公开(公告)号：US07589208B2

公开(公告)日：2009-09-15

申请号：US11050441

申请日：2005-02-04

申请人： Karl Jansson ,  Tomas Fristedt ,  Hans Wännman ,  Anders Björk

发明人： Karl Jansson ,  Tomas Fristedt ,  Hans Wännman ,  Anders Björk

IPC分类号： C07D215/38

CPC分类号： A61K31/47 ,  A61K9/1617 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/4706

摘要： A stable solid pharmaceutical composition consisting essentially of an effective amount of a salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

摘要翻译： 一种稳定的固体药物组合物，其基本上由有效量的式（II）的盐与保持pH优选高于8的碱反应组分或与二价金属阳离子的盐组成; 和至少一种药物赋形剂; 所述式（II）的盐在室温下储存至少3年的时间基本上是稳定的。 稳定式（II）的盐的方法。 式（II）的结晶盐和制备所述盐的方法。

公开(公告)号：US20080109266A1

公开(公告)日：2008-05-08

申请号：US10556347

申请日：2004-05-12

申请人： Anders Björk ,  Susanne Granz

发明人： Anders Björk ,  Susanne Granz

IPC分类号： G06Q10/00 ,  A01J5/017

CPC分类号： A01J5/007 ,  G06Q10/063

摘要： A method includes the steps of recording milk yields (MY?1#191, MY?2#191, MY?N#191) from milkings of an udder quarter or udder of a milking animal; recording the times (t1, t2, . . . , tN) of the milkings; calculating milk secretion rates (MSR1, MSR2, . . . , MSRN) for said udder quarter or udder based on the milk yields and times; fitting a time dependent function (F(t)) to the calculated secretion rates, said time dependent function comprising one portion, which increases with time, and one portion, which decreases with time; estimating an expected milk secretion rate (EMSRt1+N) for said udder quarter or udder at a time (tN+1) following the last milking based on said function (F(t)); determining an expected milk yield (EMYtN+1) for said udder quarter or udder at said time based on the expected secretion rate and, at said time, the time period lapsed since last milking; and initiating an action to be performed with respect to said animal depending on said expected milk yield.

摘要翻译： 一种方法包括从哺乳动物的乳房四分之一或乳房的乳汁中记录乳产量（MY≥1＃191，MY≥2＃191，MY≤N＃191）的步骤; 记录乳汁的时间（t 1> 1，t 2 2，...，t N N N）; 基于牛奶产量计算所述乳房季度或乳房的乳汁分泌率（MSR <1>，MSR 2>，...，MSR N N） 和时代 将时间依赖函数（F（t））拟合到所计算的分泌速率，所述时间依赖函数包括随时间增加的一部分和随时间减少的一部分; 基于所述功能估计在最后一次挤奶之后的时间（t N N + 1），所述乳房四分之一或乳房的预期乳分泌率（EMSR ） F（t））; 基于预期的分泌速率确定所述乳房季度或乳房在所述乳房季度或乳房的预期乳产量（EMYTN + 1N），并且在所述时间，自上次挤奶后经过的时间段; 并根据所述预期的产奶量开始相对于所述动物进行的动作。

公开(公告)号：US07128020B2

公开(公告)日：2006-10-31

申请号：US10491233

申请日：2002-10-10

申请人： Anders Björk ,  Gösta Forsén ,  Bohao Liao

发明人： Anders Björk ,  Gösta Forsén ,  Bohao Liao

IPC分类号： A01J7/04

CPC分类号： A01J7/04

摘要： This invention relates to a device and a method for allowing performance of several separate treatment of a teat of an animal. The device includes a cup-shaped body (1) having a surface (2) defining an inner space (3), which is arranged to receive the teat of the animal. The device also includes a first delivery mechanism arranged to provide a first treatment by supplying a first medium (4) to the teat via at least a first passage having a plurality of openings (10, 18) to the inner space (3) and at least one additional delivery mechanism arranged to provide an additional medium (13, 26, 28) to the teat, via at least an additional passage having a plurality of openings (10,18) to the inner space(3). Thereby, the device provides at least two different treatments of the teats at different occasions.

