The present disclosure provides a sprayable liquid composition comprising about 1% w/v to about 20% w/v spironolactone or canrenone, about 30% w/v to about 97% w/v aliphatic solvent, about 1% w/v to about 10% w/v water, one or more film forming excipients, wherein the film forming excipient has a solubility in water at a pH between 1 and 10, and a penetration enhancer, wherein the composition forms a washable and/or a peelable film when sprayed on a skin surface, and wherein the spironolactone does not crystallize when the composition is applied to the skin surface. The disclosure also provides a method of treating acne, male and female pattern hair loss, hirsutism, hidradenitis suppurativa, polycystic ovary syndrome (PCOS), or combinations thereof in a subject in need thereof, the method comprising topically applying the composition described herein as a spray to a skin surface of the subject.