知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.014 秒)

    Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical uses thereof
    3.
    发明授权
    Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical uses thereof 失效

    公开(公告)号：US4402975A

    公开(公告)日：1983-09-06

    申请号：US284562

    申请日：1981-07-17

    申请人： Toru Takeshita ,  Kenji Hoshina ,  Akira Ohtsu ,  Tatsuyuki Naruchi

    发明人： Toru Takeshita ,  Kenji Hoshina ,  Akira Ohtsu ,  Tatsuyuki Naruchi

    IPC分类号： A61K31/135 ,  A61K31/195 ,  A61K31/24 ,  C07D295/18 ,  C07C101/34

    CPC分类号： C07C229/34 ,  A61K31/135 ,  C07C225/18 ,  C07C233/51 ,  C07C2101/14 ,  Y10S514/927 ,  Y10S514/928

    摘要： A compound represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group or an alkoxycarbonyl group; X.sup.1 represents an alkylene group having 3 to 6 carbon atoms, a 1,4-cyclohexylene group, or a 1,4-phenylene group, the alkylene group may be substituted by an alkyl group having 1 to 6 carbon atoms, and the 1,4-phenylene group may be substituted by 1 or 2 substituents selected from halogen atoms and alkoxy groups having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom or a hydroxyl group and R.sup.3 represents hydrogen atom, or R.sup.2 and R.sup.3 together may form an oxo group (.dbd.O), and when X.sup.1 is other than the 1,4-phenylene group, R.sup.2 represents a hydrogen atom and R.sup.3 represents a bond between the carbon atoms to which R.sup.3 is bonded and that carbon atom of X.sup.1 which is adjacent to said carbon atom; X.sup.2 represents an alkylene group having 1 to 5 carbon atoms which may be substituted by an alkyl group having 1 to 6 carbon atoms or an amino group; and R.sup.4 represents the group --COOR.sup.5, --CH.sub.2 OR.sup.6 or --CONR.sup.7 R.sup.8 in which R.sup.5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R.sup.6 represents a hydrogen atom or an acyl group having 1 to 6 carbon atoms, and R.sup.7 and R are identical or different and represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or taken together may form a 5- or 6-membered ring; or an acid addition salts of said compound wherein R.sup.1 represents a hydrogen atom or X.sup.2 represents an alkylene group having an amino group, or salts of said compound wherein R.sup.5 represents a hydrogen atom.The compounds represented by the above formula or their pharmaceutically acceptable salts are useful as anti-ulcer agents.The present invention also provides a process for producing the compounds or their pharmaceutically acceptable salts, which comprises acylating a protected derivative at the amino group of a corresponding acid halide with a corresponding substituted benzene in the presence of a Lewis acid; or reducing a corresponding compound in the presence of an inert solvent under conditions which induce reduction of the carbonyl group of said corresponding compound without substantially reducing the phenylene group of said corresponding compound; or dehydrating a corresponding compound.

    Image forming apparatus
    5.
    发明授权
    Image forming apparatus 失效
    图像形成装置

    公开(公告)号：US06839154B1

    公开(公告)日：2005-01-04

    申请号：US09497230

    申请日：2000-02-03

    申请人： Akira Ohtsu

    发明人： Akira Ohtsu

    IPC分类号： G03B27/72 ,  G06K9/32 ,  G06K9/36 ,  G06T1/00 ,  H04N1/04 ,  H04N1/32 ,  H04N1/387 ,  H04N1/393 ,  H04N1/46

    CPC分类号： H04N1/3935 ,  H04N1/00795 ,  H04N1/00816

    摘要： A system CPU checks whether a copying mode is selected. If the copying mode is selected, the system CPU calculates “read area=periphery of original 2−mm×100÷magnification.” If the copying mode is not selected, the system CPU checks whether a resolution conversion is effective or not. If the resolution conversion is not effective, the system CPU calculates “read area=periphery of original−2 mm×100÷magnification.” If the resolution conversion is effective, the system CPU calculates “read area=periphery of original−2 mm.” The system CPU instructs the scanner CPU to start scanning with the calculated read area.

    摘要翻译： 系统CPU检查是否选择复印模式。 如果选择了复印模式，则系统CPU计算“读取区域=原始2-mmx100 /放大倍数的周边”。 如果未选择复印模式，系统CPU会检查分辨率转换是否有效。 如果分辨率转换无效，则系统CPU计算“读取区域=原始-2mmx100 /放大倍率的周边”。 如果分辨率转换有效，则系统CPU计算“读取区域=原始外围2mm”。 系统CPU指示扫描仪CPU以计算的读取区域开始扫描。

    Thiaprostaglandin E.sub.1 derivatives, process for production thereof, and pharmaceutical use thereof
    6.
    发明授权
    Thiaprostaglandin E.sub.1 derivatives, process for production thereof, and pharmaceutical use thereof 失效
    Thiaprostaglandin E1衍生物，其制备方法及其药物用途

    公开(公告)号：US4466980A

    公开(公告)日：1984-08-21

    申请号：US316902

    申请日：1981-10-30

    申请人： Toshio Tanaka ,  Takeshi Toru ,  Takeo Oba ,  Noriaki Okamura ,  Kenzo Watanabe ,  Kiyoshi Bannai ,  Atsuo Hazato ,  Seizi Kurozumi ,  Fukuyoshi Kamimoto ,  Akira Ohtsu