摘要翻译： 本发明涉及用于允许对动物的乳头进行几次单独处理的装置和方法。 该装置包括具有限定内部空间（3）的表面（2）的杯形体（1），其布置成接收动物的乳头。 该装置还包括第一输送机构，该第一输送机构设置成通过至少一个具有多个开口（10,18）到内部空间（3）的第一通道，并在第二通道 至少一个另外的传送机构，其布置成通过至少一个具有到内部空间（3）的多个开口（10,18）的附加通道，向乳头提供附加介质（13,26,28）。 因此，该装置在不同的场合提供乳头的至少两种不同的处理。

公开(公告)号：US06425345B1

公开(公告)日：2002-07-30

申请号：US09600611

申请日：2000-08-18

申请人： Ole Lind ,  Anders Björk

发明人： Ole Lind ,  Anders Björk

IPC分类号： A01J5007

CPC分类号： A01J5/0175 ,  A01J5/007 ,  A01J5/08

摘要： A method and device for milking an animal by using at least one milking machine (5) including at least one teatcup (3) having a teatcup liner (11) forming a space defined by a wall surface. The teatcup (3) is arranged to be applied to a teat in such a manner that the wall surface extends around and abuts the teat. The device includes a control unit arranged to control the application of the teatcup (3) in such a manner that an arbitrary portion of the wall surface abuts different teat portions during a first milking occasion with respect to an animal and during a later milking occasion with respect to this animal, respectively.

摘要翻译： 一种用于通过使用至少一个挤奶机（5）挤奶动物的方法和装置，所述挤奶机包括至少一个具有形成由壁表面限定的空间的挤奶杯衬套（11）的奶杯（3）。 乳头杯（3）被布置成以这样的方式施加到奶头，使得壁表面围绕并邻接奶头。 该装置包括控制单元，该控制单元被布置成以这样一种方式控制奶杯（3）的应用，使得壁表面的任意部分在关于动物的第一挤奶时间期间与不同的奶头部分相邻，并且在随后的挤奶期间， 分别尊重这种动物。

