公开(公告)号：US08362236B2

公开(公告)日：2013-01-29

申请号：US12529222

申请日：2008-02-29

申请人： Nobuo Shimma ,  Takuo Tsukuda ,  Hiroshi Koyano ,  Atsushi Suda ,  Tadakatsu Hayase ,  Kihito Hada ,  Ken-Ichi Kawasaki ,  Susumu Komiyama ,  Naomi Ono ,  Toshikazu Yamazaki ,  Ryoichi Saitoh ,  Masami Kohchi ,  Kiyoshi Hasegawa

发明人： Nobuo Shimma ,  Takuo Tsukuda ,  Hiroshi Koyano ,  Atsushi Suda ,  Tadakatsu Hayase ,  Kihito Hada ,  Ken-Ichi Kawasaki ,  Susumu Komiyama ,  Naomi Ono ,  Toshikazu Yamazaki ,  Ryoichi Saitoh ,  Masami Kohchi ,  Kiyoshi Hasegawa

IPC分类号： C07D497/08 ,  C07D513/08 ,  C07D513/20 ,  A61K31/529 ,  A61K31/53 ,  A61K31/5377 ,  A61P35/00

CPC分类号： C07D497/08 ,  C07D513/08 ,  C07D513/18 ,  C07D513/20

摘要： The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.

摘要翻译： 本发明提供具有抑制HSP90酶的活性的新型化合物，可用作抗癌剂等，以及可用作其合成中间体的化合物。 具体而言，本发明提供下述式（1）表示的化合物及其药学上可接受的盐：其中X，R1，R2，R3，R4，R5，R6，R7，L1，L2和L3如 规范。

公开(公告)号：US20100056510A1

公开(公告)日：2010-03-04

申请号：US12529222

申请日：2008-02-29

申请人： Nobuo Shimma ,  Takuo Tsukuda ,  Hiroshi Koyano ,  Atsushi Suda ,  Tadakatsu Hayase ,  Kihito Hada ,  Ken-ichi Kawasaki ,  Susumu Komiyama ,  Naomi Ono ,  Toshikazu Yamazaki ,  Ryoichi Saitoh ,  Masami Kohchi ,  Kiyoshi Hasegawa

发明人： Nobuo Shimma ,  Takuo Tsukuda ,  Hiroshi Koyano ,  Atsushi Suda ,  Tadakatsu Hayase ,  Kihito Hada ,  Ken-ichi Kawasaki ,  Susumu Komiyama ,  Naomi Ono ,  Toshikazu Yamazaki ,  Ryoichi Saitoh ,  Masami Kohchi ,  Kiyoshi Hasegawa

IPC分类号： A61K31/519 ,  C07D513/04 ,  A61P35/00 ,  A61K31/5377

CPC分类号： C07D497/08 ,  C07D513/08 ,  C07D513/18 ,  C07D513/20

摘要： The present invention provides a novel class of compounds that have the activity of inhibiting HSP90 enzyme and are useful as anti-cancer agents or such, and compounds that are useful as synthetic intermediates thereof. Specifically, the present invention provides compounds represented by the following formula (1), and pharmaceutically acceptable salts thereof: wherein X, R1, R2, R3, R4, R5, R6, R7, L1, L2, and L3 are as defined in the specification.

摘要翻译： 本发明提供具有抑制HSP90酶的活性的新型化合物，可用作抗癌剂等，以及可用作其合成中间体的化合物。 具体而言，本发明提供下述式（1）表示的化合物及其药学上可接受的盐：其中X，R1，R2，R3，R4，R5，R6，R7，L1，L2和L3如 规范。

公开(公告)号：US08691061B2

公开(公告)日：2014-04-08

申请号：US13311237

申请日：2011-12-05

申请人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Tomokazu Matsue

发明人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Tomokazu Matsue

IPC分类号： G01N27/416 ,  G01N27/30 ,  G01N33/487

CPC分类号： G01N27/307 ,  G01N27/403 ,  G01N33/487

摘要： An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet with the electrode members piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to an analyte, the other ends located on the bottom surface side of the insulation sheet being connected to an electrodes of a transducer.

