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    Bath Genie
    2.
    发明申请
    Bath Genie 审中-公开
    浴精灵

    公开(公告)号：US20090116894A1

    公开(公告)日：2009-05-07

    申请号：US11982227

    申请日：2007-11-02

    申请人： Catherine Smith Brantley ,  Patricia Ann Zamadie

    发明人： Catherine Smith Brantley ,  Patricia Ann Zamadie

    IPC分类号： A47K7/02

    CPC分类号： A47K7/03

    摘要： A multi-use washcloth made for retaining a bar of soap or shower gel for use in the bath or shower and assist the user from dropping the soap bar and wastage of the soap. Furthermore it can be used as an ice pack, and cosmetic bag. The washcloth is fabricated from soft porous and flexible cut into predetermined lengths and widths and stitched together on three sides and open fourth end forming a simple bag. At the opening of the bag a hook-and-loop fasteners are stitched to the two sides of the open ends. Hence it helps to retain the products (such as soap bar, shower gel, ice and cosmetics) whenever the wash cloth is being used in the various ways.

    摘要翻译： 一种多用途的毛巾，用于保留一根皂或沐浴露，用于洗浴或淋浴，并帮助使用者放下肥皂条和浪费肥皂。 此外，它可以用作冰袋和化妆包。 毛巾由柔软的多孔和柔性切割制成预定的长度和宽度，并在三面缝合在一起并且打开第四端形成简单的袋子。 在袋的开口处，钩环紧固件被缝合到开口端的两侧。 因此，每当洗涤布以各种方式使用时，它有助于保留产品（如肥皂条，沐浴露，冰和化妆品）。

    Methods of amination
    3.
    发明申请
    Methods of amination 失效
    胺化方法

    公开(公告)号：US20070179315A1

    公开(公告)日：2007-08-02

    申请号：US10593212

    申请日：2005-03-18

    申请人： Andrew Holmes ,  Catherine Smith ,  Melanie Tsang ,  Theresa Early ,  Richard Shute

    发明人： Andrew Holmes ,  Catherine Smith ,  Melanie Tsang ,  Theresa Early ,  Richard Shute

    IPC分类号： C07C209/00

    CPC分类号： C07C227/08 ,  C07C209/10 ,  C07C213/02 ,  C07D207/325 ,  C07D207/327 ,  C07C211/55 ,  C07C217/92 ,  C07C229/60

    摘要： A method of synthesizing a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is a labile leaving group; RN1 is optionally substituted C5-20 aryl; RN2 is selected from optionally substituted C5-20aryl, optionally substituted C3-20 heterocyclyl, optionally substituted C3-7 alkyl, and optionally substituted sulfonyl; RN3 is selected from H and optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl; or RN2 and RN3 together with the nitrogen atom to which they are attached form optionally substituted nitrogen-containing C3-20 heterocylyl or C5-20 heteroaryl; and R1 R2 and R3 are independently selected from optionally substituted C1-7 alkyl, C5-20 aryl, C3-20 heterocyclyl, hydroxy, halo, amino and C1-7 alkoxy, or two of R1, R2 and R3, together with the silicon atom to which they are attached, may form a silicon containing C5-7 heterocyclyl group.

    摘要翻译： 合成式I化合物的方法：包括使式II部分与式III部分反应的步骤：在过渡金属催化剂和碱的存在下，在压缩二氧化碳中，其中L是不稳定的离去 组; R 01是任选取代的C 5-20芳基; R N2选自任选取代的C 5-20芳基，任选取代的C 3-20杂环基，任选取代的C 3-8芳基， 7烷基和任选取代的磺酰基; R N 3选自H和任选取代的C 1-7 - 烷基，C 3-20 - 杂环基和C 5-20杂环基， / SUB>芳基; 或R N2和R N3与它们所连接的氮原子一起形成任选取代的含氮C 3-20异氰酸酯或C 5-20杂芳基; R 1和R 3独立地选自任选取代的C 1-7烷基，C 1 -C 6烷基， 羟基，卤素，氨基和C 1-7 - 烷氧基，或者R 1，R 2，R 2， 1，R 2和R 3与它们所连接的硅原子一起可以形成含有C 5-7的硅， / SO 2杂环基。

    Methods of diagnosing tissue fibrosis
    9.
    发明申请
    Methods of diagnosing tissue fibrosis 有权
    诊断组织纤维化的方法

    公开(公告)号：US20050186561A1

    公开(公告)日：2005-08-25

    申请号：US10971195

    申请日：2004-10-22

    申请人： Esther Oh ,  Catherine Smith

    发明人： Esther Oh ,  Catherine Smith

    IPC分类号： A61B20060101 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/52

    摘要： The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of α2-MG, HA and TIMP-1.

    摘要翻译： 本发明提供一种通过检测来自个体的样品中的α2-巨球蛋白（α2-MG）来诊断个体中组织纤维化的存在或严重性的方法; 检测来自个体的样品中的透明质酸（HA）; 检测来自个体的样品中金属蛋白酶-1（TIMP-1）的组织抑制剂; 并基于α2-MG，HA和TIMP-1的存在或水平诊断个体中组织纤维化的存在或严重程度。