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    Stimulation of tanning by DNA fragments or single-stranded DNA
    4.
    发明授权
    Stimulation of tanning by DNA fragments or single-stranded DNA 失效
    通过DNA片段或单链DNA刺激鞣制

    公开(公告)号：US5470577A

    公开(公告)日：1995-11-28

    申请号：US88251

    申请日：1993-07-07

    申请人： Barbara A. Gilchrest ,  Mina Yaar ,  Mark Eller

    发明人： Barbara A. Gilchrest ,  Mina Yaar ,  Mark Eller

    IPC分类号： A61K8/60 ,  A61K45/06 ,  A61Q19/04 ,  A61K37/22 ,  A61K9/50

    CPC分类号： A61Q19/04 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7048 ,  A61K45/06 ,  A61K8/606

    摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.

    摘要翻译： 公开了一种增加哺乳动物皮肤色素沉着的方法，以及保护哺乳动物皮肤免受紫外线损害。 还公开了增加哺乳动物细胞中色素沉积的方法，以及增强哺乳动物黑素细胞中黑色素产生的方法。 另外公开了本发明方法中有用的制剂。 所述方法包括在脂质体制剂或其它合适的载体中向表皮或细胞施用单链或双链或二者或脱氧核苷酸的混合物的DNA片段。 该制剂包括DNA片段或脱氧核苷酸以及合适的递送载体，例如脂质体。

    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES
    6.
    发明申请
    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES 审中-公开
    使用寡核苷酸抑制细胞生长的方法

    公开(公告)号：US20110237654A1

    公开(公告)日：2011-09-29

    申请号：US13008785

    申请日：2011-01-18

    申请人： Barbara A. Gilchrest ,  Mark S. Eller

    发明人： Barbara A. Gilchrest ,  Mark S. Eller

    IPC分类号： A61K31/7088 ,  C12N5/095 ,  C07H21/04 ,  A61P35/00 ,  A61P35/02

    CPC分类号： A61K31/7088

    摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful for treating other cancers, such as for example pancreatic cancer and eradicating cancer stem cells.

    摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增殖性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症，例如胰腺癌和根除癌症干细胞。

    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES
    7.
    发明申请
    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES 失效
    使用寡核苷酸抑制细胞生长的方法

    公开(公告)号：US20100249218A1

    公开(公告)日：2010-09-30

    申请号：US12715242

    申请日：2010-03-01

    申请人： Barbara A. GILCHREST ,  Mark S. Eller

    发明人： Barbara A. GILCHREST ,  Mark S. Eller

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  A61P35/00

    CPC分类号： A61K31/711 ,  A61K31/7088 ,  A61K31/7125 ,  A61K31/713

    摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.

    摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。

    Use of locally applied DNA fragments
    9.
    发明授权
    Use of locally applied DNA fragments 失效
    使用局部应用的DNA片段

    公开(公告)号：US07094766B1

    公开(公告)日：2006-08-22

    申请号：US09540843

    申请日：2000-03-31

    申请人： Barbara A. Gilchrest ,  Mina Yaar ,  Mark Eller

    发明人： Barbara A. Gilchrest ,  Mina Yaar ,  Mark Eller

    IPC分类号： A61K31/70 ,  A01N43/04

    CPC分类号： A61Q17/04 ,  A61K8/606 ,  A61K9/0014 ,  A61K31/70 ,  A61K2800/86 ,  A61Q19/08

    摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.

    摘要翻译： 治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生或紫外线反应性皮肤病的过度增殖性疾病或癌前病症的方法，其他上皮细胞的过度增生或过敏介导的疾病以及减少光老化或氧化的方法 公开了压力或用于预防或减少皮肤癌发展的可能性。

    Inhibition of &bgr;-amyloid binding to the p75 nerve growth factor receptor
    10.
    发明授权
    Inhibition of &bgr;-amyloid binding to the p75 nerve growth factor receptor 失效
    抑制β-淀粉样蛋白结合p75神经生长因子受体

    公开(公告)号：US06242416B1

    公开(公告)日：2001-06-05

    申请号：US09163095

    申请日：1998-09-29

    申请人： Barbara A. Gilchrest ,  Mina Yaar

    发明人： Barbara A. Gilchrest ,  Mina Yaar

    IPC分类号： A61K3800

    CPC分类号： C07K5/0815 ,  A61K38/00 ,  C07K14/4711 ,  C07K14/48 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

    摘要： Methods of inhibiting &bgr;-amyloid-mediated activation of the p75 nerve growth factor receptor of a cell that expresses the p75 nerve growth factor receptor are provided. Methods of inhibiting the binding of &bgr;-amyloid protein and &bgr;-amyloid peptides to the p75 nerve growth factor receptor, and methods of inhibiting &bgr;-amyloid-mediated apoptosis of neural crest-derived cells are provided. The methods comprise contacting the cell with a substance, comprising, for example, the amino acid sequence lysine-glycine-lysine (KGK) or lysine-glycine-alanine (KGA), wherein the substance binds to the p75 nerve growth factor receptor, resulting in the inhibition of &bgr;-amyloid protein or &bgr;-amyloid peptide binding to and/or activation of the p75 nerve growth factor receptor, or wherein the substance inhibits &bgr;-amyloid protein or &bgr;-amyloid peptide mediated apoptosis of the cell which expresses the p75 nerve growth factor receptor.

    摘要翻译： 提供了抑制β-淀粉样蛋白介导的表达p75神经生长因子受体的细胞的p75神经生长因子受体活化的方法。 提供了抑制β-淀粉样蛋白和β-淀粉样肽与p75神经生长因子受体结合的方法，以及抑制β-淀粉样蛋白介导的神经嵴衍生细胞凋亡的方法。 所述方法包括使细胞与包含例如氨基酸序列赖氨酸 - 甘氨酸 - 赖氨酸（KGK）或赖氨酸 - 甘氨酸 - 丙氨酸（KGA）的物质接触，其中所述物质与p75神经生长因子受体结合，得到 在β-淀粉样蛋白或β-淀粉样肽与p75神经生长因子受体结合和/或活化的抑制中，或其中该物质抑制β-淀粉样蛋白或β-淀粉样肽介导的表达p75的细胞的凋亡 神经生长因子受体。