公开(公告)号：US06395750B1

公开(公告)日：2002-05-28

申请号：US09694757

申请日：2000-10-24

申请人： Gunnar Hedlund ,  Karl Jansson ,  Stig Jönsson ,  Anders Björk

发明人： Gunnar Hedlund ,  Karl Jansson ,  Stig Jönsson ,  Anders Björk

IPC分类号： A61K3147

CPC分类号： A61K31/47 ,  C07D215/54 ,  C07D215/56

摘要： The invention relates to a method for the treatment of tumors in mammals by the administration of compounds of the general formula (I) wherein A is O41 or NR42 R43 wherein R41 is hydrogen or a pharmaceutically acceptable inorganic or organic cation, or CORA wherein RA is alkyl and aryl; R42 and R43 are hydrogen, C1-C4-alkyl, cyclopropyl, cyclopentyl or cyclohexyl; or R42 is benzyl or phenethyl, optionally mono- or disubstituted by methyl, iso-propyl methoxy, fluoro, chloro, bromo, dimethylamino, trifluoromethyl or nitro and R43 is hydrogen; or R42 and R43 form a 5- or 6-membered ring; or R42 is CORB wherein RB is alkyl or aryl, —CH2N(CH3)2 or —CH2CH2COOH or CORB is a 2-acyloxymethylbenzoyl group wherein RC is methyl, ethyl, phenyl or benzyl; R42 is COORD wherein RD is C1-C4-alkyl, phenyl or benzyl; or R42 is —CH2OCO-tert.-butyl or R42 is CONRFRG wherein RF and RG are C1-C4-alkyl; or R42 is CXNHRE wherein X is O or S and RE is C1-C4-alkyl, C2-C4-alkyl functionalized with an tertiary amino group, or phenyl, optionally functionalised with a p-chloro group; or R42 is CH2NRHRI wherein RH and RI are C1-C4-alkyl and RH and RI form a morpholine ring and R43 is hydrogen, C1-C2-alkyl or cyclopropyl; R is hydrogen, C1-C4-alkyl or allyl; with the proviso that R is not hydrogen when A is OR41; R′ is hydrogen, methyl, methoxy, fluoro, chloro, bromo, cyano, nitro, azido, trifluoromethyl, or OCHxFy, wherein x=0-2, y=1-3 with the proviso that x+y=3; and that R′ is not hydrogen when R is methyl and A is OR41; R″ is hydrogen, fluoro or chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro; R5 is hydrogen, C1-C3-alkyl; methoxy, ethoxy, thio-C1-C3-alkyl fluoro, chloro, bromo, trifluoromethyl, nitro, amino, dimethylamino or OCHxFy, or OCH2CHxFy wherein x=0-2, y=1-3 with the proviso that x+y=3 and that R5 is not fluoro or amino when A is OR41; and that R5 is hydrogen only when A is NR42 R43 and R′ is trifluoromethyl; R6 is hydrogen; or R5 and R6 taken together are methylenedioxy, or any tautomer, optical isomer or racemate thereof. The invention also comprises novel compounds, therapeutic compositions and processes for the preparation of the compounds of formula I.

公开(公告)号：US07311479B2

公开(公告)日：2007-12-25

申请号：US11164760

申请日：2005-12-05

申请人： Johnny Bruhn ,  Mattias Puide ,  Mattias Svensson ,  Anders Björk ,  Jimmy Karlsson ,  Mikael Grönqvist

发明人： Johnny Bruhn ,  Mattias Puide ,  Mattias Svensson ,  Anders Björk ,  Jimmy Karlsson ,  Mikael Grönqvist

IPC分类号： B23B51/06

CPC分类号： B21C23/147 ,  B22F3/20 ,  B22F5/10 ,  B22F2005/001 ,  B23B51/06 ,  B23B2222/28 ,  B23B2250/12 ,  B23B2251/046 ,  B23P15/32 ,  Y10T407/14 ,  Y10T408/455 ,  Y10T408/9097

摘要： The present invention relates to a tool as well as a blank for manufacturing of the tool. The tool is made of solid cemented carbide and includes a shank for mounting in a rotatable spindle and chip flutes. Lines of intersection between the chip flutes and clearance surfaces form cutting edges at a cutting end of the tool. The flush channels extend through the entire tool in order to transfer flushing medium to the cutting end of the tool. The flush channels have varying pitch.

摘要翻译： 本发明涉及一种工具以及用于制造该工具的坯料。 该工具由固体硬质合金制成，包括用于安装在可旋转主轴和芯片槽纹中的柄。 芯片槽纹和间隙表面之间的交叉线在工具的切割端处形成切割边缘。 冲洗通道延伸穿过整个工具，以便将冲洗介质传送到工具的切割端。 冲洗通道具有不同的间距。

公开(公告)号：US06593343B2

公开(公告)日：2003-07-15

申请号：US10131176

申请日：2002-04-25

申请人： Anders Björk ,  Stig Jönsson ,  Tomas Fex ,  Gunnar Hedlund

发明人： Anders Björk ,  Stig Jönsson ,  Tomas Fex ,  Gunnar Hedlund

IPC分类号： A61K314704

CPC分类号： C07D215/56

摘要： Compounds of formula (I) and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.

