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公开(公告)号：US20100233173A1
公开(公告)日：2010-09-16
申请号：US12717978
申请日：2010-03-05
申请人： Herren WU , Changshou GAO , Carl HAY , Nazzareno DIMASI
发明人： Herren WU , Changshou GAO , Carl HAY , Nazzareno DIMASI
CPC分类号： C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/622 , C07K2317/64
摘要： The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases.
摘要翻译： 本发明涉及多特异性表位结合蛋白，其制备方法及其在预防，治疗，诊断或诊断急性或慢性疾病中的用途。
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2.发明授权公开(公告)号：US08039606B2
公开(公告)日：2011-10-18
申请号：US12576296
申请日：2009-10-09
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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3.发明申请公开(公告)号：US20060159659A1
公开(公告)日：2006-07-20
申请号：US11335891
申请日：2006-01-19
申请人： Paul Hallenbeck , Seshidar Police , Laura Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidar Police , Laura Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： A61K48/00 , C07H21/04 , C12N7/00 , C12N15/86 , C07K14/085
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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公开(公告)号：US20070275915A1
公开(公告)日：2007-11-29
申请号：US10553386
申请日：2004-04-15
申请人： Paul Hallenbeck , Garret Hampton , Carl Hay , Ying Huang , John Jakubczak
发明人： Paul Hallenbeck , Garret Hampton , Carl Hay , Ying Huang , John Jakubczak
IPC分类号： A61K31/7088 , A61P35/00 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C07K14/4702 , C12N15/85 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , C12N2840/007
摘要： The present invention generally relates to substances and methods useful for the treatment of neoplastic disease. More specifically, it relates to cancer selective promoters and their use in oncolytic adenoviral vectors. The oncolytic adenoviral vectors are useful in methods of gene therapy. The promoters and the oncolytic adenoviral vectors are useful in methods for screening for compounds that modulate the expression of the cancer selective genes.
摘要翻译： 本发明一般涉及可用于治疗肿瘤性疾病的物质和方法。 更具体地，涉及癌症选择性启动子及其在溶瘤腺病毒载体中的应用。 溶瘤腺病毒载体可用于基因治疗的方法。 启动子和溶瘤腺病毒载体可用于筛选调节癌症选择性基因表达的化合物的方法。
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公开(公告)号：US20070212675A1
公开(公告)日：2007-09-13
申请号：US10553459
申请日：2004-04-15
申请人： Paul Hallenbeck , Garret Hampton , Carl Hay , Ying Huang , John Jakubczak , Sandrina Phipps
发明人： Paul Hallenbeck , Garret Hampton , Carl Hay , Ying Huang , John Jakubczak , Sandrina Phipps
IPC分类号： C12Q1/00
CPC分类号： C12N9/22
摘要： FEN1 transcriptional regulatory sequences (TREs) are provided. FEN1 TREs provide for transcriptional regulation dependent upon transcription factors that are only active in cancer cells. The FEN1 TREs may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for selective expression in cancer cells.
摘要翻译： 提供FEN1转录调控序列（TRE）。 FEN1 TRE提供依赖于仅在癌细胞中活跃的转录因子的转录调节。 FEN1 TRE可以用作引入新的遗传能力，特别是与细胞毒性有关的载体，用于在癌细胞中的选择性表达。
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6.发明授权公开(公告)号：US08753622B2
公开(公告)日：2014-06-17
申请号：US13209124
申请日：2011-08-12
申请人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
发明人： Paul Hallenbeck , Seshidhar Reddy Police , Laura M. Hales , Carl Hay , Shanthi Ganesh , Ling Xu , Jingping Yang , Cheng Cheng
IPC分类号： A61K35/76 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： A61K35/768 , A61K39/00 , A61K2039/525 , C07K14/005 , C07K16/1009 , C12N7/00 , C12N2770/32021 , C12N2770/32022 , C12N2770/32032 , C12N2770/32033 , C12N2770/32061 , G01N33/5011 , G01N2333/085
摘要： The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
摘要翻译： 本发明涉及一种称为塞尼卡谷病毒（“SVV”）的新型小RNA病毒RNA。 本发明提供了由这些核酸编码的分离的SVV核酸和蛋白质。 此外，本发明提供针对SVV蛋白产生的抗体。 由于SVV具有选择性地杀死一些类型的肿瘤的能力，本发明提供了使用SVV和SVV多肽治疗癌症的方法。 由于SVV特异性靶向某些肿瘤，本发明提供了使用SVV核酸和蛋白质来检测癌症的方法。 另外，由于SVV的肿瘤特异性机制提供的信息，本发明提供了制备新的溶瘤病毒衍生物和改变病毒以具有肿瘤特异性嗜性的方法。
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公开(公告)号：US20090155275A1
公开(公告)日：2009-06-18
申请号：US12182975
申请日：2008-07-30
申请人： Herren WU , Changshou GAO , Carl HAY , Nazzareno DIMASI
发明人： Herren WU , Changshou GAO , Carl HAY , Nazzareno DIMASI
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/622 , C07K2317/64
摘要： The present invention relates to multispecific epitope binding proteins, methods of making, and uses thereof in the prevention, management, treatment or diagnosis of acute or chronic diseases.
摘要翻译： 本发明涉及多特异性表位结合蛋白，其制备方法及其在预防，治疗，诊断或诊断急性或慢性疾病中的用途。
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