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    COUPLING DEVICE AND USE THEREOF
    1.
    发明申请
    COUPLING DEVICE AND USE THEREOF 有权
    耦合器件及其使用

    公开(公告)号：US20100292633A1

    公开(公告)日：2010-11-18

    申请号：US12376929

    申请日：2007-08-13

    Applicant: Arduino Arduini ,  Paolo Cerasoli ,  Fabio Arrizza

    Inventor： Arduino Arduini ,  Paolo Cerasoli ,  Fabio Arrizza

    IPC: A61M25/16 ,  A61M25/14 ,  A61M1/28

    CPC classification number: A61M1/28 ,  A61M1/285 ,  A61M39/165 ,  A61M39/223 ,  A61M39/26

    Abstract: A coupling device (1) for the connection of two ends (3, 9) of respective tubular members (2, 5), allowing the contact of the flowing fluid only with elements inside a closed container, circumstances and an inherently easy connection operation, thus it can be carried out, comprising: a closed container (10) housing said ends (3, 9) of respective tubular members (2, 5), one of said tubular members having a flexible terminal section (8) thereof inside said closed container; a mobile connection member (15), coupled at the end of said flexible terminal section (8), having a nozzle (16) apt to be inserted within a receiving end of the other tubular member,—and a cam device, located inside said closed container (10) and apt to be actuated from the outside of said closed container, apt to cooperate with said mobile connection member (15), the cam device causing the insertion and the ejection of said nozzle in and from said receiving end, and the corresponding connection and the disconnection of the two ends.

    Abstract translation: 一种用于连接相应管状构件（2,5）的两端（3,9）的联接装置（1），允许流动流体仅与密闭容器内的元件接触，环境和固有简单的连接操作， 因此可以进行，其包括：容纳相应管状构件（2,5）的所述端部（3,9）的密闭容器（10），所述管状构件中的一个在其内部具有柔性端子部分（8） 容器; 耦合在所述柔性端子部分（8）的端部处的移动连接构件（15）具有易于插入到另一管状构件的接收端内的喷嘴（16），以及位于所述柔性端子部分 密封容器（10），并且易于从所述密闭容器的外部致动，易于与所述可移动连接构件（15）配合，所述凸轮装置使所述喷嘴插入所述接收端和从所述接收端排出;以及 相应的连接和两端的断开。

    STORAGE AND MAINTENANCE OF BLOOD PRODUCTS INCLUDING RED BLOOD CELLS AND PLATELETS
    3.
    发明申请
    STORAGE AND MAINTENANCE OF BLOOD PRODUCTS INCLUDING RED BLOOD CELLS AND PLATELETS 失效
    包括红血细胞和血小板的血液制品的储存和维护

    公开(公告)号：US20070248941A1

    公开(公告)日：2007-10-25

    申请号：US11770136

    申请日：2007-06-28

    Applicant: Secondo DOTTORI ,  Arduino Arduini

    Inventor： Secondo DOTTORI ,  Arduino Arduini

    IPC: A01N1/02 ,  B01L3/00 ,  B65D17/00

    CPC classification number: A61L2/0058 ,  A01N1/0215 ,  A01N1/0226 ,  A01N1/0294 ,  A61L2/0035 ,  A61L2/0047 ,  A61L2202/22

    Abstract: Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transhision to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.

    Abstract translation: 通过加入1mM-10mM左旋肉碱及其衍生物来改善红细胞和血小板浓缩物的细胞膜维持。 这种改善使得包装的红血细胞和血小板浓度的生存期延长超过当前时期。 此外，如此处理的材料在对患者进行转换时表现出延长的循环半衰期。 通过该方法实现的膜维持改进允许照射血液制品的密封容器，从而基本上消毒和破坏其中的白细胞。

    Carnitine-Containing Peritoneal Dialysis Solution Having Improved Biocompatibility
    5.
    发明申请
    Carnitine-Containing Peritoneal Dialysis Solution Having Improved Biocompatibility 审中-公开
    含肉碱的腹膜透析液具有改善的生物相容性

    公开(公告)号：US20080138443A1

    公开(公告)日：2008-06-12

    申请号：US11815356

    申请日：2006-02-22

    Applicant: Arduino Arduini

    Inventor： Arduino Arduini

    IPC: A61K33/20 ,  A61K31/14 ,  A61K31/7004 ,  A61K31/715

    CPC classification number: A61K45/06 ,  A61K31/14 ,  A61K31/195 ,  A61K31/35 ,  A61K31/7004 ,  A61K31/715 ,  A61K33/20 ,  A61K2300/00

