-
-
-
-
-
-
公开(公告)号：US20140249089A1
公开(公告)日：2014-09-04
申请号：US14169672
申请日：2014-01-31
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zannelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zannelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC分类号： C07K14/435
CPC分类号： C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
-
公开(公告)号：US08475779B2
公开(公告)日：2013-07-02
申请号：US12637723
申请日：2009-12-14
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用包含氨基酸酪氨酸（Y），苯丙氨酸（F），丙氨酸（A）和赖氨酸（K））的无规共聚物来治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
-
公开(公告)号：US20080194462A1
公开(公告)日：2008-08-14
申请号：US10591315
申请日：2005-09-15
申请人： Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
发明人： Kai Wucherpfennig , James Rasmussen , Bei Yu , Eric Zanelli , Jack L. Strominger
IPC分类号： A61K38/28 , A61K38/16 , G01N33/566 , A61P3/10 , A61P37/00
CPC分类号： A61K38/02
摘要： The present invention provides methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses. The copolymers are random copolymers of amino acids and copolymers comprising anchor residues to facilitate binding to the DQ binding pockets.
摘要翻译： 本发明提供用于治疗自身免疫性疾病和其他不需要的免疫反应的方法和组合物，其包括施用与一种或多种HLA-DQ分子结合并调节DQ限制性T细胞应答的共聚物。 共聚物是氨基酸的无规共聚物和包含锚定残基的共聚物，以便于结合DQ结合袋。
-
公开(公告)号：US20060194725A1
公开(公告)日：2006-08-31
申请号：US11283405
申请日：2005-11-17
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson , Jeff Krieger
IPC分类号： A61K38/17
CPC分类号： C07K14/435 , A61K9/0019 , A61K31/785 , A61K38/02
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
摘要翻译： 本发明涉及通过施用无规共聚物治疗或预防疾病的新方法和试剂盒。 本发明还涉及自身免疫性疾病如多发性硬化的治疗，以及在包含以大于24小时的间隔施用的制剂的治疗方案中施用无规共聚物，或者涉及在一段时间内施用共聚物的持续释放制剂 超过24小时。 本发明还涉及用于进行药物业务的方法，其包括制造，许可或分发包含本文所述的无规共聚物的制剂或给药方案的试剂盒。
-
公开(公告)号：US20060189527A1
公开(公告)日：2006-08-24
申请号：US11283406
申请日：2005-11-17
申请人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
发明人： James Rasmussen , Jianxin Zhang , Sam Baldwin , Eric Zanelli , Bei Yu , Dustan Bonnin , Keith Johnson
IPC分类号： A61K38/16
CPC分类号： A61K38/02 , A61K38/16 , A61K2300/00
摘要： The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers. The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.029 秒)
