公开(公告)号：US5246930A

公开(公告)日：1993-09-21

申请号：US694203

申请日：1991-05-03

Applicant: Bindumadhavan Venugopalan ,  Chintamani P. Bapat ,  Pravin J. Karnik ,  Bansi Lal ,  Dipak K. Chatterjee ,  Subramani N. Iyer ,  Jurgen Blumbach

Inventor： Bindumadhavan Venugopalan ,  Chintamani P. Bapat ,  Pravin J. Karnik ,  Bansi Lal ,  Dipak K. Chatterjee ,  Subramani N. Iyer ,  Jurgen Blumbach

IPC: A61K31/34 ,  A61P31/12 ,  A61P33/02 ,  C07D493/18 ,  C07D493/20

CPC classification number: C07D493/20

Abstract: Compounds of formula I ##STR1## in which the substituted R has the given meaning, have an antimalarial and a antiviral activity.

公开(公告)号：US5225427A

公开(公告)日：1993-07-06

申请号：US799179

申请日：1991-11-27

Applicant: Bindumadhavan Venugopalan ,  Chintamani P. Bapat ,  Pravin J. Karnik ,  Bansi Lal ,  Dipak K. Chatterjee ,  Subramani N. Iver ,  Richard H. Rupp

Inventor： Bindumadhavan Venugopalan ,  Chintamani P. Bapat ,  Pravin J. Karnik ,  Bansi Lal ,  Dipak K. Chatterjee ,  Subramani N. Iver ,  Richard H. Rupp

IPC: C07D493/18

CPC classification number: C07D493/18

Abstract: 10-substituted ether derivatives of 3.alpha., 12.alpha.-Epoxy-3,4,5 5a.alpha., 6,7,8,8a.alpha.,9,10,12.beta., 12a-dodecahydro-10-hydroxy-3.beta.,6.alpha.,9.beta.-trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroquinghaosu (DHQ), pharmaceutically acceptable salts thereof, processes for their preparation and their use as chemotherapeutics against protozoal infections are provided.

Abstract translation: 3α，12α-环氧-3,4,5αα，6,7,8,8aα，9,10,12β，12a-十二氢-10-羟基-3β，6位的6-取代醚衍生物 提供了还称为二氢青蒿素或二氢喹喔u（DHQ）的α，9β-三甲基吡啶 - （4,3-j）（1,2）苯并二氧杂环己烷，其药学上可接受的盐，其制备方法及其作为抗原虫感染的化学治疗剂的用途 。

公开(公告)号：US5219865A

公开(公告)日：1993-06-15

申请号：US865624

申请日：1992-04-09

Applicant: Dipak C. Chatterjee ,  Bindumadhavan Venugopalan ,  Bansi Lal ,  Noel J. de Souza ,  Richard H. Rupp

Inventor： Dipak C. Chatterjee ,  Bindumadhavan Venugopalan ,  Bansi Lal ,  Noel J. de Souza ,  Richard H. Rupp

IPC: A61K31/47 ,  A61K31/49 ,  A61K31/635

CPC classification number: A61K31/47 ,  A61K31/49 ,  A61K31/635

Abstract: The present invention relates to combinations of the malaria therapeutics artemisinine, dihydroartemisinine, arteether, artemether, artesunate or other artemisinine derivatives with one or more of the antimalarials chloroquine, 10-0-methylfloxacrine, quinine, mefloquine, amodiaquine, pyrimethamine, sulfadoxine and primaquine. Synergistic actions are achieved with them on treatment of mammals, including humans, with subcurative doses of the individual substances.

Abstract translation: 本发明涉及疟疾治疗剂青蒿素，二氢青蒿素，蒿甲醚，蒿甲醚，青蒿琥酯或其他青蒿素衍生物与一种或多种抗疟药氯喹，10-0-甲基氟沙星，奎宁，甲氟喹，阿莫奇喹，乙胺嘧啶，磺胺多辛和伯氨喹的组合。 协同作用是通过使用亚单位剂量的个别物质来治疗包括人类的哺乳动物。

公开(公告)号：US4803204A

公开(公告)日：1989-02-07

申请号：US75643

申请日：1987-07-20

Applicant: Rajkumar Dhar ,  Bindumadhavan Venugopalan ,  Dipak K. Chatterjee ,  Richard H. Rupp ,  Noel J. de Souza

Inventor： Rajkumar Dhar ,  Bindumadhavan Venugopalan ,  Dipak K. Chatterjee ,  Richard H. Rupp ,  Noel J. de Souza

IPC: A23K1/16 ,  A61K31/435 ,  A61K31/535 ,  A61P33/02 ,  C07D219/06 ,  C07D219/08 ,  C07D401/04 ,  A61K31/47

CPC classification number: C07D219/08

Abstract: The present invention relates to novel, 1-substituted 3-aryl-7-chloro-3,4-dihydro-(2H)-acridone N-oxides, a process for their preparation, pharmaceutical compositions containing these compounds, and their use as chemotherapeutic agents, in particular as antimalarials and coccidiostatics.

Abstract translation: 本发明涉及新的1-取代的3-芳基-7-氯-3,4-二氢 - （2H） - 吖啶酮N-氧化物，其制备方法，含有这些化合物的药物组合物及其作为化学治疗剂的用途 药剂，特别是抗疟药和球虫病。