公开(公告)号：US20230073245A1

公开(公告)日：2023-03-09

申请号：US17758264

申请日：2021-01-13

Applicant: The University of Chicago ,  Central Michigan University

Inventor： Aaron ESSER-KAHN ,  Saikat MANNA ,  WenJun DU ,  Sampa MAITI

IPC: A61K9/51 ,  A61K47/69

Abstract: Aspects of the disclosure relate to nanoparticle formulations and methods for generating nanoparticles. Embodiments include nanoparticles comprising an amphiphile and a polymer co-assembly agent. In some cases, polymers for use in therapeutic delivery are described. In some embodiments, the disclosed methods and compositions involve TLR agonists and formulations thereof capable of activating an immune response. Certain aspects relate to nanoparticles comprising linked TLR agonists for use in immunotherapy.

公开(公告)号：US20210261591A1

公开(公告)日：2021-08-26

申请号：US17306701

申请日：2021-05-03

Applicant: Central Michigan University

Inventor： Benjamin M. Swarts

IPC: C07H7/06 ,  G01N33/60 ,  C12Q1/16 ,  G01N33/58 ,  C12Q1/04

Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.

公开(公告)号：US10995110B2

公开(公告)日：2021-05-04

申请号：US16714017

申请日：2019-12-13

Applicant: Central Michigan University

Inventor： Benjamin M. Swarts

IPC: C07H7/06 ,  G01N33/60 ,  C12Q1/16 ,  G01N33/58 ,  C12Q1/04

Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.

公开(公告)号：US20180316172A1

公开(公告)日：2018-11-01

申请号：US15911823

申请日：2018-03-05

Applicant: Central Michigan University

Inventor： Oumar Rafiou Barry ,  Emadeddin Y. Tanbour ,  Nitish Kumar Vaja ,  Hesham Tanbour

IPC: H02G7/14 ,  H02G7/05

CPC classification number: H02G7/14 ,  H02G7/053

Abstract: An asymmetric Stockbridge damper having at least six and as many as ten resonant frequencies. The damper includes two assemblies, each having a primary weight at the end of a messenger cable and two secondary weights at the ends of thin beams. The thin beams are mounted at one end to the primary weight and each support a secondary weight at an opposite end. The thin beams extend parallel to the messenger cable. The messenger cable is affixed to a clamp assembly which clamps to an overhead transmission line. The clamp assembly includes a toggle crank generating a theoretically infinite clamping force on the transmission line.

公开(公告)号：US20160171322A1

公开(公告)日：2016-06-16

申请号：US15052211

申请日：2016-02-24

Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA ,  CENTRAL MICHIGAN UNIVERSITY

Inventor： Pujitha GUNARATNE ,  Richard W. BACKS

IPC: G06K9/00 ,  B60K28/06

CPC classification number: G06K9/00845 ,  A61B3/113 ,  A61B5/1103 ,  A61B5/1128 ,  A61B5/18 ,  A61B5/6893 ,  B60K28/066 ,  G06K9/00604 ,  G08B21/0476 ,  G08G1/165 ,  G08G1/166 ,  Y02T10/84

Abstract: A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency.

Abstract translation: 一种用于确定车辆操作者的不注意状态并通过获得车辆的操作者的脸部图像来提供信息给车辆的操作者的方法和装置，获得车辆的环境的图像，确定一个或多个区域 基于环境的图像对车辆的环境感兴趣，从相关性和优先级数据库获得与一个或多个感兴趣区域对应的相关性和优先级值，确定车辆操作者的注意概率 基于环境的图像和相关性和优先级值到一个或多个感兴趣的区域，基于确定的注意的概率和面部图像来确定注意力不足，并且基于以下方式向车辆的操作者提供信息： 确定的注意力缺陷。

公开(公告)号：US20150023857A1

公开(公告)日：2015-01-22

申请号：US14331792

申请日：2014-07-15

Applicant: Massachusetts Institute of Technology ,  Central Michigan University ,  Robert Bosch LLC Research and Techology Center

Inventor： Rickard Roberto ARMIENTO ,  Gerbrand CEDER ,  Marco FORNARI ,  Geoffroy HAUTIER ,  Boris KOZINSKY

IPC: H01L41/187 ,  G06F19/00

CPC classification number: H01L41/1878 ,  C04B35/01 ,  C04B35/457 ,  C04B35/462 ,  C04B35/4682 ,  C04B35/47 ,  C04B35/49 ,  C04B35/495 ,  C04B2235/3201 ,  C04B2235/3203 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3217 ,  C04B2235/3224 ,  C04B2235/3232 ,  C04B2235/3244 ,  C04B2235/3251 ,  C04B2235/3281 ,  C04B2235/3286 ,  C04B2235/3293 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/72 ,  C04B2235/768 ,  G16C99/00 ,  H01L41/1871 ,  H01L41/1873

Abstract: One embodiment provides a method, comprising: calculating, using at least one computer, a distance to a hull for an alloy XxY1-x in the range 0.01≦x≦0.99, where X and Y are perovskite materials; determining, using the at least one computer, a preferred phase for the alloy in the range 0.01≦x≦0.99; and selecting an alloy composition having the distance to the hull being less than 0.1 eV/atom and for which the preferred phase in at least a portion of the range 0.01≦x≦0.99 is a tetragonal phase. Piezoelectric materials as selected by the method are also provided.