摘要翻译： 式（I）化合物及其互变异构体对于治疗患有由自身免疫和病理性炎症引起的疾病的哺乳动物是有效的。

公开(公告)号：US06221858B1

公开(公告)日：2001-04-24

申请号：US09180292

申请日：1998-11-05

申请人： Anders Björk

发明人： Anders Björk

IPC分类号： C07D40104

CPC分类号： A61K31/506 ,  A61K31/496

摘要： Use of a compound of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R1 is either halogen or hydrogen and R2 is halogen; X is CH2, O or S; R3 and R4 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3; A is selected from the pyrimidyl- or pyridyl-groups (a), (b) or (c) wherein R5, R6 and R7 are as defined in the description; for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse or for treatment thereof.

摘要翻译： 式（I）化合物及其药学上可接受的酸加成盐的用途，其中R 1为卤素或氢，R 2为卤素; X是CH 2，O或S; R3和R4相同或不同，选自氢或低级烷基; n为2或3; A选自嘧啶基或吡啶基（a），（b）或（c），其中R 5，R 6和R 7如说明书中所定义; 用于制造用于缓解或预防由于滥用药物或物质或其治疗而成瘾引起的戒断综合征的药物。

公开(公告)号：US08434424B2

公开(公告)日：2013-05-07

申请号：US10593156

申请日：2005-03-17

申请人： Anders Björk ,  Gunnar Pettersson

发明人： Anders Björk ,  Gunnar Pettersson

IPC分类号： A01J3/00 ,  A01J5/00

CPC分类号： A01K1/12

摘要： A method for milking animals in a milking station (9) including a milking machine (14) for milking said animals, and a first feeding device (21) for feeding said animals intermittently or continuously with feed, is disclosed, the method comprising the steps of allowing a milking animal to enter the milking station (9); feeding the milking animal in the milking station intermittently or continuously with feed by means of the first feeding device (21); and milking the milking animal in the milking station (9) by means of the milking machine (14). According to the present invention, the feeding of the milking animal is terminated at a non-final stage of the milking in order to secure that the milking animal has terminated to consume the feed when the milking is finished.

摘要翻译： 公开了一种挤奶站（9）中的动物的挤压方法，该挤奶站（9）包括用于挤压所述动物的挤奶机（14），以及用于以进料间歇或连续地供给所述动物的第一进料装置（21），所述方法包括步骤 允许挤奶动物进入挤奶站（9）; 通过第一进料装置（21）间歇地或连续地用进料供给挤奶站中的挤奶动物; 以及通过挤奶机（14）将挤奶站（9）中的挤奶动物挤奶。 根据本发明，挤奶动物的喂养在挤奶的非最后阶段终止，以确保挤奶动物已经终止以在挤奶结束时消耗饲料。

公开(公告)号：US08314124B2

公开(公告)日：2012-11-20

申请号：US12405413

申请日：2009-03-17

申请人： Karl Jansson ,  Tomas Fristedt ,  Hans Wännman ,  Anders Björk

发明人： Karl Jansson ,  Tomas Fristedt ,  Hans Wännman ,  Anders Björk

IPC分类号： A61K9/28 ,  A61K31/4704 ,  C07D215/22

CPC分类号： A61K31/4704 ,  A61K31/4706 ,  C07D215/56

摘要： A stable solid pharmaceutical composition consisting essentially of an effective amount of a crystalline salt of formula (II) together with an alkaline-reacting component maintaining the pH preferably above 8, or a salt with a divalent metal cation; and at least one pharmaceutical excipient; said salt of formula (II) being essentially stable during storage at room temperature for a period of at least 3 years. A process for stabilizing the salt of formula (II). A crystalline salt of formula (II) and a process for preparing said salt.

摘要翻译： 一种稳定的固体药物组合物，其基本上由有效量的式（II）的结晶盐与保持pH优选高于8的碱反应组分或与二价金属阳离子形成的盐组成; 和至少一种药物赋形剂; 所述式（II）的盐在室温下储存至少3年的时间基本上是稳定的。 稳定式（II）的盐的方法。 式（II）的结晶盐和制备所述盐的方法。