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公开(公告)号：US20100233172A1
公开(公告)日：2010-09-16
申请号：US12639083
申请日：2009-12-16
申请人： Roberto Weinmann , Rameh Hafezi , Arthur M.P. Doweyko , Ashok Ramesh Dongre , Deborah L. Roussell , Robert F. Carney
发明人： Roberto Weinmann , Rameh Hafezi , Arthur M.P. Doweyko , Ashok Ramesh Dongre , Deborah L. Roussell , Robert F. Carney
IPC分类号： A61K39/395 , A61P35/00 , A61K31/713 , A61K38/16 , A61K31/5513 , G01N33/567 , G01N33/573 , C12N5/09 , G01N33/53
CPC分类号： A61K31/551 , A61K31/00 , A61K31/7088 , G01N33/5011 , G01N33/502 , G01N2510/00
摘要： Improved compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders, and methods of screening to identify compounds for such treatments.
摘要翻译： 公开了改进的组合物和方法，其可用于治疗和预防增殖性疾病，以及筛选以鉴定用于此类治疗的化合物的方法。
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2.发明申请BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS 审中-公开生物标记物和测定敏感性的方法，用于生物生长因子受体调节剂公开(公告)号：US20110269139A1
公开(公告)日：2011-11-03
申请号：US13143228
申请日：2010-01-06
IPC分类号： C12Q1/68 , C12Q1/02 , G01N21/64 , G01N33/559 , G01N30/02 , G01N21/55 , G01N27/26 , G01N33/566 , H01J49/26
CPC分类号： G01N33/57484 , G01N33/6872 , G01N2333/485
摘要： The present invention provides methods useful for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, and diagnostic methods and kits thereof.
摘要翻译： 本发明提供了可用于预测将对治疗癌症的治疗方法进行治疗的哺乳动物的可能性的方法，包括施用EGFR调节剂及其诊断方法和试剂盒。
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3.发明申请BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO INSULIN GROWTH FACTOR-1 RECEPTOR MODULATORS 有权生物标记物和确定胰岛素生长因子-1受体调节剂敏感性的方法公开(公告)号：US20100184125A1
公开(公告)日：2010-07-22
申请号：US12600504
申请日：2008-05-15
申请人： Fei Huang , Xia Han , Rameh Hafezi , Jiwen Chen , Douglas Michael Robinson , Gayle M. Wittenberg , Ashok Ramesh Dongre , Joan M. Carboni , Ricardo M. Attar , Warren Hurlburt , Marco M. Gottardis
发明人： Fei Huang , Xia Han , Rameh Hafezi , Jiwen Chen , Douglas Michael Robinson , Gayle M. Wittenberg , Ashok Ramesh Dongre , Joan M. Carboni , Ricardo M. Attar , Warren Hurlburt , Marco M. Gottardis
IPC分类号： C12Q1/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer.
摘要翻译： IGF1R生物标志物可用于鉴定和监测将对治疗癌症治疗的治疗反应的哺乳动物的方法，其包括施用IGF1R调节剂，其中所述方法包括（a）将哺乳动物暴露于IGF1R调节剂和（b）在哺乳动物中测量 所述至少一种生物标志物的水平，其中在（b）中测量的至少一种生物标志物的水平的差异与尚未暴露于IGF1R调节剂的哺乳动物中的生物标志物的水平相比表明哺乳动物将 对治疗癌症的方法进行反应和（c）其中暴露于IGF1R调节剂后哺乳动物中生物标志物的水平表明哺乳动物对治疗癌症的方法具有反应。
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4.发明授权Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators 有权用于确定对胰岛素生长因子-1受体调节剂敏感性的生物标志物和方法公开(公告)号：US08492328B2
公开(公告)日：2013-07-23
申请号：US12600504
申请日：2008-05-15
申请人： Fei Huang , Xia Han , Rameh Hafezi , Jiwen Chen , Douglas Michael Robinson , Gayle M. Wittenberg , Ashok Ramesh Dongre , Joan M. Carboni , Ricardo M. Attar , Warren Hurlburt , Marco M. Gottardis
发明人： Fei Huang , Xia Han , Rameh Hafezi , Jiwen Chen , Douglas Michael Robinson , Gayle M. Wittenberg , Ashok Ramesh Dongre , Joan M. Carboni , Ricardo M. Attar , Warren Hurlburt , Marco M. Gottardis
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer.
摘要翻译： IGF1R生物标志物可用于鉴定和监测将对治疗癌症治疗的治疗反应的哺乳动物的方法，其包括施用IGF1R调节剂，其中所述方法包括（a）将哺乳动物暴露于IGF1R调节剂和（b）在哺乳动物中测量 所述至少一种生物标志物的水平，其中在（b）中测量的至少一种生物标志物的水平的差异与尚未暴露于IGF1R调节剂的哺乳动物中的生物标志物的水平相比表明哺乳动物将 对治疗癌症的方法进行反应和（c）其中暴露于IGF1R调节剂后哺乳动物中生物标志物的水平表明哺乳动物对治疗癌症的方法具有反应。
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