发明申请
- 专利标题: HARD CAPSULE
- 专利标题(中): 硬胶囊
-
申请号: US13138255申请日: 2010-02-12
-
公开(公告)号: US20110280937A1公开(公告)日: 2011-11-17
- 发明人: Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino
- 申请人: Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino
- 申请人地址: JP Osaka-shi
- 专利权人: Nisshin Kasei Co., Ltd.
- 当前专利权人: Nisshin Kasei Co., Ltd.
- 当前专利权人地址: JP Osaka-shi
- 优先权: JP2009-031370 20090213
- 国际申请: PCT/JP2010/052091 WO 20100212
- 主分类号: A61K9/48
- IPC分类号: A61K9/48 ; B05D3/00 ; B05D5/00 ; A61K47/32
摘要:
The object of the invention is to provide a hard capsule that is excellent in stability even when filled with a solvent for dissolving a poorly soluble pharmaceutical active ingredient, and that has excellent mechanical strength in a low-humidity environment. The invention provides a hard capsule having a film containing (A) a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1), wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or C1-C4 alkyl, in the presence of polyvinyl alcohol and/or a derivative thereof; and (B) at least one compound selected from the group consisting of (B-1) polyhydric alcohols, (B-2) esters of polyhydric alcohols and C1--C5 carboxylic acids, and (B-3) esters of polyvalent carboxylic acids and C1-C5 alcohols. The capsule of the present invention has excellent mechanical strength, while maintaining low moisture content, and thus exhibits excellent physical stability even when filled with a poorly soluble drug-dissolving solvent.
信息查询