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公开(公告)号：US07960535B2
公开(公告)日：2011-06-14
申请号：US12619357
申请日：2009-11-16
CPC分类号： C07K14/3156 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
摘要翻译： 本发明涉及重组脂化的PsaA蛋白和重组构建体，其中可以表达这种脂质化的PsaA蛋白。 本发明进一步涉及脂质化PsaA蛋白，其中通过使用源自博氏疏螺旋体的ospA基因的异源前导序列来实现脂化，该引导序列与psaA结构基因连接在翻译阅读框中。 本发明还提供了脂质化PsaA蛋白的制备方法和这些蛋白质在免疫组合物中的应用。 还提供了包含免疫原性脂化PsaA蛋白的疫苗以及这种疫苗在预防和治疗肺炎链球菌感染中的使用方法。
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公开(公告)号：US07635486B1
公开(公告)日：2009-12-22
申请号：US09600057
申请日：1999-01-14
CPC分类号： C07K14/3156 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
摘要翻译： 本发明涉及重组脂化的PsaA蛋白和重组构建体，其中可以表达这种脂质化的PsaA蛋白。 本发明进一步涉及脂质化PsaA蛋白，其中通过使用源自博氏疏螺旋体的ospA基因的异源前导序列来实现脂化，该引导序列与psaA结构基因连接在翻译阅读框中。 本发明还提供了脂质化PsaA蛋白的制备方法和这些蛋白质在免疫组合物中的应用。 还提供了包含免疫原性脂化PsaA蛋白的疫苗以及这种疫苗在预防和治疗肺炎链球菌感染中的使用方法。
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公开(公告)号：US20100260802A1
公开(公告)日：2010-10-14
申请号：US12619357
申请日：2009-11-16
CPC分类号： C07K14/3156 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
摘要翻译： 本发明涉及重组脂化的PsaA蛋白和重组构建体，其中可以表达这种脂质化的PsaA蛋白。 本发明进一步涉及脂质化PsaA蛋白，其中通过使用源自博氏疏螺旋体的ospA基因的异源前导序列来实现脂化，该引导序列与psaA结构基因连接在翻译阅读框中。 本发明还提供了脂质化PsaA蛋白的制备方法和这些蛋白质在免疫组合物中的应用。 还提供了包含免疫原性脂化PsaA蛋白的疫苗以及这种疫苗在预防和治疗肺炎链球菌感染中的使用方法。
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