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公开(公告)号：US09247766B2
公开(公告)日：2016-02-02
申请号：US12992530
申请日：2009-05-14
申请人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman , Andrew Brown
发明人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman , Andrew Brown
CPC分类号： A23L1/3053 , A23J1/20 , A23L33/18 , A23L33/19 , A61K38/00 , C07K14/515
摘要： The invention provides methods for enriching a milk extract for angiogenin, such methods involving separation by size, charge or immunoaffinity. The invention also provides the angiogenin enriched extract produced by the methods and provides them in pharmaceutical and neutraceutical compositions and foods for treating a variety of diseases or disorders that can be treated by angiogenin.
摘要翻译： 本发明提供了用于富集血管生成素的乳提取物的方法，所述方法涉及通过大小，电荷或免疫亲和力分离。 本发明还提供了通过该方法产生的血管生成素富集的提取物，并将其提供于药物和营养组合物以及用于治疗可被血管生成素治疗的多种疾病或病症的食物。
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公开(公告)号：US20130039889A1
公开(公告)日：2013-02-14
申请号：US13510172
申请日：2011-11-18
CPC分类号： C07K14/4703 , C07K14/515
摘要： The invention relates to a recombinant microorganism comprising a transgene encoding angiogenin and optionally follistatin, a food product, beverage product or animal feed produced from or comprising said microorganism and uses thereof.
摘要翻译： 本发明涉及包含编码血管生成素和任选的卵泡抑素的转基因的重组微生物，由所述微生物产生或包含所述微生物的食品，饮料产品或动物饲料及其用途。
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公开(公告)号：US20120331575A1
公开(公告)日：2012-12-27
申请号：US13510171
申请日：2010-11-18
申请人： Peter Hobman , Matthew McDonagh , Benjamin Cocks , Angus Tester
发明人： Peter Hobman , Matthew McDonagh , Benjamin Cocks , Angus Tester
IPC分类号： A01K67/027 , A61K38/19 , A61P21/00 , A61P19/10 , A61P19/08 , A23L1/32 , A61P29/00 , A61P3/06 , A61D19/04 , A23C9/00 , A23L1/31 , C12N15/85 , A61P25/00
CPC分类号： A61K35/20 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/101 , A01K2227/105 , A01K2267/01 , A23C2230/05 , A61K38/00 , C07K14/515 , C12N15/8509 , A61K2300/00
摘要： The invention provides a non-human transgenic animal comprising a transgene encoding angiogenin and food products comprising or obtained from the non-human transgenic animal and uses thereof.
摘要翻译： 本发明提供一种非人转基因动物，其包含编码血管生成素的转基因和包含非获得性转基因动物及其用途的食品。
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公开(公告)号：US20120328591A1
公开(公告)日：2012-12-27
申请号：US13510167
申请日：2010-11-18
CPC分类号： C07K14/515 , A61K38/00 , A61K47/64
摘要： The invention provides a method of improving the oral delivery of a therapeutic agent, comprising the step of linking the therapeutic agent to a carrier protein comprising angiogenin, fusion proteins or conjugates comprising angiogenin and a therapeutic agent and their use in medicine.
摘要翻译： 本发明提供了一种改善治疗剂的口服递送的方法，包括将治疗剂与包含血管生成素，融合蛋白或包含血管生成素和治疗剂的缀合物的载体蛋白质连接的方法及其在药物中的用途。
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公开(公告)号：US20100136172A1
公开(公告)日：2010-06-03
申请号：US12447889
申请日：2007-11-09
申请人： Andrew Brown , Michelle Rowney , Peter Hobman , Matthew McDonagh , Angus Tester , Benjamin Cocks
发明人： Andrew Brown , Michelle Rowney , Peter Hobman , Matthew McDonagh , Angus Tester , Benjamin Cocks
IPC分类号： A23C9/146
摘要： The invention provides a process for the preparation of an angiogenin-enriched fraction from a milk product, the process comprising contacting the milk product with a cation exchange resin and eluting the angiogenin-enriched fraction from the cation exchange resin with a mobile phase. The invention also provides angiogenin-enriched fractions produced by process and food products, neutraceuticals and pharmaceutical comprising such angiogenin.
摘要翻译： 本发明提供了一种从乳制品制备富含血管生成素的级分的方法，该方法包括使乳制品与阳离子交换树脂接触，并用流动相从阳离子交换树脂中洗脱含血管生成素的部分。 本发明还提供了通过方法和食品产生的血管生成素富集级分，包含这种血管生成素的中性药物和药物。
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6.发明授权Use of angiogenin or angiogenin agonists for treating diseases and disorders 有权使用血管生成素或血管生成素激动剂治疗疾病和病症公开(公告)号：US09119818B2
公开(公告)日：2015-09-01
申请号：US12992501
申请日：2009-05-14
申请人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
发明人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
CPC分类号： A61K38/465 , A23K20/142 , A23L33/19 , A61K9/0053 , A61K35/20 , A61K38/1709 , A61K38/1891 , C12Y301/27 , A61K2300/00
摘要： The invention provides a method of treating a disorder characterized by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuroprotection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided.
