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公开(公告)号：US20190307866A1
公开(公告)日：2019-10-10
申请号：US16442624
申请日：2019-06-17
发明人： Ilana Nathan , Eli Lewis , Boris Khalfin
摘要： The present invention is related to the use of alpha-1-antitrypsin as an anti-necrotic agent. This invention provides a method for the treatment of tissue necrosis by administration of alpha-1-antitrypsin. This invention further provides methods for prophylactic treatment of tissue necrosis and for inhibition of tissue necrosis in culture by addition of alpha-1-antitrypsin.
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2.发明申请公开(公告)号：US20190225653A1
公开(公告)日：2019-07-25
申请号：US16205275
申请日：2018-11-30
发明人： Ayelet DAVID , Gonen ASHKENASY , Yosi SHAMAY
摘要： The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticle pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.
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3.发明授权公开(公告)号：US10245556B2
公开(公告)日：2019-04-02
申请号：US14394519
申请日：2013-04-15
发明人： Jack Gilron , Dan Peled , Yevgeny Goldkine , Sivan Bleich
IPC分类号： B01D61/12 , B01D61/02 , B01D65/08 , C02F1/44 , B01D61/00 , B01D63/00 , B01D65/02 , C02F103/08 , C02F1/00
摘要： A system and method for switching between flows of water solutions passed in groups of blocks of membrane pressure vessels arranged in parallel in a tapered flow system, wherein the system comprises a system inlet feed line, a system outlet flow line, high pressure booster pumps configured to provide a high pressure feed stream to the system; blocks of membrane pressure vessels arrayed in parallel, and a first and second bypass line each parallel to said blocks.
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4.发明申请公开(公告)号：US20180021733A2
公开(公告)日：2018-01-25
申请号：US14394519
申请日：2013-04-15
申请人： Ben Gurion University of the Negev Research and Development Authority , Mekorot Water Company Ltd.
发明人： Jack GILRON , Dan PELED , Yevgeny GOLDKINE , Sivan BLEICH
CPC分类号： B01D65/02 , B01D61/022 , B01D61/12 , B01D63/00 , B01D65/027 , B01D65/08 , B01D2313/48 , B01D2317/027 , B01D2317/04 , B01D2321/40 , C02F1/008 , C02F1/44 , C02F1/441 , C02F1/442 , C02F2103/08 , C02F2209/03 , C02F2303/22 , Y02A20/131
摘要： A system and method for switching between flows of water solutions passed in groups of blocks of membrane pressure vessels arranged in parallel in a tapered flow system, wherein the system comprises a system inlet feed line, a system outlet flow line, high pressure booster pumps configured to provide a high pressure feed stream to the system; blocks of membrane pressure vessels arrayed in parallel, and a first and second bypass line each parallel to said blocks.
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公开(公告)号：US20170305837A1
公开(公告)日：2017-10-26
申请号：US15589501
申请日：2017-05-08
发明人： Esther PRIEL
IPC分类号： C07C215/80 , A61K31/03 , C07D295/096 , C07D213/30 , C07D213/16 , C07C215/50 , C07C43/23 , C07C43/225 , C07C39/367 , A61K31/695 , A61K31/66 , A61K31/136 , A61K31/055 , A61K31/05 , C07D295/135 , C07F9/50
CPC分类号： C07C215/80 , A61K31/03 , A61K31/05 , A61K31/055 , A61K31/136 , A61K31/66 , A61K31/695 , C07C39/367 , C07C43/225 , C07C43/23 , C07C215/50 , C07D213/16 , C07D213/30 , C07D295/096 , C07D295/135 , C07F9/5022
摘要： The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.