摘要翻译： 一种用于电化学传感器芯片的电极装置包括具有绝缘性并且包括在厚度方向上彼此相对的顶表面和底表面的绝缘片，以及具有导电性并由绝缘片保持的电极构件的电极构件 在绝缘片的厚度方向上刺穿绝缘片，绝缘片的顶面侧的电极构件的一端与分析物连接，位于绝缘片的底面侧的另一端与电极 传感器。

公开(公告)号：US20120160678A1

公开(公告)日：2012-06-28

申请号：US13311255

申请日：2011-12-05

申请人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Kosuke Ino ,  Tomokazu Matsue

发明人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Kosuke Ino ,  Tomokazu Matsue

IPC分类号： G01N27/30

CPC分类号： G01N27/3272

摘要： An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet in portions piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to the analyte, other ends located on the bottom surface side of the insulation sheet being connected to the electrodes of the transducer, recesses for trapping the analyte being formed in the top surface of the insulation sheet so as to correspond to the electrode members, the one ends of the electrode members being exposed at a bottom of the recesses.

摘要翻译： 一种用于电化学传感器芯片的电极装置，包括具有绝缘性并且在厚度方向上彼此相对的顶表面和底表面的绝缘片，以及具有导电性的电极构件，并且被绝缘片保持部分刺穿 在绝缘片的厚度方向上，位于绝缘片的上表面侧的电极构件的一端与分析物连接，位于绝缘片的底面侧的另一端与换能器的电极连接， 用于将形成在绝缘片的顶表面中的分析物捕获以与电极构件对应的凹部，电极构件的一端露出在凹部的底部。

公开(公告)号：US20120160676A1

公开(公告)日：2012-06-28

申请号：US13311237

申请日：2011-12-05

申请人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Tomokazu Matsue

发明人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Tomokazu Matsue

IPC分类号： G01N27/26

CPC分类号： G01N27/307 ,  G01N27/403 ,  G01N33/487

摘要： An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet with the electrode members piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to an analyte, the other ends located on the bottom surface side of the insulation sheet being connected to an electrodes of a transducer.

摘要翻译： 一种用于电化学传感器芯片的电极装置包括具有绝缘性并且包括在厚度方向上彼此相对的顶表面和底表面的绝缘片，以及具有导电性并由绝缘片保持的电极构件的电极构件 在绝缘片的厚度方向上刺穿绝缘片，绝缘片的顶面侧的电极构件的一端与分析物连接，位于绝缘片的底面侧的另一端与电极 传感器。

公开(公告)号：US20070123493A1

公开(公告)日：2007-05-31

申请号：US10584233

申请日：2004-12-27

申请人： Hiroshi Koyano ,  Atsushi Suda ,  Kousuke Aso ,  Kihito Hada ,  Miyuki Asai ,  Masami Hasegawa ,  Yasuko Sato

发明人： Hiroshi Koyano ,  Atsushi Suda ,  Kousuke Aso ,  Kihito Hada ,  Miyuki Asai ,  Masami Hasegawa ,  Yasuko Sato

IPC分类号： A61K31/675 ,  A61K31/44 ,  A61K31/277 ,  A61K31/165 ,  C07F9/58

CPC分类号： C07C323/62 ,  C07C233/66 ,  C07C235/46 ,  C07C235/48 ,  C07C235/54 ,  C07C235/64 ,  C07C237/22 ,  C07C237/40 ,  C07C243/38 ,  C07C255/29 ,  C07C255/57 ,  C07C259/10 ,  C07C309/65 ,  C07C323/42 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/08 ,  C07D213/40 ,  C07D213/56 ,  C07D213/75 ,  C07D215/38 ,  C07D233/64 ,  C07D249/08 ,  C07D277/82 ,  C07D295/155 ,  C07D295/32 ,  C07D307/14 ,  C07D307/52 ,  C07D319/08 ,  C07D333/36

摘要： To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for producing the compounds, intermediate compounds useful for their production, and pharmaceutical compositions containing these compounds. The present invention provides compounds of formula (II), or prodrugs thereof, or pharmaceutically acceptable salts of the compounds or the prodrugs, and pharmaceuticals, and pharmaceutical compositions containing these compounds: where A1 is C—X1 or N; Q1 is —A2═A3—, or a heteroatom selected from —O—, —S—, and —N(R10)—; Q2 is —A4═A5—, or a heteroatom selected from —O—, —S—, and —N(R10)—; provided that Q1 and Q2 are not heteroatoms at the same time; A2 is C—X2 or N, A3 is C—X3 or N, A4 is C—X4 or N, and A5 is C—X5 or N; Y is C1-6alkyl, C3-9cycloalkyl, C2-7alkenyl, C2-7alkynyl, C1-6alkoxy, C2-7alkenyloxy, C2-7alkynyloxy, or C1-6alkylthio; Z is a hydrogen atom, hydroxy, C1-6alkyl, C3-9cycloalkyl, or —NR1R2; and L is selected from the formula:

