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    Imiquimod cocrystals
    1.
    发明授权
    Imiquimod cocrystals 有权

    公开(公告)号：US11976065B2

    公开(公告)日：2024-05-07

    申请号：US18002221

    申请日：2021-06-23

    申请人： CELISTA PHARMACEUTICALS LLC

    发明人： Yogesh Dandiker

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to novel crystalline forms of imiquimod formed with ferulic acid, acetic acid, coumaric acid, citric acid, or tartaric acid, to methods of making these cocrystals, and to compositions containing the cocrystals.

    IMIQUIMOD COCRYSTALS
    3.
    发明公开
    IMIQUIMOD COCRYSTALS 审中-公开

    公开(公告)号：US20230227448A1

    公开(公告)日：2023-07-20

    申请号：US18002221

    申请日：2021-06-23

    申请人： CELISTA PHARMACEUTICALS LLC

    发明人： Yogesh DANDIKER

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to novel crystalline forms of imiquimod formed with ferulic acid, acetic acid, coumaric acid, citric acid, or tartaric acid, to methods of making these cocrystals, and to compositions containing the cocrystals.

    SPRAYABLE LIQUID SPIRONOLACTONE COMPOSITIONS
    5.
    发明公开
    SPRAYABLE LIQUID SPIRONOLACTONE COMPOSITIONS 审中-公开

    公开(公告)号：US20240325350A1

    公开(公告)日：2024-10-03

    申请号：US18619890

    申请日：2024-03-28

    申请人： CELISTA PHARMACEUTICALS LLC

    发明人： Yogesh DANDIKER

    IPC分类号： A61K31/365 ,  A61K9/70 ,  A61K31/455 ,  A61K47/10 ,  A61K47/36

    CPC分类号： A61K31/365 ,  A61K9/7015 ,  A61K31/455 ,  A61K47/10 ,  A61K47/36

    摘要： The present disclosure provides a sprayable liquid composition comprising about 1% w/v to about 20% w/v spironolactone or canrenone, about 30% w/v to about 97% w/v aliphatic solvent, about 1% w/v to about 10% w/v water, one or more film forming excipients, wherein the film forming excipient has a solubility in water at a pH between 1 and 10, and a penetration enhancer, wherein the composition forms a washable and/or a peelable film when sprayed on a skin surface, and wherein the spironolactone does not crystallize when the composition is applied to the skin surface. The disclosure also provides a method of treating acne, male and female pattern hair loss, hirsutism, hidradenitis suppurativa, polycystic ovary syndrome (PCOS), or combinations thereof in a subject in need thereof, the method comprising topically applying the composition described herein as a spray to a skin surface of the subject.

    TOPICAL OXYBUTYNIN FOR HOT FLASHES
    6.
    发明公开
    TOPICAL OXYBUTYNIN FOR HOT FLASHES 审中-公开

    公开(公告)号：US20240148640A1

    公开(公告)日：2024-05-09

    申请号：US18502863

    申请日：2023-11-06

    申请人： CELISTA PHARMACEUTICALS LLC

    发明人： Yogesh DANDIKER

    IPC分类号： A61K9/00 ,  A61K31/222 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32

    CPC分类号： A61K9/0014 ,  A61K31/222 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32

    摘要： The present disclosure provides a sprayable composition comprising about 1% w/v to about 20% w/v of oxybutynin, a penetration enhancer, at least 65% w/v of an aliphatic solvent, and a film forming excipient, wherein the film forming excipient has a solubility in water, at a pH between 1 and 10 and wherein the composition is a sprayable liquid solution that forms a protective and washable film when sprayed on skin The disclosure also provides a method of treating vasomotor symptoms, hot flashes, hyperhidrosis, osmiodrosis, incontinence, bladder spasms, pain following bladder surgery, or combinations thereof in a subject in need thereof, the method comprising topically administering to the subject the topical compositions as described herein.