发明授权
US07960535B2 Recombinant lipidated PsaA protein, methods of preparation and use
失效
重组脂质化PsaA蛋白，制备和使用方法
- 专利标题： Recombinant lipidated PsaA protein, methods of preparation and use
- 专利标题（中）： 重组脂质化PsaA蛋白，制备和使用方法
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申请号： US12619357申请日： 2009-11-16
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公开(公告)号： US07960535B2公开(公告)日： 2011-06-14
- 发明人: Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
- 申请人： Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; A61K49/00
摘要：
The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
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