摘要翻译： 本发明提供了一种治疗以升高或失调的肌生长抑制素为特征的疾病的方法，其中卵泡抑素和血管生成素之间的相互作用可用于改善组织，神经系统疾病或病症，脊髓损伤或疾病，骨疾病或病症中涉及的疾病， 葡萄糖体内平衡，伤口愈合，神经保护，神经系统功能支持或代谢疾病的治疗，所述方法包括施用有效量的血管生成素或血管生成素激动剂。 还提供了包含血管生成素的组合物和营养物质。
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7.发明申请USE OF ANGIOGENIN OR ANGIOGENIN AGONISTS FOR TREATING DISEASES AND DISORDERS 有权用于治疗疾病和疾病的血管生成素或神经氨酸激素的使用公开(公告)号：US20110151016A1
公开(公告)日：2011-06-23
申请号：US12992501
申请日：2009-05-14
申请人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
发明人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
IPC分类号： A61K35/20 , A61K38/14 , A61P21/00 , A61P3/04 , A61P25/00 , A61P19/00 , A61P3/00 , A61P3/08 , A61P17/02 , A61P19/02 , A61P3/02 , A61P3/10
CPC分类号： A61K38/465 , A23K20/142 , A23L33/19 , A61K9/0053 , A61K35/20 , A61K38/1709 , A61K38/1891 , C12Y301/27 , A61K2300/00
摘要： The invention provides a method of treating a disorder characterised by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuro-protection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided.
摘要翻译： 本发明提供了一种治疗以升高或失调的肌生长抑制素为特征的疾病的方法，其中卵泡抑素和血管生成素之间的相互作用可用于改善组织，神经系统疾病或病症，脊髓损伤或疾病，骨疾病或病症中涉及的疾病， 葡萄糖体内平衡，伤口愈合，神经保护，神经系统功能支持或管理代谢疾病，所述方法包括施用有效量的血管生成素或血管生成素激动剂。 还提供了包含血管生成素的组合物和营养物质。
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公开(公告)号：US08551547B2
公开(公告)日：2013-10-08
申请号：US12447889
申请日：2007-11-09
申请人： Andrew Brown , Michelle Rowney , Peter Hobman , Matthew McDonagh , Angus Tester , Benjamin Cocks
发明人： Andrew Brown , Michelle Rowney , Peter Hobman , Matthew McDonagh , Angus Tester , Benjamin Cocks
摘要： The invention provides a process for the preparation of an angiogenin-enriched fraction from a milk product, the process comprising contacting the milk product with a cation exchange resin and eluting the angiogenin-enriched fraction from the cation exchange resin with a mobile phase. The invention also provides angiogenin-enriched fractions produced by process and food products, nutraceuticals and pharmaceutical comprising such angiogenin.
摘要翻译： 本发明提供了一种从乳制品制备富含血管生成素的级分的方法，该方法包括使乳制品与阳离子交换树脂接触，并用流动相从阳离子交换树脂中洗脱含血管生成素的部分。 本发明还提供由方法和食品，营养药物和包含这种血管生成素的药物产生的富含血管生成素的级分。
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9.发明申请ORALLY ADMINISTRABLE DOSAGE FORMS COMPRISING ANGIOGENIN AND USES THEREOF 审中-公开含有血管生成素的ORALY管理剂型及其用途公开(公告)号：US20110262422A1
公开(公告)日：2011-10-27
申请号：US12992416
申请日：2009-05-14
申请人： Benjamin Cocks , Angus Tester , Peter Hobman , Matthew McDonagh
发明人： Benjamin Cocks , Angus Tester , Peter Hobman , Matthew McDonagh
IPC分类号： A61K38/46 , A61P3/00 , A61P3/10 , A61P3/04 , A61P11/00 , A61P19/10 , A61P19/02 , A61P19/08 , C12N9/22 , A61P21/00
CPC分类号： A61K38/1891 , A61K38/1709 , A61K2300/00
摘要： The invention provides a method of treatment of any disorder in which administration of angiogenin is beneficial wherein the angiogenin is administered orally. Particularly, the oral angiogenin does not require a carrier or excipient or for the protein to be encapsulated or subjected to any other mechanism to improve its oral bioavailability.
摘要翻译： 本发明提供治疗其中血管生成素的施用是有益的任何病症的方法，其中血管生成素被口服给药。 特别地，口服血管生成素不需要载体或赋形剂或蛋白质被包封或经受任何其它机制来改善其口服生物利用度。
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公开(公告)号：US20110123514A1
公开(公告)日：2011-05-26
申请号：US12992530
申请日：2009-05-14
申请人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman , Andrew Brown
发明人： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman , Andrew Brown
CPC分类号： A23L1/3053 , A23J1/20 , A23L33/18 , A23L33/19 , A61K38/00 , C07K14/515
摘要： The invention provides methods for enriching a milk extract for angiogenin, such methods involving separation by size, charge or immunoaffinity. The invention also provides the angiogenin enriched extract produced by the methods and provides them in pharmaceutical and neutraceutical compositions and foods for treating a variety of diseases or disorders that can be treated by angiogenin.
摘要翻译： 本发明提供了用于富集血管生成素的乳提取物的方法，所述方法涉及通过大小，电荷或免疫亲和力分离。 本发明还提供了通过该方法产生的血管生成素富集的提取物，并将其提供于药物和营养组合物以及用于治疗可被血管生成素治疗的多种疾病或病症的食物。
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