Abstract translation: 一个实施方案提供了一种方法，其包括：使用至少一台计算机计算在0.01和nlE; x＆lt; lE; 0.99范围内合金X x Y 1-x的船体距离，其中X和Y是钙钛矿材料; 使用所述至少一台计算机确定所述合金在0.01≤n≤E≤0.99的范围内的优选相; 并且选择具有与船体的距离小于0.1eV /原子的合金组合物，并且其范围为0.01＆amp; NlE; x＆lt; lE; 0.99中的至少一部分中的优选相是四方晶相。 还提供了通过该方法选择的压电材料。

公开(公告)号：US20210108247A1

公开(公告)日：2021-04-15

申请号：US17124740

申请日：2020-12-17

Applicant: Central Michigan University ,  University of Maine System

Inventor： Benjamin M. Swarts ,  Peter Woodruff

IPC: C12Q1/04 ,  C07H1/00 ,  C07H3/04 ,  C12P19/12

Abstract: The present invention provides methods of synthesizing trehalose analogues; methods of detecting mycobacteria, and trehalose analogues.

公开(公告)号：US20180044397A1

公开(公告)日：2018-02-15

申请号：US15545428

申请日：2016-01-22

Applicant: Brown University ,  Central Michigan University

Inventor： Christopher I. MOORE ,  Ute HOCHGESCHWENDER ,  Diane LIPSCOMBE

IPC: C07K14/705 ,  A61N5/06 ,  A01K67/027

CPC classification number: C07K14/705 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0393 ,  A61N5/062 ,  C07K2319/60 ,  C12N2750/14141

Abstract: The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of the invention can be used to desynchronize local activity of excitable cells in a mammalian tissue. The methods of the invention can be used to treat a disease or condition in a mammal, the disease or condition being related to bursting. The disease or condition can be Parkinson's disease, epilepsy, a sleep disorder, or a sensory-related disease or condition (e.g., attention deficit disorder or pain). The invention also provides a conjugate of containing a voltage-gated ion channel and a luminescent protein.

公开(公告)号：US09824286B2

公开(公告)日：2017-11-21

申请号：US15052211

申请日：2016-02-24

Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA ,  CENTRAL MICHIGAN UNIVERSITY

Inventor： Pujitha Gunaratne ,  Richard W. Backs

IPC: G08B23/00 ,  G06K9/00 ,  A61B5/18 ,  B60K28/06 ,  G08B21/04 ,  A61B5/00 ,  A61B3/113 ,  A61B5/11 ,  G08G1/16

CPC classification number: G06K9/00845 ,  A61B3/113 ,  A61B5/1103 ,  A61B5/1128 ,  A61B5/18 ,  A61B5/6893 ,  B60K28/066 ,  G06K9/00604 ,  G08B21/0476 ,  G08G1/165 ,  G08G1/166 ,  Y02T10/84

Abstract: A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency.

公开(公告)号：US20170258334A1

公开(公告)日：2017-09-14

申请号：US15455476

申请日：2017-03-10

Applicant: Central Michigan University

Inventor： Kevin C. Miller ,  Rene R. Shingles

IPC: A61B5/01 ,  A61F7/00 ,  A61B5/00

CPC classification number: A61B5/01 ,  A61B5/0008 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/6867 ,  A61B5/687 ,  A61B5/7282 ,  A61B5/746 ,  A61B5/7475 ,  A61B2503/10 ,  A61F7/0053 ,  A61F7/10 ,  A61F2007/0096

Abstract: Systems and methods are described for detecting heat stroke and monitoring cooling treatment of heat stroke. The system includes a rectal temperature probe including a flexible length and an indicator positioned on the flexible length to indicate when the probe has been inserted to a target insertion depth. A controller is configured to receive a signal from the probe indicative of a sensed temperature and to determine whether heat stroke is likely based on the sensed temperature. When monitoring cooling treatment, a cooling rate is calculated based on periodically sensed temperatures and, based on the calculated cooling rate, the system indicates whether the heat stroke is being adequately treated or if the current treatment methods are insufficient.