公开(公告)号：US20150376168A1

公开(公告)日：2015-12-31

申请号：US14765176

申请日：2014-01-31

申请人： BIOFRONTERA BIOSCIENCE GMBH

发明人： Beate SCHMITZ ,  Hermann LUEBBERT

IPC分类号： C07D409/04

CPC分类号： C07D409/04

摘要： The present invention relates to novel crystal forms of 4-(6-ethoxy-1-methoxy-thioxanthene-9-ylidene)-1-methyl piperidine salts and 4-(6-ethoxy-1-hydroxy-thioxanthene-9-ylidene)-1-methyl piperidine salts; especially to novel crystal forms of 4-(6-ethoxy-1-methoxy-thioxanthene-9-ylidene)-1-methyl piperidine hydrochloride and 4-(6-ethoxy-1-hydroxy-thioxanthene-9-ylidene)-1-methyl piperidine hydrochloride as well as to the use of these salts for preventing or treating migraine or pulmonary hypertension.

摘要翻译： 本发明涉及4-（6-乙氧基-1-甲氧基 - 噻吨-9-亚基）-1-甲基哌啶盐和4-（6-乙氧基-1-羟基 - 噻吨-9-亚基） -1-甲基哌啶盐; 特别是4-（6-乙氧基-1-甲氧基 - 噻吨-9-亚基）-1-甲基哌啶盐酸盐和4-（6-乙氧基-1-羟基 - 噻吨-9-亚基）-1- 甲基哌啶盐酸盐以及这些盐用于预防或治疗偏头痛或肺动脉高压的用途。

公开(公告)号：US20230201087A1

公开(公告)日：2023-06-29

申请号：US18071733

申请日：2022-11-30

申请人： Biofrontera Bioscience GmbH

发明人： Montserrat Foguet Roca

IPC分类号： A61K8/06 ,  A61K8/55 ,  A61Q19/00 ,  A61K8/37 ,  A61K8/44 ,  A61K8/49 ,  B82Y5/00 ,  A61K9/107 ,  A61K8/34

CPC分类号： A61K8/06 ,  A61K8/553 ,  A61Q19/00 ,  A61K8/375 ,  A61K8/44 ,  A61K8/4993 ,  B82Y5/00 ,  A61K9/107 ,  A61K8/34 ,  A61K2800/21 ,  A61K2800/413

摘要： The present invention relates to a nanoemulsion comprising at least one aqueous component and a carrier, wherein the carrier comprises at least one lipophilic component, at least one surfactant and at least one alcohol. The present invention further relates to a composition comprising said nanoemulsion and an active agent. In particular, the composition is present as a gel and the active agent is 5-aminolevulinic acid, a derivative, precursor and/or metabolite thereof. The invention further relates to the preparation of said nanoemulsion and/or composition and to their use for the treatment of dermatological diseases, virus-associated diseases as well as diseases associated with cell proliferation, in particular, tumor diseases and/or psoriasis. The present invention is further directed to the use of said nanoemulsion in cosmetics.

公开(公告)号：US20240335360A1

公开(公告)日：2024-10-10

申请号：US18533521

申请日：2023-12-08

申请人： Biofrontera Bioscience GmbH

发明人： Montserrat FOGUET ,  Mirella GWAREK ,  Lars MÖLLMANN

IPC分类号： A61K8/06 ,  A61K9/107 ,  A61K31/197 ,  A61K47/10 ,  B82Y5/00

CPC分类号： A61K8/068 ,  A61K9/1075 ,  A61K31/197 ,  A61K47/10 ,  A61K2800/30 ,  A61K2800/592 ,  B82Y5/00

摘要： The present invention relates to stabilizing an oil in water nanoemulsion in a pressurized container. The nanovesicles comprised in the nanoemulsion are particularly stable in regard to vesicle size and vesicle size homogeneity after long-term storage at different temperatures.