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公开(公告)号：US09731046B2
公开(公告)日：2017-08-15
申请号：US14380161
申请日：2013-02-21
发明人： Smadar Cohen , Tali Re'Em , Emil Ruvinov
CPC分类号： A61L27/26 , A61K9/0024 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/60 , A61L2430/02
摘要： The present invention provides a multi-compartment hydrogel, and a sulfated polysaccharide and at least two bioactive polypeptides capable of binding said sulfated polysaccharide, for use in repair or regeneration of a damaged tissue in a mammal. Also provided is a method for constructing the multi-compartment hydrogel. The present invention also provides a method for the repair or regeneration of a damaged tissue in a mammal, and a kit for constructing a multi-compartment hydrogel.
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7.发明申请公开(公告)号：US20170202961A1
公开(公告)日：2017-07-20
申请号：US15477379
申请日：2017-04-03
发明人： Eli LEWIS
CPC分类号： A61K39/395 , A61K35/39 , A61K38/14 , A61K38/191 , A61K38/217 , A61K38/57 , A61K39/39541 , A61K39/3955 , A61K2039/505 , C07K16/40 , A61K2300/00
摘要： A method of preventing or treating xenotransplant rejection in a subject in need thereof is disclosed. The method comprises administering a therapeutically effective amount of alpha-1-antitrypsin (AAT) in combination with a therapeutically effective amount of an anti-CD8 antibody or an antigen binding fragment thereof.
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公开(公告)号：US20160002286A1
公开(公告)日：2016-01-07
申请号：US14859983
申请日：2015-09-21
发明人： Ashraf BRIK , Mahmood HAJ-YAHYA , Ajish KUMAR , Leslie ERLICH , Liat SPASSER
CPC分类号： C07K1/1077 , C07K1/1075 , C07K14/00 , C07K14/001 , C07K14/47
摘要： The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them.
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9.发明申请DEVICE AND METHODOLOGY FOR MEASURING MINUTE CHANGES IN AMBIENT MAGNETIC FIELD 审中-公开用于测量环境磁场中的微小变化的装置和方法公开(公告)号：US20150377989A1
公开(公告)日：2015-12-31
申请号：US14766250
申请日：2014-02-03
IPC分类号： G01R33/26
摘要： An optical magnetometer comprising: a response frequency measurement unit comprising a vapor cell, a pulsed-mode pump laser and a probe laser; and a computing unit configured to compute a magnetic field change based on a difference between at least two temporally-distinct response frequency values received from the frequency measurement unit. Optionally, the response frequency measurement unit is magnetically non-shielded.
摘要翻译： 一种光学磁力计，包括：响应频率测量单元，包括蒸汽单元，脉冲模式泵浦激光器和探针激光器; 以及计算单元，被配置为基于从所述频率测量单元接收的至少两个时间上不同的响应频率值之间的差来计算磁场变化。 可选地，响应频率测量单元是非磁屏蔽的。
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公开(公告)号：US20150253502A1
公开(公告)日：2015-09-10
申请号：US14427756
申请日：2013-09-11
发明人： Alexander Fish , Zeev Zalevsky , Amihai Meiri , Ori Bass
IPC分类号： G02B6/122
CPC分类号： G02B6/1225 , B82Y20/00 , G02B6/12004 , G02B6/12007 , G02B6/122 , G06E3/005
摘要： An integrated circuit with electronic and photonic elements includes: at least one electronic processing layer; at least one interconnect layer adjacent to said electronic processing layer, and at least one photonic element located within a respective interconnect layer. The photonic elements implement respective operations upon optical signals. At least a portion of each interconnect layer which includes photonic elements is optically-conductive, and therefore suitable for the inclusion of the photonic elements.In some embodiments said photonic elements comprising optical waveguides are configures as optical logic gates to perform logic operations.
摘要翻译： 具有电子和光子元件的集成电路包括：至少一个电子处理层; 与所述电子处理层相邻的至少一个互连层和位于相应互连层内的至少一个光子元件。 光子元件根据光信号实现各自的操作。 包括光子元件的每个互连层的至少一部分是光学导电的，因此适合于包含光子元件。 在一些实施例中，包括光波导的所述光子元件被配置为执行逻辑运算的光逻辑门。
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