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    Nucleic acids of Rochalimaea henselae and methods and compositions for diagnosing Rochalimaea henselae and Rochalimaea quintana infection
    1.
    发明授权
    Nucleic acids of Rochalimaea henselae and methods and compositions for diagnosing Rochalimaea henselae and Rochalimaea quintana infection 失效
    Ro ae ae ae infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection infection

    公开(公告)号：US5736347A

    公开(公告)日：1998-04-07

    申请号：US307279

    申请日：1994-09-16

    Applicant: Burt E. Anderson ,  Russell L. Regnery

    Inventor： Burt E. Anderson ,  Russell L. Regnery

    IPC: G01N33/569 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  C07K14/195 ,  C07K14/29 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/554 ,  C07K16/00

    CPC classification number: A61K39/0233 ,  C07K14/29 ,  G01N33/56911 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  Y10S435/975 ,  Y10S436/811

    Abstract: A method of diagnosing cat scratch disease and a method of diagnosing bacillary angiomatosis in a subject by detecting the presence of Rochalimaea henselae or an antigenic fragment thereof in the subject is provided. Also provided is a vaccine comprising an immunogenic amount of a nonpathogenic Rochalimaea henselae or an immunogenically specific determinant thereof and a pharmaceutically acceptable carrier. A method of diagnosing Rochalimaea quintana infection in a subject by detecting the presence of a nucleic acid specific to Rochalimaea quintana in a sample from the subject is provided. A purified, 60-kDa heat shock protein of Rochalimaea is provided. Also provided is a 17-kDa antigenic polypeptide of Rochalimaea.

    Abstract translation: 提供了通过检测受试者中禾本科植物或其抗原片段的存在来诊断猫刮伤病的方法和诊断受试者中的杆状血管瘤病的方法。 还提供了一种疫苗，其包含免疫原性量的非致病性禾本科禾本科或其免疫原性特异性决定簇和药学上可接受的载体。 提供了一种通过检测来自受试者的样品中蟑螂特异性的核酸的存在来诊断受试者中的禾草属金丝桃属感染的方法。 提供了一种纯化的，60 kDa的胭脂红热休克蛋白。 还提供了Rochalimaea的17-kDa抗原多肽。

    Activity of new N-acylated ciprofloxacin derivatives against faculative intracellular bacteria
    2.
    发明授权
    Activity of new N-acylated ciprofloxacin derivatives against faculative intracellular bacteria 有权
    新的N-酰化环丙沙星衍生物对细菌细菌的活性

    公开(公告)号：US08143398B1

    公开(公告)日：2012-03-27

    申请号：US13031991

    申请日：2011-02-22

    Applicant: Edward Turos ,  Burt E. Anderson ,  Ryan Scott Cormier ,  John C. Thomas ,  Rebecca J. Kapolka ,  Glenn Roma

    Inventor： Edward Turos ,  Burt E. Anderson ,  Ryan Scott Cormier ,  John C. Thomas ,  Rebecca J. Kapolka ,  Glenn Roma

    IPC: C07D241/04

    CPC classification number: C07D241/04

    Abstract: Bartonella species are facultative intracellular pathogens responsible for a range of diseases in animals and in humans. A selection of N-acyl ciprofloxacin analogues, chemically synthesized from ciprofloxacin, have been tested in vitro for activity against Bartonella species as models for therapeutic development. Nine Bartonella strains, including five of B. henselae, two of B. quintana, and one each of B. elizabethae and B. vinsonii, have been tested for susceptibility to different N-acyl ciprofloxacin derivatives. Several techniques have been used to test the in vitro antibacterial activity of the derivatives. Seven of them, labeled RC4-125, RC4-143, RC4-147, RC5-28, RC5-29, RC5-32 and RC5-69 showed significant intracellular anti-Bartonella activity. These synthetically derived N-acyl ciprofloxacin derivatives may be useful in the therapeutic treatment of infections caused by Bartonella.

    Abstract translation: 巴尔多奈属物种是造成动物和人类各种疾病的兼性细胞内病原体。 已经在体外测试了从环丙沙星化学合成的N-酰基环丙沙星类似物的选择，用于针对巴氏杆菌属物种的活性作为治疗发展的模型。 已经测试了九种巴尔通体菌株，其中包括五种B.henselae，两种金针菇，以及一种每种B. elizabethae和B.vinsonii，已经测试了对不同N-酰基环丙沙星衍生物的易感性。 已经使用几种技术来测试衍生物的体外抗菌活性。 其中7个标记为RC4-125，RC4-143，RC4-147，RC5-28，RC5-29，RC5-32和RC5-69，显示出显着的细胞内抗Bartonella活性。 这些合成衍生的N-酰基环丙沙星衍生物可用于治疗由巴氏杆菌引起的感染的治疗。

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