知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

40 条记录 (耗时 0.023 秒)

    Stable liquid desoximethasone compositions with reduced oxidized impurity
    1.
    发明授权
    Stable liquid desoximethasone compositions with reduced oxidized impurity 有权
    具有减少的氧化杂质的稳定的液体脱氧阿司他酮组合物

    公开(公告)号：US08715624B2

    公开(公告)日：2014-05-06

    申请号：US13605622

    申请日：2012-09-06

    申请人： Srinivasa Rao ,  Suresh Dixit ,  Avraham Yacobi ,  Arthur Bailey

    发明人： Srinivasa Rao ,  Suresh Dixit ,  Avraham Yacobi ,  Arthur Bailey

    IPC分类号： A61K9/08 ,  A61K31/573 ,  A61K9/12 ,  A61K9/14

    CPC分类号： A61K31/573 ,  A61K9/008 ,  A61K9/12

    摘要： The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C2-C4 alcohol and a stabilizing agent. Specifically, the present invention provides a liquid formulation comprising: a) about 0.01 wt % to about 2.5 wt % desoximetasone; b) about 10 wt % to about 70 wt % isopropyl myristate; c) about 20 wt % to about 70 wt % C2-C4 alcohol; and d) a stabilizing agent selected from the group consisting of an oleaginous vehicle and a propellant, wherein the stabilizing agent is in an amount sufficient to reduce the formation of less than about 1 wt % 17-carboxy-9α-fluoro-11β-hydroxy-16α-methyl-androsta-1,4-diene-3-one under an accelerated storage condition.

    摘要翻译： 本发明涉及包含脱邻醌，肉豆蔻酸异丙酯，C 2 -C 4醇和稳定剂的稳定的液体制剂。 具体而言，本发明提供了一种液体制剂，其包含：a）约0.01重量％至约2.5重量％的去氧阿司他酮; b）约10重量％至约70重量％的肉豆蔻酸异丙酯; c）约20重量％至约70重量％的C 2 -C 4醇; 和d）选自油性载体和推进剂的稳定剂，其中稳定剂的量足以减少小于约1重量％的17-羧基-9α-氟-11β- 羟基-16α-甲基 - 雄甾-1,4-二烯-3-酮。

    Non-sedating barbiturate compounds as neuroprotective agents
    5.
    发明申请
    Non-sedating barbiturate compounds as neuroprotective agents 失效
    非镇静巴比妥酸化合物作为神经保护剂

    公开(公告)号：US20060205747A1

    公开(公告)日：2006-09-14

    申请号：US11355336

    申请日：2006-02-16

    申请人： Daniel Moros ,  Barrie Levitt ,  Avraham Yacobi

    发明人： Daniel Moros ,  Barrie Levitt ,  Avraham Yacobi

    IPC分类号： A61K31/515

    CPC分类号： A61K31/515 ,  A61K31/5377 ,  A61K31/541

    摘要： Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. Preferred doses for a neuroprotective effect exceed the dosage of a corresponding sedative barbiturate without sedative side-effects such as anesthesia and death.

    摘要翻译： 公开了提供神经保护作用的方法，其包括施用足以在哺乳动物受试者中实现神经保护的量的非镇静性巴比妥类化合物。 优选的化合物是二苯基巴比妥酸和类似物的族。 神经保护作用的优选剂量超过相应的镇静剂巴比妥酸盐的剂量，而没有镇静剂副作用，如麻醉和死亡。

    STABLE LIQUID DESOXIMETHASONE COMPOSITIONS WITH REDUCED OXIDIZED IMPURITY
    7.
    发明申请
    STABLE LIQUID DESOXIMETHASONE COMPOSITIONS WITH REDUCED OXIDIZED IMPURITY 有权
    稳定的液体脱氧酮组合物具有降低的氧化污染

