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    Modified variant bowman birk protease inhibitors
    1.
    发明授权
    Modified variant bowman birk protease inhibitors 有权
    改良型bowman birk蛋白酶抑制剂

    公开(公告)号：US07803902B2

    公开(公告)日：2010-09-28

    申请号：US12252062

    申请日：2008-10-15

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C07K14/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Modified variant Bowman Birk Protease Inhibitors
    3.
    发明授权
    Modified variant Bowman Birk Protease Inhibitors 有权
    改良型Bowman Birk蛋白酶抑制剂

    公开(公告)号：US08394941B2

    公开(公告)日：2013-03-12

    申请号：US13082979

    申请日：2011-04-08

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C12N15/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Modified Variant Bowman Birk Protease Inhibitors
    4.
    发明申请
    Modified Variant Bowman Birk Protease Inhibitors 有权
    改良变体Bowman Birk蛋白酶抑制剂

    公开(公告)号：US20100221780A1

    公开(公告)日：2010-09-02

    申请号：US12779793

    申请日：2010-05-13

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C12P21/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Expression of Streptomyces Subtilisin Inhibitor (SSI) Proteins In Bacillus and Streptomyces sp.
    7.
    发明申请
    Expression of Streptomyces Subtilisin Inhibitor (SSI) Proteins In Bacillus and Streptomyces sp. 审中-公开
    链霉菌枯草杆菌蛋白酶抑制剂（SSI）蛋白在芽孢杆菌和链霉菌中的表达

    公开(公告)号：US20110201535A1

    公开(公告)日：2011-08-18

    申请号：US13091083

    申请日：2011-04-20

    申请人： Bryan P. Fox ,  Huaming Wang

    发明人： Bryan P. Fox ,  Huaming Wang

    IPC分类号： C11D3/60 ,  C12N1/21 ,  C12P21/02

    CPC分类号： C07K14/811

    摘要： Streptomyces and Bacillus host cells comprising a recombinant nucleic acid encoding a fusion protein containing a signal sequence and a Streptomyces subtilisin inhibitor (SSI) protein are provided, as well as methods of producing SSI protein using those cells. In certain embodiments, the host cell is a Streptomyces host cell and the signal to sequence is a celA signal sequence. In other embodiments, the host cell is a Bacillus host cell has a genome that contains inactivated protease genes.

    摘要翻译： 提供了包含编码含有信号序列和Streptomyces枯草杆菌蛋白酶抑制剂（SSI）蛋白的融合蛋白的重组核酸的链霉菌和芽孢杆菌宿主细胞，以及使用这些细胞产生SSI蛋白的方法。 在某些实施方案中，宿主细胞是链霉菌宿主细胞，并且序列信号是celA信号序列。 在其他实施方案中，宿主细胞是具有包含失活的蛋白酶基因的基因组的芽孢杆菌宿主细胞。

    Modified variant Bowman Birk protease inhibitors
    8.
    发明授权
    Modified variant Bowman Birk protease inhibitors 有权
    改良型Bowman Birk蛋白酶抑制剂

    公开(公告)号：US07947475B2

    公开(公告)日：2011-05-24

    申请号：US12779793

    申请日：2010-05-13

    申请人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    发明人： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogtentanz

    IPC分类号： C12P21/00

    CPC分类号： C07K14/811 ,  A61K8/64 ,  A61Q7/02

    摘要： The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    摘要翻译： 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp.
    10.
    发明申请
    Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp. 审中-公开
    Streptomyces subtilism抑制剂（SSI）蛋白在芽孢杆菌和链霉菌中的表达

    公开(公告)号：US20080090745A1

    公开(公告)日：2008-04-17

    申请号：US11580948

    申请日：2006-10-13

    申请人： Bryan P. Fox ,  Huaming Wang

    发明人： Bryan P. Fox ,  Huaming Wang

    IPC分类号： C11D3/386 ,  C07H21/04 ,  C12P21/06 ,  C12N9/56 ,  C12N1/21 ,  C12N15/74

    CPC分类号： C07K14/811

    摘要： Streptomyces and Bacillus host cells comprising a recombinant nucleic acid encoding a fusion protein containing a signal sequence and a Streptomyces subtilisin inhibitor (SSI) protein are provided, as well as methods of producing SSI protein using those cells. In certain embodiments, the host cell is a Streptomyces host cell and the signal sequence is a celA signal sequence. In other embodiments, the host cell is a Bacillus host cell has a genome that contains inactivated protease genes.

    摘要翻译： 提供了包含编码含有信号序列和Streptomyces枯草杆菌蛋白酶抑制剂（SSI）蛋白的融合蛋白的重组核酸的链霉菌和芽孢杆菌宿主细胞，以及使用这些细胞产生SSI蛋白的方法。 在某些实施方案中，宿主细胞是链霉菌宿主细胞，信号序列是celA信号序列。 在其他实施方案中，宿主细胞是具有包含失活的蛋白酶基因的基因组的芽孢杆菌宿主细胞。