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1.发明申请公开(公告)号：US20070031827A1
公开(公告)日：2007-02-08
申请号：US11520354
申请日：2006-09-12
Applicant: Ching-Yu Lin , Ruey-Wen Lin , Chiou-Mien You , Hsing-Hsuan Huang , Bor-Heng Lee , Hsien-Hsiung Lee , Yu-Ju Lin , Chih-Chun Fan , Han-Chuan Hsu , Chia-Wen Shih , Chih-Hsing Yeh , Yi-Feng Kao , Chih-Long Pan , Peter Chan
Inventor： Ching-Yu Lin , Ruey-Wen Lin , Chiou-Mien You , Hsing-Hsuan Huang , Bor-Heng Lee , Hsien-Hsiung Lee , Yu-Ju Lin , Chih-Chun Fan , Han-Chuan Hsu , Chia-Wen Shih , Chih-Hsing Yeh , Yi-Feng Kao , Chih-Long Pan , Peter Chan
CPC classification number: C12Q1/708 , C12Q2565/501
Abstract: A detector for detecting and simultaneously diagnosing at least one subtype of human papilloma viruses (HPV) contained in a biological sample is provided. The detector comprises: a carrier, a plurality of micro-dots immobilized on the carrier, wherein each micro-dot is for identifying one particular HPV subtype, and the HPV subtype is one selected from a group consisting of 39 different HPV subtypes; and at least one oligonucleotide sequence contained in each the micro-dot that is specific to the one particular HPV subtype, wherein the at least one oligonucleotide sequence serves as a detection probe that hybridizes specifically with an L1 gene sequence of the one particular HPV subtype to form a hybridization complex as a detection indicator, so that each micro-dot identifies one particular HPV subtype via a corresponding oligonucleotide of the one particular HPV subtype, and thereby detecting and simultaneously identifying subtypes of human papilloma viruses.
Abstract translation: 提供了用于检测并同时诊断生物样品中包含的至少一种人乳头瘤病毒（HPV）亚型的检测器。 检测器包括：载体，固定在载体上的多个微点，其中每个微点用于鉴定一个特定的HPV亚型，并且HPV亚型是从39个不同的HPV亚型组成的组中选择的一个; 以及至少一个寡核苷酸序列，其特征在于每个特定HPV亚型的微点中包含的寡核苷酸序列，其中所述至少一个寡核苷酸序列用作与所述特定HPV亚型的L1基因序列特异性杂交的检测探针， 形成杂交复合物作为检测指标，使得每个微点通过一个特定HPV亚型的相应寡核苷酸识别一个特定的HPV亚型，从而检测并同时鉴定人乳头状瘤病毒的亚型。
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2.发明申请公开(公告)号：US20050175989A1
公开(公告)日：2005-08-11
申请号：US10601497
申请日：2003-06-23
Applicant: Ching-Yu Lin , Ruey-Wen Lin , Chiou-Mien You , Chiu-Cho Yan , Bor-Heng Lee , Hsien-Hsiung Lee , Yu-Ju Lin , Chih-Chun Fan , Han-Chuan Hsu , Chia-Wen Shih , Chih-Hsing Yeh , Yi-Feng Kao , Chih-Long Pan , Yen-Ming Lin , Peter Chan
Inventor： Ching-Yu Lin , Ruey-Wen Lin , Chiou-Mien You , Chiu-Cho Yan , Bor-Heng Lee , Hsien-Hsiung Lee , Yu-Ju Lin , Chih-Chun Fan , Han-Chuan Hsu , Chia-Wen Shih , Chih-Hsing Yeh , Yi-Feng Kao , Chih-Long Pan , Yen-Ming Lin , Peter Chan
CPC classification number: C12Q1/708 , C12Q2565/501
Abstract: A detector for detecting and simultaneously diagnosing at least one subtype of human papilloma viruses (HPV) contained in a biological sample is provided. The detector comprises: a carrier, a plurality of micro-dots immobilized on the carrier, wherein each micro-dot is for identifying one particular HPV subtype, and the HPV subtype is one selected from a group consisting of 39 different HPV subtypes; and at least one oligonucleotide sequence contained in each the micro-dot that is specific to the one particular HPV subtype, wherein the at least one oligonucleotide sequence serves as a detection probe that hybridizes specifically with an L1 gene sequence of the one particular HPV subtype to form a hybridization complex as a detection indicator, so that each micro-dot identifies one particular HPV subtype via a corresponding oligonucleotide of the one particular HPV subtype, and thereby detecting and simultaneously identifying subtypes of human papilloma viruses.
Abstract translation: 提供了用于检测并同时诊断生物样品中包含的至少一种人乳头瘤病毒（HPV）亚型的检测器。 检测器包括：载体，固定在载体上的多个微点，其中每个微点用于鉴定一个特定的HPV亚型，并且HPV亚型是从39个不同的HPV亚型组成的组中选择的一个; 以及至少一个寡核苷酸序列，其特征在于每个特定HPV亚型的微点中包含的寡核苷酸序列，其中所述至少一个寡核苷酸序列用作与所述特定HPV亚型的L1基因序列特异性杂交的检测探针， 形成杂交复合物作为检测指标，使得每个微点通过一个特定HPV亚型的相应寡核苷酸识别一个特定的HPV亚型，从而检测并同时鉴定人乳头状瘤病毒的亚型。
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