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公开(公告)号：US12110500B2
公开(公告)日：2024-10-08
申请号：US17993667
申请日：2022-11-23
IPC分类号： C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
CPC分类号： C12N5/0606 , A61K39/001 , C12N5/0696 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00
摘要： Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US12098412B2
公开(公告)日：2024-09-24
申请号：US17717678
申请日：2022-04-11
发明人： Chien-Hsun Huang , Li-Wen Hsu , Jong-Shian Liou , I-Ching Chen , Sung-Yuan Hsieh , Chien-Chi Chen
CPC分类号： C12P7/52 , A61P1/04 , A61P43/00 , C12P2201/00 , C12P2203/00
摘要： Disclosed herein is an isolated strain of Roseburia hominis HGM001, which is deposited at Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH under an accession number DSM 34119. A method for producing butyric acid using the isolated strain of Roseburia hominis HGM001, a fermented culture produced by the method, and a method for alleviating an inflammatory disorder using the fermented culture are also disclosed.
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公开(公告)号：US12084479B2
公开(公告)日：2024-09-10
申请号：US16932372
申请日：2020-07-17
申请人： Academia Sinica
发明人： Chiaho Shih , Heng-Li Chen , Pei-Yi Su
CPC分类号： C07K14/005 , A01N37/46 , A01N63/50 , A61P31/04 , C07K7/08 , A61K38/00 , C12N2730/10122 , C12N2730/10133
摘要： An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.
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公开(公告)号：US12071397B2
公开(公告)日：2024-08-27
申请号：US17232729
申请日：2021-04-16
申请人： EVOLOGIE LLC
IPC分类号： C07C279/14 , A61K9/107 , A61K31/194 , A61K31/198 , A61K31/223 , A61K31/60 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/32
CPC分类号： C07C279/14 , A61K9/107 , A61K31/194 , A61K31/198 , A61K31/223 , A61K31/60 , A61K47/14 , A61K47/06 , A61K47/10 , A61K47/32 , A61K31/198 , A61K2300/00 , A61K31/194 , A61K2300/00 , A61K31/60 , A61K2300/00 , A61K31/223 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions and methods useful for the treatment of dermatological disorders, and in particular acne vulgaris and skin pigmentation disorders. Pharmaceutical compositions comprising one or more arginine, salicylic acid and/or azelaic acid that are useful for the treatment of dermatological diseases and the symptoms and underlying causes of such dermatological diseases are also disclosed.
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公开(公告)号：US12068059B2
公开(公告)日：2024-08-20
申请号：US16481061
申请日：2018-01-25
发明人： Vikram Khurana , Chee Yeun Chung , Susan Lindquist , Bonnie A. Berger , Ernest Fraenkel , Jian Peng
CPC分类号： G16B5/00 , C12Q1/025 , G01N33/5058 , G16B25/00 , G16B30/10 , G01N2500/10
摘要： Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.
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公开(公告)号：US12060588B2
公开(公告)日：2024-08-13
申请号：US17858758
申请日：2022-07-06
发明人： Rudolf Jaenisch , X. Shawn Liu , Hao Wu
IPC分类号： C12N9/22 , A61K35/30 , A61K35/33 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , C12N9/10 , C12N15/11 , C12N15/86 , C12N15/90
CPC分类号： C12N9/22 , A61K35/30 , A61K35/33 , C12N9/1007 , C12N15/11 , C12N15/86 , C12N15/907 , C12Y201/01037 , C12N2310/20 , C12N2740/15031 , C12N2800/80
摘要： The invention relates to methods of modifying DNA methylation by contacting a cell with a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences.
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公开(公告)号：US12031155B2
公开(公告)日：2024-07-09
申请号：US17993680
申请日：2022-11-23
IPC分类号： C12N5/0735 , A61K39/00 , C12N5/074 , C12N15/86 , C12N15/90
CPC分类号： C12N5/0606 , A61K39/001 , C12N5/0696 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2501/50 , C12N2501/599 , C12N2501/998 , C12N2510/00
摘要： Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic.
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公开(公告)号：US12018185B2
公开(公告)日：2024-06-25
申请号：US16910733
申请日：2020-06-24
IPC分类号： C09J175/04 , C09J177/00
CPC分类号： C09J175/04 , C09J177/00
摘要： Disclosed herein are improved adhesive compositions for bonding textiles and methods of producing the same.
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公开(公告)号：US12009663B2
公开(公告)日：2024-06-11
申请号：US17771358
申请日：2020-08-05
申请人： Zhejiang University
发明人： Zheng Xu , Yingjie Tang , Zheren Zhang
摘要： The present disclosure discloses an offshore wind farm low-frequency alternating-current uncontrolled rectification electric power transmission system, comprising an onshore converter station and an offshore alternating-current system. The offshore alternating-current system comprises wind turbine generators, alternating-current submarine cables, a confluence bus, and offshore booster stations; the onshore converter station comprises a wind field side alternating-current bus, an alternating-current system side alternating-current bus, an alternating-current filter, an energy dissipation device, a rectifier, and a converter; the rectifier is composed of a three-phase six-pulse uncontrolled rectifier bridge, and the converter may be an MMC or an LCC; the rated frequency of the offshore alternating-current system is selected to be close to 10 Hz.
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10.发明授权公开(公告)号：US11903742B2
公开(公告)日：2024-02-20
申请号：US17291357
申请日：2020-10-20
申请人： Aarca Research Inc.
IPC分类号： G06T7/11 , G06V10/25 , G06V10/44 , G06V40/16 , A61B5/0205 , A61B5/026 , A61B5/145 , A61B5/1455 , A61B5/00 , A61B5/01 , A61B5/02 , G06T7/00
CPC分类号： A61B5/7275 , A61B5/015 , A61B5/02007 , A61B5/02028 , A61B5/02055 , A61B5/0261 , A61B5/14546 , A61B5/14552 , A61B5/489 , A61B5/7257 , A61B5/7267 , G06T7/0012 , G06T7/11 , G06V10/25 , G06V10/443 , G06V40/171 , G06T2207/10016 , G06T2207/10048 , G06T2207/20056 , G06T2207/30104 , G06T2207/30201 , G06V2201/03
摘要： System and method for measuring dyslipidemia condition of a subject using thermal imaging is disclosed. The disclosed system and method includes thermal sensors for capturing thermal images and/or videos of a body part; and a processing engine to detect a predefined region of the body part in each frame of the captured images and/or videos. The processing engine segments one or more portions from the predefined region in each frame of the captured images and/or videos to identify a ROI comprising arteries in the segmented portions. Based on the identified region of interest, the engine extracts pixel values, representing biosignals, from each frame of the captured images and/or videos to determine parameters associated with a rate of atherosclerotic, levels of lipids and lipoproteins, and hemodynamic factors of the subject. Further a risk score for the dyslipidemia condition based on the determined parameters using computational models is measured.
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