公开(公告)号：US08012498B2

公开(公告)日：2011-09-06

申请号：US11179719

申请日：2005-07-12

申请人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

发明人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

IPC分类号： A01N57/10 ,  A01N57/12 ,  A61K9/06 ,  A61K31/661 ,  A61K47/38 ,  A61P33/14

CPC分类号： A01N57/14 ,  A01N25/04 ,  A01N37/02 ,  A01N53/00 ,  A01N57/12 ,  A01N57/16 ,  A01N31/02 ,  A01N31/08 ,  A01N2300/00

摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。

公开(公告)号：US06656505B2

公开(公告)日：2003-12-02

申请号：US09621623

申请日：2000-07-21

申请人： Subhas Kundu ,  Vivek Desai ,  Andrea Cameron

发明人： Subhas Kundu ,  Vivek Desai ,  Andrea Cameron

IPC分类号： A61K910

CPC分类号： A61K9/0095 ,  A61K9/10 ,  A61K47/20

摘要： An aqueous pharmaceutical composition suitable for oral delivery has an insoluble active substance and a wetting agent in liquid suspension. The composition contains floccules of the active ingredient. The formulation has an excellent shelf-life in which caking and sedimentation are inhibited. The composition may be resuspended upon light to moderate shaking.

摘要翻译： 适于口服给药的水性药物组合物在液体悬浮液中具有不溶性活性物质和润湿剂。 组合物含有活性成分的絮凝物。 该制剂具有优异的保质期，其中结块和沉淀被抑制。 可以将组合物重新悬浮于轻度至中度摇动。

公开(公告)号：US20120172338A1

公开(公告)日：2012-07-05

申请号：US13409502

申请日：2012-03-01

申请人： SANDHYA GOYAL ,  Subhas Kundu ,  Daniel Moros ,  Howard Ruman ,  Avraham Yacobi

发明人： SANDHYA GOYAL ,  Subhas Kundu ,  Daniel Moros ,  Howard Ruman ,  Avraham Yacobi

IPC分类号： A61K31/661 ,  A61P33/14

CPC分类号： A01N25/04 ,  A01N43/30 ,  A01N57/12 ,  A01N57/14 ,  A01N57/16

摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present topical formulations encompass a non-flammable solvent for malathion effective in killing head lice. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的局部制剂包含用于杀死头虱的马拉硫磷的非易燃溶剂。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。

公开(公告)号：US20120053153A1

公开(公告)日：2012-03-01

申请号：US13220935

申请日：2011-08-30

申请人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

发明人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

IPC分类号： A61K31/6615 ,  A61P33/14

CPC分类号： A01N57/14 ,  A01N25/04 ,  A01N37/02 ,  A01N53/00 ,  A01N57/12 ,  A01N57/16 ,  A01N31/02 ,  A01N31/08 ,  A01N2300/00

摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。

公开(公告)号：US20060084632A1

公开(公告)日：2006-04-20

申请号：US11179719

申请日：2005-07-12

申请人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

发明人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

IPC分类号： A01N65/00 ,  A01N57/00

CPC分类号： A01N57/14 ,  A01N25/04 ,  A01N37/02 ,  A01N53/00 ,  A01N57/12 ,  A01N57/16 ,  A01N31/02 ,  A01N31/08 ,  A01N2300/00

摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。

公开(公告)号：US08158139B2

公开(公告)日：2012-04-17

申请号：US11351188

申请日：2006-02-09

申请人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

发明人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

IPC分类号： A01N57/10 ,  A01N57/12 ,  A01N25/02 ,  A61K9/08 ,  A61K31/661 ,  A61K47/10 ,  A61K47/14 ,  A61P33/14

CPC分类号： A01N25/04 ,  A01N43/30 ,  A01N57/12 ,  A01N57/14 ,  A01N57/16

摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present topical formulations encompass a non-flammable solvent for malathion effective in killing head lice. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的局部制剂包含用于杀死头虱的马拉硫磷的非易燃溶剂。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。

公开(公告)号：US20070065474A1

公开(公告)日：2007-03-22

申请号：US11351188

申请日：2006-02-09

申请人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

发明人： Sandhya Goyal ,  Subhas Kundu ,  Daniel Moros ,  Howard Rutman ,  Avraham Yacobi

IPC分类号： A01N57/00 ,  A01N25/00

CPC分类号： A01N25/04 ,  A01N43/30 ,  A01N57/12 ,  A01N57/14 ,  A01N57/16

摘要： The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0.1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present topical formulations encompass a non-flammable solvent for malathion effective in killing head lice. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.

摘要翻译： 本发明提供适用于治疗哺乳动物的外寄生物的杀虫剂的局部凝胶药物制剂，其包含：a）约0.1-10重量％的杀虫剂; b）至少约75重量％的选自低级烷基醇，酮，二醇及其混合物的有机溶剂，其中有机溶剂含有至少约40重量％的低级烷基 醇; 和c）至少一种选自纤维素聚合物，丙烯酸酯，甲基丙烯酸酯和聚乙烯吡咯烷酮的聚合物。 本发明的局部制剂包含用于杀死头虱的马拉硫磷的非易燃溶剂。 本发明的凝胶药物制剂优选含有马拉硫磷，并且任选地含有肉豆蔻酸异丙酯。 本发明还提供一种制备方法以及使用其制备哺乳动物体外寄生虫的方法。