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1.发明申请公开(公告)号：US20110034458A1
公开(公告)日：2011-02-10
申请号：US12906729
申请日：2010-10-18
申请人： Thomas RUECKLE , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
发明人： Thomas RUECKLE , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
IPC分类号： A61K31/5377 , C07D471/04 , C07D491/048 , A61K31/519 , A61K31/4985 , A61K31/4355 , A61K31/437 , A61P35/00 , A61P29/00 , A61P9/00 , A61P25/28 , A61P13/12 , A61P37/08 , A61P11/06 , A61P7/02 , A61P15/00 , A61P37/06 , A61P43/00 , A61P31/12 , A61P31/04
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡啶亚甲基唑烷酮衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集， 癌症，移植，移植排斥或肺部损伤。
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公开(公告)号：US07842696B2
公开(公告)日：2010-11-30
申请号：US12144604
申请日：2008-06-23
申请人： Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
发明人： Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
IPC分类号： A61K31/4965 , C07D295/00
CPC分类号： C07D333/18 , C07D207/416 , C07D211/62 , C07D231/12 , C07D231/14 , C07D261/08 , C07D295/192 , C07D307/68
摘要： The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US20090239848A1
公开(公告)日：2009-09-24
申请号：US12408367
申请日：2009-03-20
申请人： Kumar Sundaresan , Sandeep N. Raikar , Srinivasa Raju Sammeta , Ganesh Prabhu , Hosahalli S. Subramanya , Alexander Bischoff
发明人： Kumar Sundaresan , Sandeep N. Raikar , Srinivasa Raju Sammeta , Ganesh Prabhu , Hosahalli S. Subramanya , Alexander Bischoff
IPC分类号： A61K31/551 , C07D241/04 , A61K31/495 , C07D401/02 , A61K31/496 , C07D413/02 , A61K31/5377 , C07D243/08 , A61P3/04
CPC分类号： C07D295/108 , C07D213/74 , C07D231/40 , C07D263/54 , C07D271/06 , C07D271/107 , C07D277/44 , C07D295/185 , C07D295/192 , C07D295/26 , C07D333/20
摘要： The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
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公开(公告)号：US08129376B2
公开(公告)日：2012-03-06
申请号：US12408486
申请日：2009-03-20
申请人： Kumar Sundaresan , P. Bala Koteswara Rao , Bharathiraja Ainan , Hariharasubramanian Ayyamperumal , Girish A R , Srinivas Tatiparthy , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
发明人： Kumar Sundaresan , P. Bala Koteswara Rao , Bharathiraja Ainan , Hariharasubramanian Ayyamperumal , Girish A R , Srinivas Tatiparthy , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
IPC分类号： A61K31/5375 , A61K31/445 , C07D413/02 , C07D211/00
CPC分类号： C07D211/46 , C07D211/58 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌啶衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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5.发明授权公开(公告)号：US08058289B2
公开(公告)日：2011-11-15
申请号：US12906729
申请日：2010-10-18
申请人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
发明人： Thomas Rueckle , Anna Quattropani , Vincent Pomel , Jerome Dorbais , David Covini , Alexander Bischoff
IPC分类号： A61K31/4355 , C07D471/04 , A61P29/00 , A61P9/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P27/14 , A61P37/08 , A61P37/06 , A61P1/18 , A61P1/16 , A61P7/02 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译： 本发明涉及式（I）的吡啶亚甲基唑烷酮衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集， 癌症，移植，移植排斥或肺部损伤。
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公开(公告)号：US07897595B2
公开(公告)日：2011-03-01
申请号：US11752683
申请日：2007-05-23
IPC分类号： A61P3/00 , A61K31/55 , C07D487/04
CPC分类号： C07D471/04 , C07D491/147 , C07D495/14
摘要： The present invention relates to pyridoazepine derivatives that act as 5-HT ligands, e.g., 5-HT2 C. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为5-HT配体例如5-HT 2C的吡啶并吖庚因衍生物。本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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7.发明申请公开(公告)号：US20090221583A1
公开(公告)日：2009-09-03
申请号：US12144604
申请日：2008-06-23
申请人： Alexander BISCHOFF , Hosahalli SUBRAMANYA , Kumar SUNDARESAN , Srinivasa Raju SAMMETA , Anil Kumar VAKA
发明人： Alexander BISCHOFF , Hosahalli SUBRAMANYA , Kumar SUNDARESAN , Srinivasa Raju SAMMETA , Anil Kumar VAKA
IPC分类号： A61K31/5377 , C07D241/04 , C07D401/12 , C07D401/06 , A61P3/04 , A61P3/10 , C07D413/12 , A61K31/495 , A61K31/496
CPC分类号： C07D333/18 , C07D207/416 , C07D211/62 , C07D231/12 , C07D231/14 , C07D261/08 , C07D295/192 , C07D307/68
摘要： The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US20070281918A1
公开(公告)日：2007-12-06
申请号：US11752683
申请日：2007-05-23
申请人： Gian-Luca Araldi , Alexander Bischoff , Nhut Diep
发明人： Gian-Luca Araldi , Alexander Bischoff , Nhut Diep
IPC分类号： A61K31/55 , C07D487/02
CPC分类号： C07D471/04 , C07D491/147 , C07D495/14
摘要： The present invention relates to pyridoazepine derivatives that act as 5-HT ligands, e.g., 5-HT2C ligands. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为5-HT配体的吡啶并吖庚因衍生物，例如5-HT 2 C配体。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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9.发明申请公开(公告)号：US20120004213A1
公开(公告)日：2012-01-05
申请号：US13233555
申请日：2011-09-15
申请人： Kumar SUNDARESAN , Sandeep N. RAIKAR , Srinivasa Raju SAMMETA , Ganesh PRABHU , Hosahalli SUBRAMANYA , Alexander BISCHOFF
发明人： Kumar SUNDARESAN , Sandeep N. RAIKAR , Srinivasa Raju SAMMETA , Ganesh PRABHU , Hosahalli SUBRAMANYA , Alexander BISCHOFF
IPC分类号： A61K31/495 , C07D295/26 , C07D401/12 , C07D413/12 , A61P3/04 , C07D243/08 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D295/192 , C07D417/12
CPC分类号： C07D295/108 , C07D213/74 , C07D231/40 , C07D263/54 , C07D271/06 , C07D271/107 , C07D277/44 , C07D295/185 , C07D295/192 , C07D295/26 , C07D333/20
摘要： The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US08039463B2
公开(公告)日：2011-10-18
申请号：US12408367
申请日：2009-03-20
申请人： Kumar Sundaresan , Sandeep N. Raikar , Srinivasa Raju Sammeta , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
发明人： Kumar Sundaresan , Sandeep N. Raikar , Srinivasa Raju Sammeta , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
IPC分类号： A61K31/551 , A61K31/495 , A61K31/496 , C07D295/192 , C07D213/75 , C07D231/40 , C07D261/14 , C07D263/58 , C07D271/106 , C07D271/10 , C07D277/46 , C07D333/24
CPC分类号： C07D295/108 , C07D213/74 , C07D231/40 , C07D263/54 , C07D271/06 , C07D271/107 , C07D277/44 , C07D295/185 , C07D295/192 , C07D295/26 , C07D333/20
摘要： The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
摘要翻译： 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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