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公开(公告)号：US09102627B2
公开(公告)日：2015-08-11
申请号：US13619788
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , C07D223/16 , C07D401/02 , C07D403/02 , C07C209/50 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C17/16 , C07C25/06 , C07C209/74 , C07C211/27
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译： 本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。
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2.发明授权Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases 失效苯扎西平衍生物和预防或治疗5ht2c受体相关疾病的方法公开(公告)号：US07704993B2
公开(公告)日：2010-04-27
申请号：US10561071
申请日：2004-06-16
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。
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公开(公告)号：US08946207B2
公开(公告)日：2015-02-03
申请号：US13619773
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , C07D223/16 , C07C209/50 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C17/16 , C07C25/06 , C07C209/74 , C07C211/27
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
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公开(公告)号：US20130178620A1
公开(公告)日：2013-07-11
申请号：US13619773
申请日：2012-09-14
申请人： Beverly L. Wolgast , CHARLES A. GILSON, III , SHELLEY AYTES , SCOTT A. ESTRADA , DIPANJAN SENGUPTA , BRIAN SMITH , MAX REY , ULRICH WEIGL , HEIDEDORE JLSABETH REY-PAPINA
发明人： Beverly L. Wolgast , CHARLES A. GILSON, III , SHELLEY AYTES , SCOTT A. ESTRADA , DIPANJAN SENGUPTA , BRIAN SMITH , MAX REY , ULRICH WEIGL
IPC分类号： C07D223/16 , C07C17/16 , C07C211/27 , C07C213/02 , C07C209/74 , C07C215/08 , C07C25/06
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译： 本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。
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5.发明授权Benzazepine derivatives and methods of prophylaxis or treatment of 5HT2C receptor associated diseases 失效苯扎西平衍生物和预防或治疗5HT2C受体相关疾病的方法公开(公告)号：US08404675B2
公开(公告)日：2013-03-26
申请号：US12729026
申请日：2010-03-22
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。
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公开(公告)号：US08367657B2
公开(公告)日：2013-02-05
申请号：US10560953
申请日：2004-06-16
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61P25/00 , A61K31/55 , C07D223/00
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
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7.发明申请BENZAZEPINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES 失效苯并噻吩衍生物和5HT2C受体相关疾病预防或治疗方法公开(公告)号：US20100173894A1
公开(公告)日：2010-07-08
申请号：US12729026
申请日：2010-03-22
IPC分类号： A61K31/55 , C07D223/16 , A61P3/04 , A61P3/10 , A61P25/28 , A61P25/18 , A61P9/00 , A61P25/24 , A61P25/22 , A61P25/20 , A61P25/00
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。
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8.发明申请Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases 审中-公开苯扎氮平衍生物和预防或治疗5Ht2c受体相关疾病的方法公开(公告)号：US20080009478A1
公开(公告)日：2008-01-10
申请号：US10576849
申请日：2004-10-21
IPC分类号： A61K31/55 , A61P15/00 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P3/04 , C07D223/16
CPC分类号： C07D223/16
摘要： The present invention relates to substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及作为5HT 2C受体的调节剂的取代-2,3,4,5-四氢-3-苯并氮杂衍生物。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，例如肥胖症和相关疾病。
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公开(公告)号：US20130165648A1
公开(公告)日：2013-06-27
申请号：US13619788
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
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10.发明申请BENZAZEPINE DERIVATIVES USEFUL FOR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES 审中-公开用于治疗5HT2C受体相关疾病的苯扎林衍生物公开(公告)号：US20130172322A1
公开(公告)日：2013-07-04
申请号：US13616784
申请日：2012-09-14
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译： 本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。 因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。
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