摘要翻译： 提供具有高血管生成抑制活性的化合物，并且可用作有效治疗和预防涉及病理血管发生的疾病，例如癌症和癌症转移的药物，用于制备化合物的方法，可用于其制备的中间体化合物和药物组合物 含有这些化合物。 本发明提供式（II）化合物或其前药或化合物或前药的药学上可接受的盐，以及药物，以及含有这些化合物的药物组合物：其中A 1是CX _{1 或N; Q 1是-N 2 - ，N 3 - 或选自-O - ， - S - 和-N（R - ; Q 2是 - 或者选自-O - ， - S - 和-N（R（R））的杂原子， - ; 条件是Q 1和Q 2同时不是杂原子; A 2是N 2，或N 3是N 3，或N，A 4， / SUB>是CX 4或N，A 5是CX 5或N; Y是C 1-6烷基，C 3-9环烷基，C 2-7链烯基，C 2-7环烷基， C 1-6烷基，C 2-7链烯氧基，C 2-7炔氧基或C 1〜 6烷硫基; Z是氢原子，羟基，C 1-6烷基，C 3-9环烷基或-NR 1 R 2 L选自下式：}

公开(公告)号：US06850584B2

公开(公告)日：2005-02-01

申请号：US09729949

申请日：2000-12-06

申请人： Kazuhisa Kogure ,  Hiroshi Yamada ,  Atsushi Suda

发明人： Kazuhisa Kogure ,  Hiroshi Yamada ,  Atsushi Suda

IPC分类号： H03L7/113 ,  H03L7/087 ,  H04B10/07 ,  H04B10/40 ,  H04B10/50 ,  H04B10/524 ,  H04B10/556 ,  H04B10/60 ,  H04B10/69 ,  H04J14/00 ,  H04J14/02 ,  H04L7/027 ,  H04L7/033 ,  H03D3/24

CPC分类号： H03L7/087 ,  H04B10/6932 ,  H04L7/027 ,  H04L7/033

摘要： A clock regeneration circuit having a PLL circuit which includes a voltage control oscillator; a clock extraction circuit which includes a band passing filter and a harmonic component of a dividing signal of the oscillation frequency signal; a frequency detector; a filter; a bit rate detection circuit; and a frequency selection circuit outputting an oscillation frequency of the voltage control oscillator of the PLL circuit or a frequency signal obtained by dividing the oscillation frequency in response to the bit rate detected by the bit rate detection circuit, as a regeneration clock circuit.

摘要翻译： 一种具有PLL电路的时钟再生电路，包括电压控制振荡器; 时钟提取电路，其包括带通滤波器和所述振荡频率信号的分频信号的谐波分量; 频率检测器; 过滤器 比特率检测电路; 以及频率选择电路，其输出PLL电路的压控振荡器的振荡频率或者通过将比特率检测电路检测到的比特率除以振荡频率而获得的频率信号作为再生时钟电路。

公开(公告)号：US08675200B2

公开(公告)日：2014-03-18

申请号：US13384226

申请日：2010-09-01

申请人： Atsushi Suda ,  Jean-Jacques Delaunay ,  Etsuo Maeda ,  Ichiro Yamada

发明人： Atsushi Suda ,  Jean-Jacques Delaunay ,  Etsuo Maeda ,  Ichiro Yamada

IPC分类号： G01J4/00 ,  G01N21/25 ,  G01N21/27 ,  G01N21/55

CPC分类号： G01N21/554

摘要： Light from light source means (a wavelength-variable laser) is applied to a surface of a hydrogen absorbing thin metal film of a hydrogen detecting surface plasmon resonator including a surface plasmon resonance enhancement structure formed by providing in the thin film an array of periodic holes having a shape that is not 90-degree rotational symmetric in the plane of the film surface, and transmitted light is detected with light detecting means (a photometer). Hydrogen is detected on the basis of a change in light transmission frequency characteristic caused by hydrogen absorption in the hydrogen detecting surface plasmon resonator. Optical hydrogen detection that is highly safe and unaffected by variations in the amount of light from the light source and stray light can be achieved.