    Abstract: The protective effect on peritoneum of L-carnitine and its lower alkanoyl derivatives, both in the form of inner or pharmaceutically acceptable salts is disclosed. Concentrations of carnitine from about 0.02 to 0.5% w/v are suitable for preparing a solution for peritoneal dialysis having higher biocompatibility and protecting peritoneum from toxic effects of continuous use of solutions for peritoneal dialysis, in particular ones containing glucose as osmotic agent. A particularly preferred embodiment is a solution for peritoneal dialysis containing carnitine, glucose and xylitol.

    Abstract translation: 公开了以内酯或药学上可接受的盐的形式对L-肉毒碱及其低级烷酰基衍生物的腹膜的保护作用。 肉碱的浓度约0.02-0.5％w / v适用于制备具有较高生物相容性的腹膜透析溶液，并保护腹膜免受连续使用腹膜透析溶液的毒性作用，特别是含有葡萄糖作为渗透剂的溶液。 特别优选的实施方案是含有肉碱，葡萄糖和木糖醇的腹膜透析溶液。

    Coupling device
    8.
    发明授权
    Coupling device 有权
    耦合装置

    公开(公告)号：US08992508B2

    公开(公告)日：2015-03-31

    申请号：US12681257

    申请日：2008-10-02

    Applicant: Arduino Arduini ,  Paolo Cerasoli ,  Fabio Arrizza

    Inventor： Arduino Arduini ,  Paolo Cerasoli ,  Fabio Arrizza

    IPC: A61M39/00 ,  A61M39/10

    CPC classification number: A61M39/10 ,  A61M39/1011 ,  A61M2039/1027 ,  A61M2039/1083

    Abstract: A coupling device for connecting two ends of respective tubular members, allow the opening and the closing of a first tubular member and the simultaneous engagement of the two tubular members, as to prevent pollution, includes: a first case housing a first end of a respective first tubular member, comprising closing means of said first end; a second case, wherein a flexible terminal section of a respective second tubular member is received, comprising means for driving a second end of said second tubular member from a retracted position to a engagement position into said first end and vice versa; and means for reversibly connecting said first and second cases at a respective coupling port thereof, defining a single sealed environment; wherein the engagement and the disengagement of said second end and the automatic mechanical activation and deactivation of said closing means for opening and closing said first end.

    Abstract translation: 用于连接各个管状构件的两端的连接装置允许第一管状构件的打开和关闭以及两个管状构件同时接合以防止污染，包括：第一壳体，其容纳相应的管状构件的第一端 第一管状构件，包括所述第一端的封闭装置; 第二壳体，其中容纳相应的第二管状构件的柔性端子部分，包括用于将所述第二管状构件的第二端从缩回位置驱动到接合位置进入所述第一端的装置，反之亦然; 以及用于在限定单个密封环境的相应联接口处可逆地连接所述第一和第二壳体的装置; 其中所述第二端的接合和分离以及用于打开和关闭所述第一端的所述关闭装置的自动机械启动和停用。

    Method for inhibiting bacterial growth in a leuko-reduced platelet concentrate by adding L-carnitine
    9.
    发明授权
    Method for inhibiting bacterial growth in a leuko-reduced platelet concentrate by adding L-carnitine 失效
    通过加入左旋肉碱来抑制白细胞减少的血小板浓缩物中的细菌生长的方法

    公开(公告)号：US07816073B2

    公开(公告)日：2010-10-19

    申请号：US10756368

    申请日：2004-01-14

    Applicant: Secondo Dottori ,  Arduino Arduini

    Inventor： Secondo Dottori ,  Arduino Arduini

    IPC: A01N1/02

    CPC classification number: A61L2/0058 ,  A01N1/0215 ,  A01N1/0226 ,  A01N1/0294 ,  A61L2/0035 ,  A61L2/0047 ,  A61L2202/22

    Abstract: Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same.

    Abstract translation: 通过加入1mM-10mM左旋肉碱及其衍生物来改善红细胞和血小板浓缩物的细胞膜维持。 这种改善使得包装的红血细胞和血小板浓度的生存期延长超过当前时期。 此外，如此处理的材料在输血时显示延长的循环半衰期。 通过该方法实现的膜维持改进允许照射血液制品的密封容器，从而基本上消毒和破坏其中的白细胞。

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