    公开(公告)号：US20120328531A1

    公开(公告)日：2012-12-27

    申请号：US13605622

    申请日：2012-09-06

    申请人： Srinivasa Rao ,  Suresh Dixit ,  Avraham Yacobi ,  Arthur Bailey

    发明人： Srinivasa Rao ,  Suresh Dixit ,  Avraham Yacobi ,  Arthur Bailey

    IPC分类号： A61K31/573 ,  A61P17/06 ,  A61P17/00

    CPC分类号： A61K31/573 ,  A61K9/008 ,  A61K9/12

    摘要： The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C2-C4 alcohol and a stabilizing agent. Specifically, the present invention provides a liquid formulation comprising: a) about 0.01 wt % to about 2.5 wt % desoximetasone; b) about 10 wt % to about 70 wt % isopropyl myristate; c) about 20 wt % to about 70 wt % C2-C4 alcohol; and d) a stabilizing agent selected from the group consisting of an oleaginous vehicle and a propellant, wherein the stabilizing agent is in an amount sufficient to reduce the formation of less than about 1 wt % 17-carboxy-9α-fluoro-11β-hydroxy-16α-methyl-androsta-1,4-diene-3-one under an accelerated storage condition.

    摘要翻译： 本发明涉及包含脱邻醌，肉豆蔻酸异丙酯，C 2 -C 4醇和稳定剂的稳定的液体制剂。 具体而言，本发明提供了一种液体制剂，其包含：a）约0.01重量％至约2.5重量％的去氧阿司他酮; b）约10重量％至约70重量％的肉豆蔻酸异丙酯; c）约20重量％至约70重量％的C 2 -C 4醇; 和d）选自油性载体和推进剂的稳定剂，其中稳定剂的量足以减少少于约1重量％的17-羧基-9α-氟-11β- 羟基-16α-甲基 - 雄甾-1,4-二烯-3-酮。

    Topical gel formulation comprising organophosphate insecticide and preparation thereof
    8.
    发明授权
    Topical gel formulation comprising organophosphate insecticide and preparation thereof 有权
    包含有机磷酸酯杀虫剂的局部凝胶制剂及其制备

    公开(公告)号：US08158139B2

    公开(公告)日：2012-04-17

    申请号：US11351188

    申请日：2006-02-09

    申请人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

    发明人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

    IPC分类号： A01N57/10 ,  A01N57/12 ,  A01N25/02 ,  A61K9/08 ,  A61K31/661 ,  A61K47/10 ,  A61K47/14 ,  A61P33/14

    CPC分类号： A01N25/04 ,  A01N43/30 ,  A01N57/12 ,  A01N57/14 ,  A01N57/16

    摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present topical formulations encompass a non-flammable solvent for malathion effective in killing head lice. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

    摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的局部制剂包含用于杀死头虱的马拉硫磷的非易燃溶剂。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。

    NON-SEDATING BARBITURATE COMPOUNDS AS NEUROPROTECTIVE AGENTS
    9.
    发明申请
    NON-SEDATING BARBITURATE COMPOUNDS AS NEUROPROTECTIVE AGENTS 失效
    作为神经保护剂的非离子型硼酸盐化合物

    公开(公告)号：US20100197709A1

    公开(公告)日：2010-08-05

    申请号：US12759264

    申请日：2010-04-13

    申请人： Daniel A. Moros ,  Barrie Levitt ,  Avraham Yacobi

    发明人： Daniel A. Moros ,  Barrie Levitt ,  Avraham Yacobi

    IPC分类号： A61K31/515 ,  A61P9/10 ,  A61P43/00 ,  C07D239/62

    CPC分类号： A61K31/515 ,  A61K31/5377 ,  A61K31/541

    摘要： Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. Preferred doses for a neuroprotective effect exceed the dosage of a corresponding sedative barbiturate without sedative side-effects such as anesthesia and death.

    摘要翻译： 公开了提供神经保护作用的方法，其包括施用足以在哺乳动物受试者中实现神经保护的量的非镇静性巴比妥类化合物。 优选的化合物是二苯基巴比妥酸和类似物的族。 神经保护作用的优选剂量超过相应的镇静剂巴比妥酸盐的剂量，而没有镇静剂副作用，如麻醉和死亡。