摘要翻译： 来自光源的光（波长可变激光）被施加到氢检测表面等离子体激元谐振器的吸氢金属薄膜的表面，该表面等离子体激元包括通过在薄膜中提供周期性孔阵列而形成的表面等离子体共振增强结构 具有在膜表面的平面上不是90度旋转对称的形状，并且用光检测装置（光度计）检测透射光。 基于由氢检测表面等离子体激元谐振器中的氢吸收引起的光透射频率特性的变化来检测氢。 可以实现高度安全且不受来自光源和杂散光的光的变化的光学氢检测。

公开(公告)号：US08470144B2

公开(公告)日：2013-06-25

申请号：US13311255

申请日：2011-12-05

申请人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Kosuke Ino ,  Tomokazu Matsue

发明人： Atsushi Suda ,  Tatsuo Kimura ,  Ryota Kunikata ,  Kosuke Ino ,  Tomokazu Matsue

IPC分类号： G01N27/416

CPC分类号： G01N27/3272

摘要： An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet in portions piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to the analyte, other ends located on the bottom surface side of the insulation sheet being connected to the electrodes of the transducer, recesses for trapping the analyte being formed in the top surface of the insulation sheet so as to correspond to the electrode members, the one ends of the electrode members being exposed at a bottom of the recesses.

摘要翻译： 一种用于电化学传感器芯片的电极装置，包括具有绝缘性并且在厚度方向上彼此相对的顶表面和底表面的绝缘片，以及具有导电性的电极构件，并且被绝缘片保持部分刺穿 在绝缘片的厚度方向上，位于绝缘片的上表面侧的电极构件的一端与分析物连接，位于绝缘片的底面侧的另一端与换能器的电极连接， 用于将形成在绝缘片的顶表面中的分析物捕获以与电极构件对应的凹部，电极构件的一端露出在凹部的底部。

公开(公告)号：US08063046B2

公开(公告)日：2011-11-22

申请号：US12730093

申请日：2010-03-23

申请人： Hiroshi Koyano ,  Atsushi Suda ,  Kousuke Aso ,  Kihito Hada ,  Miyuki Asai ,  Masami Hasegawa ,  Yasuko Sato

发明人： Hiroshi Koyano ,  Atsushi Suda ,  Kousuke Aso ,  Kihito Hada ,  Miyuki Asai ,  Masami Hasegawa ,  Yasuko Sato

IPC分类号： A61K31/435 ,  A61K31/415 ,  A61K31/40 ,  A61K31/34 ,  A61K31/17 ,  C07D213/00 ,  C07D233/00 ,  C07D209/00 ,  C07D307/00 ,  C07C239/00

CPC分类号： C07C323/62 ,  C07C233/66 ,  C07C235/46 ,  C07C235/48 ,  C07C235/54 ,  C07C235/64 ,  C07C237/22 ,  C07C237/40 ,  C07C243/38 ,  C07C255/29 ,  C07C255/57 ,  C07C259/10 ,  C07C309/65 ,  C07C323/42 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/08 ,  C07D213/40 ,  C07D213/56 ,  C07D213/75 ,  C07D215/38 ,  C07D233/64 ,  C07D249/08 ,  C07D277/82 ,  C07D295/155 ,  C07D295/32 ,  C07D307/14 ,  C07D307/52 ,  C07D319/08 ,  C07D333/36

摘要： Compounds having high angiogenesis inhibiting activity useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, e.g. cancer and cancer metastasis, are of formula (II), where A1 is C—X1 or N; Q1 is -A2=A3-, or a heteroatom selected from —O—, —S—, and —N(R10)—; Q2 is -A4=A5-, or a heteroatom selected from —O—, —S—, and —N(R10)—; provided that Q1 and Q2 are not heteroatoms at the same time; A2 is C—X2 or N, A3 is C—X3 or N, A4 is C—X4 or N, and A5 is C—X5 or N; Y is C1-6alkyl, C3-9cycloalkyl, C2-7alkenyl, C2-7alkynyl, C1-6alkoxy, C2-7alkenyloxy, C2-7alkynyloxy, or C1-6alkylthio; Z is a hydrogen atom, hydroxy, C1-6alkyl, C3-9 cycloalkyl, or —NR1R2; and L is selected from the formula:

摘要翻译： 具有高血管生成抑制活性的化合物可用作有效治疗和预防涉及病理性血管发生的疾病的药剂，例如， 癌症和癌症转移，具有式（II），其中A1是C-X1或N; Q1是-A2 = A3-或选自-O - ， - S - 和-N（R10） - 的杂原子。 Q2是-A4 = A5-或选自-O - ， - S - 和-N（R10） - 的杂原子。 条件是Q1和Q2不是同时的杂原子; A2是C-X2或N，A3是C-X3或N，A4是C-X4或N，A5是C-X5或N; Y是C 1-6烷基，C 3-9环烷基，C 2-7烯基，C 2-7炔基，C 1-6烷氧基，C 2-7烯醇基氧基，C 2-7炔基氧基或C 1-6烷硫基; Z是氢原子，羟基，C 1-6烷基，C 3-9环烷基或-NR 1 R 2; L选自下式：