公开(公告)号：US20240173414A1

公开(公告)日：2024-05-30

申请号：US18188373

申请日：2023-03-22

申请人： BIOFRONTERA BIOSCIENCE GMBH

发明人： Hermann LÜBBERT

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/24 ,  A61N5/06 ,  A61P17/02

CPC分类号： A61K41/0061 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K47/10 ,  A61K47/24 ,  A61N5/0616 ,  A61N5/062 ,  A61P17/02 ,  A61N2005/0663

摘要： The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps:



(a) topical application or subcutaneous injection of said composition to an area of the skin of said patient,
(b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and
(c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer

as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

公开(公告)号：US11642411B2

公开(公告)日：2023-05-09

申请号：US17269816

申请日：2018-08-23

申请人： BIOFRONTERA BIOSCIENCE GMBH

发明人： Hermann Lübbert

IPC分类号： A61N5/06 ,  A61K41/00 ,  A61P17/02 ,  A61K9/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/24

CPC分类号： A61K41/0061 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K47/10 ,  A61K47/24 ,  A61N5/062 ,  A61N5/0616 ,  A61P17/02 ,  A61N2005/0663

摘要： The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps:

(a) topical application or subcutaneous injection of said composition to an area of the skin of said patient,
(b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and
(c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer

as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

公开(公告)号：US20210315993A1

公开(公告)日：2021-10-14

申请号：US17269816

申请日：2018-08-23

申请人： BIOFRONTERA BIOSCIENCE GMBH

发明人： Hermann LÜBBERT

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61N5/06 ,  A61K9/107 ,  A61K47/10 ,  A61K47/24 ,  A61P17/02

摘要： The present invention relates to a composition comprising a photosensitizer use in prevention or treatment of dermatological disease in a patient, wherein the composition is used in the following order of steps: (a) topical application or subcutaneous injection of said composition to an area of the skin of said patient, (b) exposure of at least said area of the skin to light with a wavelength spectrum similar or identical to sun light for a duration of 30 min to 5 hours, and (c) exposure of at least said area of the skin to light of a wavelength spectrum comprising only one maximum in the absorbance spectrum of said photosensitizer as well as to methods of treating dermatological disease using the outlined steps and kits of parts comprising such compositions and light sources suitable to apply the respectively indicated light.

公开(公告)号：US20240335380A1

公开(公告)日：2024-10-10

申请号：US18533497

申请日：2023-12-08

申请人： Biofrontera Bioscience GmbH

发明人： Montserrat FOGUET ,  Lars MÖLLMANN

IPC分类号： A61K9/107 ,  A61K9/127 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/36

CPC分类号： A61K9/1075 ,  A61K9/127 ,  A61K41/0061 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/36

摘要： The present invention relates to oil in water nanoemulsions which are essentially free of propylene glycol. The nanovesicle formulations are particularly stable in regard to shelf life at different storage temperatures.

公开(公告)号：US09708304B2

公开(公告)日：2017-07-18

申请号：US14765176

申请日：2014-01-31

申请人： BIOFRONTERA BIOSCIENCE GMBH

发明人： Beate Schmitz ,  Hermann Luebbert

IPC分类号： C07D211/00 ,  C07D295/00 ,  C07D409/00 ,  C07D411/00 ,  C07D417/00 ,  C07D419/00 ,  A61K31/445 ,  C07D409/04

CPC分类号： C07D409/04

摘要： The present invention relates to novel crystal forms of 4-(6-ethoxy-1-methoxy-thioxanthene-9-ylidene)-1-methyl piperidine salts and 4-(6-ethoxy-1-hydroxy-thioxanthene-9-ylidene)-1-methyl piperidine salts; especially to novel crystal forms of 4-(6-ethoxy-1-methoxy-thioxanthene-9-ylidene)-1-methyl piperidine hydrochloride and 4-(6-ethoxy-1-hydroxy-thioxanthene-9-ylidene)-1-methyl piperidine hydrochloride as well as to the use of these salts for preventing or treating migraine or pulmonary hypertension.