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公开(公告)号：US20120316250A1
公开(公告)日：2012-12-13
申请号：US13581022
申请日：2011-02-25
IPC分类号： A61K47/32
CPC分类号： A61J3/077 , A61K9/4816 , A61K9/4891
摘要： This invention provides a hard capsule that has excellent stability even when filled with a solvent for dissolving poorly soluble drugs, and that also achieves reduction in disintegration time, thereby ensuring excellent solubility.Specifically, the hard capsule of the present invention has a film comprising: (A) a polymer or copolymer obtained by polymerizing or copolymerizing, in the presence of polyvinyl alcohol and/or a derivative thereof, at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms; and (B) native gellan gum.
摘要翻译： 本发明提供一种即使填充溶解难溶性药物的溶剂也具有优异的稳定性的硬胶囊，并且还实现崩解时间的降低，从而确保优异的溶解性。 具体地说，本发明的硬胶囊具有：（A）在聚乙烯醇和/或其衍生物的存在下聚合或共聚至少一种由式（ 1）：H 2 C = C（R 1）-COOR 2（1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基; 和（B）天然绞兰胶。
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公开(公告)号：US20110280937A1
公开(公告)日：2011-11-17
申请号：US13138255
申请日：2010-02-12
CPC分类号： A61K9/4816 , A61K9/4891
摘要： The object of the invention is to provide a hard capsule that is excellent in stability even when filled with a solvent for dissolving a poorly soluble pharmaceutical active ingredient, and that has excellent mechanical strength in a low-humidity environment. The invention provides a hard capsule having a film containing (A) a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1), wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or C1-C4 alkyl, in the presence of polyvinyl alcohol and/or a derivative thereof; and (B) at least one compound selected from the group consisting of (B-1) polyhydric alcohols, (B-2) esters of polyhydric alcohols and C1--C5 carboxylic acids, and (B-3) esters of polyvalent carboxylic acids and C1-C5 alcohols. The capsule of the present invention has excellent mechanical strength, while maintaining low moisture content, and thus exhibits excellent physical stability even when filled with a poorly soluble drug-dissolving solvent.
摘要翻译： 本发明的目的是提供即使在溶解难溶性药物活性成分的溶剂中也具有优异的稳定性的硬胶囊，并且在低湿度环境下具有优异的机械强度。 本发明提供了一种含有（A）通过聚合或共聚由式（1）表示的至少一种可聚合乙烯基单体得到的聚合物或共聚物的膜的硬胶囊：H2C = C（R1）-COOR2（1），其中R1表示 氢或甲基，R2表示氢或C1-C4烷基，在聚乙烯醇和/或其衍生物的存在下; 和（B）选自（B-1）多元醇，（B-2）多元醇和C 1 -C 5羧酸酯的至少一种化合物和（B-3）多元羧酸酯 和C 1 -C 5醇。 本发明的胶囊具有优异的机械强度，同时保持低含水量，并且因此即使填充有难溶性的药物溶解溶剂也显示出优异的物理稳定性。
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公开(公告)号：US20120157580A1
公开(公告)日：2012-06-21
申请号：US13392252
申请日：2010-08-31
IPC分类号： C09D101/28
CPC分类号： C09D151/003 , A23P20/105 , A23V2002/00 , A61K9/284 , A61K9/5026 , C08F261/04 , C08L1/26 , C08L1/28 , C08L1/284 , C09D101/26 , C09D101/28 , C09D101/284 , C09D131/00 , C09D133/02 , C08L2666/26 , A23V2200/22 , C08L33/02 , C08L29/04
摘要： A main object of the present invention is to provide a coating composition capable of maintaining an excellent moisture-proof property of coating compositions mainly comprising a polyvinyl alcohol polymer, as well as increasing the coating process speed and improving the productivity. The object is achieved by a coating composition comprising a polymer or copolymer (A) obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer in the presence of polyvinyl alcohol and/or a derivative thereof, and a cellulose-based polymer (B).
摘要翻译： 本发明的主要目的是提供一种能够保持主要包含聚乙烯醇聚合物的涂料组合物具有良好防湿性的涂料组合物，以及提高涂布速度和提高生产率。 该目的通过包含通过在聚乙烯醇和/或其衍生物和纤维素类聚合物（B）的存在下聚合或共聚至少一种可聚合乙烯基单体获得的聚合物或共聚物（A）的涂料组合物来实现。
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公开(公告)号：US08900628B2
公开(公告)日：2014-12-02
申请号：US13581022
申请日：2011-02-25
CPC分类号： A61J3/077 , A61K9/4816 , A61K9/4891
摘要： This invention provides a hard capsule that has excellent stability even when filled with a solvent for dissolving poorly soluble drugs, and that also achieves reduction in disintegration time, thereby ensuring excellent solubility.Specifically, the hard capsule of the present invention has a film comprising: (A) a polymer or copolymer obtained by polymerizing or copolymerizing, in the presence of polyvinyl alcohol and/or a derivative thereof, at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms; and (B) native gellan gum.
摘要翻译： 本发明提供一种即使填充溶解难溶性药物的溶剂也具有优异的稳定性的硬胶囊，并且还实现崩解时间的降低，从而确保优异的溶解性。 具体地说，本发明的硬胶囊具有：（A）在聚乙烯醇和/或其衍生物的存在下聚合或共聚至少一种由式（ 1）：H 2 C = C（R 1）-COOR 2（1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基; 和（B）天然绞兰胶。
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公开(公告)号：US20120022169A1
公开(公告)日：2012-01-26
申请号：US13258703
申请日：2010-04-02
申请人： Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino , Yoshinobu Fukumori , Yusuke Hayashi
发明人： Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino , Yoshinobu Fukumori , Yusuke Hayashi
CPC分类号： A61K9/4866 , A61K9/4816
摘要： The present invention provides a hard capsule that exhibits excellent stability even when filled with a solvent for dissolving a poorly soluble drug, and that achieves improved moldability and drying rate. As such a hard capsule, the present invention provides a hard capsule having a film containing (A) a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms, in the presence of polyvinyl alcohol and/or a derivative thereof, and (B) at least one water-soluble polymer selected from the group consisting of cellulose polymers, dextrin, and polyvinylpyrrolidone.
摘要翻译： 本发明提供即使在溶解难溶性药物的溶剂的情况下也显示出优异的稳定性的硬胶囊，并且能够提高成型性和干燥率。 作为这样的硬胶囊，本发明提供一种具有含有（A）通过使至少一种由式（1）表示的可聚合乙烯基单体聚合或共聚得到的聚合物或共聚物的膜的硬胶囊：H 2C≡C（R 1）-COOR 2 （1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基，在聚乙烯醇和/或其衍生物的存在下，和（B）至少一种选自以下的水溶性聚合物： 由纤维素聚合物，糊精和聚乙烯吡咯烷酮组成的组。
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