口，前表面和后表面限定片材的前后热封区域。 前表面在孔处限定了流体收集区，并且后表面限定了从分配器孔延伸到身体的内部边缘的流体输送通道。 提供封闭盖，盖子通过铰链连接到基体上。 主体限定锥形侧边缘，其中前后热封区域邻接，并且前表面和后表面是凸形的，以限定分配器孔口，输送通道和收集区域的一部分形成的最大厚度 。