    发明人： Toshio Tanaka ,  Takeshi Toru ,  Takeo Oba ,  Noriaki Okamura ,  Kenzo Watanabe ,  Kiyoshi Bannai ,  Atsuo Hazato ,  Seizi Kurozumi ,  Fukuyoshi Kamimoto ,  Akira Ohtsu

    IPC分类号： C07C405/00 ,  C07D309/12 ,  C07C177/00 ,  A61K31/557

    CPC分类号： C07C405/0033 ,  C07D309/12

    摘要： A novel compound selected from the group consisting of 7-(or 6- or 4-)thiaprostaglandin E.sub.1 derivatives of the formula (I). ##STR1## wherein A represents --CH.sub.2 -- or ##STR2## in which n is 0, 1 or 2, provided that only one A cut of three is ##STR3## R.sup.1 -R.sup.7 and G are as defined in the specification, the 15-epimers of said thiaprostaglandin E.sub.1 derivatives, the enatiomers of said thiaprostaglandin E.sub.1 derivatives or their 15-epimers, and mixtures of these compounds.A 7-thiaprostaglandin E.sub.1 derivative and/or its optical isomer may be prepared by reacting a 2-organo-2-cyclopentenone (II) with an organic copper-lithium compound (III) to effect conjugation reaction. A 6-thiaprostaglandin E.sub.1 derivative and/or its optical isomer may be prepared by subjecting an .alpha.,.beta.-unsaturated ketone (IV) and a thiol (V) to the Michael addition reaction. And, 4-thiaprostaglandin derivative and/or its optical isomer may also be prepared by the Michael addition reaction from a 2-allyl substituted cyclopentanone (VI) and a thiol (VIII).Some compounds ((I)-1) amongst the compounds of the formula (I) and/or their optical isomer are useful for controlling vascular actions such as angina pectoris, vasodilation etc.

    摘要翻译： 选自式（I）的7-（或6-或4-）赖氨酸前列腺素E1衍生物的新化合物。 （I）其中A表示-CH 2 - 或，其中n为0,1或2，条件是三个只有一个A切割是R 1 -R 7，G如说明书中所定义， 所述thiaprostaglandin E1衍生物的15-差向异构体，所述thiaprostaglandin E1衍生物或它们的15-差向异构体的对映体，以及这些化合物的混合物。 7-硫代前列腺素E1衍生物和/或其旋光异构体可以通过2-有机-2-环戊烯酮（II）与有机铜 - 锂化合物（III）反应来制备共轭反应。 6-硫代前列腺素E1衍生物和/或其旋光异构体可以通过使α，β-不饱和酮（IV）和硫醇（V）进行迈克尔加成反应来制备。 并且，也可以通过从2-烯丙基取代的环戊酮（VI）和硫醇（VIII）的迈克尔加成反应制备4-硫代前列腺素衍生物和/或其旋光异构体。 式（I）化合物和/或其旋光异构体中的一些化合物（（I）-1）可用于控制血管作用，例如心绞痛，血管舒张等。

    Image-scanning apparatus with a shading correction function
    9.
    发明授权
    Image-scanning apparatus with a shading correction function 失效
    具有阴影校正功能的图像扫描装置

    公开(公告)号：US5970181A

    公开(公告)日：1999-10-19

    申请号：US919261

    申请日：1997-08-28

    申请人： Akira Ohtsu

    发明人： Akira Ohtsu

    IPC分类号： H04N1/10 ,  H04N1/04 ,  H04N1/107 ,  H04N1/401 ,  H04N1/407 ,  H04N1/40

    CPC分类号： H04N1/4076

    摘要： An image-scanning apparatus for scanning an original in an image-reading area to output image data, includes, a platen on which the original is placed, a reference plate which has a reference color, and a scanning device for optically scanning the reference plate and the original placed on the platen to provide a first optical image and a second optical image. The image-scanning apparatus also has a receiving device for receiving the first optical image and the second optical image so as to output electrical signals, a setting device for setting a correcting amount on the basis of the electrical signals, a correcting device for correcting the scattering of the electrical signals to output the image data, a calculating device for calculating a pre-running length corresponding to a predetermined speed, the scanning device is accelerated in a pre-running portion corresponding to the pre-running length so that the scanning device reaches the predetermined speed, a determining device for determining that the reference plate is sufficiently included in the pre-running portion, a control system for controlling the scanning device and the setting device corresponding to the detecting operation of the determining device so that the scanning device performs the scanning operation efficiently.

    摘要翻译： 一种用于扫描图像读取区域中的原稿以输出图像数据的图像扫描装置包括：放置原稿的压板，具有基准颜色的参考板;以及用于光学扫描参考板的扫描装置 并且原稿放置在压板上以提供第一光学图像和第二光学图像。 图像扫描装置还具有用于接收第一光学图像和第二光学图像以便输出电信号的接收装置，用于基于电信号设置校正量的设置装置，用于校正 电信号的散射以输出图像数据;计算装置，用于计算与预定速度对应的预运行长度;扫描装置在对应于预运行长度的预运行部分中被加速，使得扫描装置 达到预定速度，用于确定参考板充分包括在预运行部分中的确定装置，用于根据确定装置的检测操作控制扫描装置和设置装置的控制系统，使得扫描装置 高效执行扫描操作。