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公开(公告)号：US20100179213A1
公开(公告)日：2010-07-15
申请号：US12616616
申请日：2009-11-11
申请人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
发明人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
IPC分类号： A61K31/7088 , A61P35/04 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2310/141
摘要： The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells.
摘要翻译： 本发明涉及通过靶向癌症干细胞来治疗患有怀疑具有或具有发展癌症风险的患者的方法和组合物。
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公开(公告)号：US10202604B2
公开(公告)日：2019-02-12
申请号：US15606638
申请日：2017-05-26
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
摘要： Provided herein are methods of treating a cancer in an individual. A microRNA-141 oligonucleotide or mimic that increases the expression of microRNA-141 in the cancer cell is administered to the individual. Also provided is a method of inhibiting proliferation of a cancer cell and treating a cell associated with a cancer. The cell is contacted with the microRNA-141 oligonucleotide or mimic.
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公开(公告)号：US20170342417A1
公开(公告)日：2017-11-30
申请号：US15606638
申请日：2017-05-26
IPC分类号： C12N15/113
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/141
摘要： Provided herein are methods of treating a cancer in an individual. A microRNA-141 oligonucleotide or mimic that increases the expression of microRNA-141 in the cancer cell is administered to the individual. Also provided is a method of inhibiting proliferation of a cancer cell and treating a cell associated with a cancer. The cell is contacted with the microRNA-141 oligonucleotide or mimic.
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